Two-photon characterisation of long-Stokes-shift dye ATTO 490LS for single-laser multicolour imaging [0.03%]
用于单激光多色成像的长斯托克斯位移染料ATTO 490LS的双光子特性研究
King Yee Cheung,Yue Wu,Shu Ying Lee et al.
King Yee Cheung et al.
Long-Stokes-shift fluorophores enable high sensitivity and multiplexed imaging with single-wavelength excitation. Under single-photon illumination ATTO 490LS exhibits a 165-nm Stokes shift, but its two-photon properties remain uncharacteris...
Histone H3 Post-Translational Modification Changes are Linked to Manganese and Copper Exposure in Saccharomyces cerevisiae [0.03%]
端粒酵母中组蛋白H3的翻译后修饰变化与锰和铜暴露有关
William Villasi,Rania Frederic,Sidra Qureshi et al.
William Villasi et al.
Prolonged exposures to heavy metals are risk factors for chronic diseases, such as Amyotrophic Lateral Sclerosis and Frontotemporal dementia (ALS/FTD). ALS/FTD comprises a fatal neurodegenerative disease continuum and is linked to disruptio...
Exploring non-autonomous protein homeostasis driven by glutamatergic neurons [0.03%]
探索由谷氨酸能神经元驱动的非自主蛋白质稳态机制
Adam J Hruby,Aeowynn J Coakley,Evan Dittus et al.
Adam J Hruby et al.
Neuronal overexpression of xbp-1 s , a regulator of the endoplasmic reticulum unfolded protein response (UPR ER ), induces non-autonomous UPR ER activation in distal tissues of Caenorhabditis elegans . Specific neuronal subtypes, including ...
C. elegans mlt-11 activity is necessary in seam cells for molting and larval development [0.03%]
mlt-11在C. elegans seam细胞中的活性对于蜕皮和幼虫发育是必不可少的
James Matthew Ragle,Jordan D Ward
James Matthew Ragle
C. elegans gene mlt-11 is a Kunitz family putative protease inhibitor required for proper cuticle formation and molting. Using tissue-specific RNA interference we tested in which tissues mlt-11 activity was critical for molting and developm...
Generation of a functional fluorescently-tagged PFN-3 profilin transgene in Caenorhabditis elegans [0.03%]
用于斑马鱼的荧光标记PFN-3profilin功能基因的构建
Michael Kimmich,David Pruyne
Michael Kimmich
Profilin is a small actin-monomer binding protein that inhibits pointed-end elongation and spontaneous nucleation, but promotes formin-mediated assembly of actin onto barbed-ends. In Caenorhabditis elegans , the profilin PFN-3 , in conjunct...
The barley disease resistance protein AvrPphB Response 1 exhibits nucleocytoplasmic localization [0.03%]
大麦抗病蛋白AvrPphB Response 1具有核质兼备定位性质
Matthew Helm,Ariana Myers,Rachel Kelly et al.
Matthew Helm et al.
Plant immunity is partly mediated by intracellular nucleotide-binding leucine-rich repeat (NLR) proteins that detect pathogen effector activity, with NLR function often linked to subcellular localization. We previously showed the barley NLR...
Quantitative image analysis reveals no sexual dimorphism in the cellular dynamics of Drosophila heart tube formation [0.03%]
定量图像分析揭示了果蝇心管形成过程中不存在性别二态性细胞动力学现象
Rafael Perez-Vicente,Negar Balaghi,Rodrigo Fernandez-Gonzalez
Rafael Perez-Vicente
Congenital heart defects affect females and males differently. Several congenital heart defects arise during the formation of the heart tube, suggesting that heart tube morphogenesis may differ between females and males. We investigated if ...
Razan A Fakieh,Ranjana Kishore,Meera V Sundaram et al.
Razan A Fakieh et al.
MIG-15 is the sole Caenorhabditis elegans member of the GCK-IV subfamily of Ste20 kinases. In mammals and in vitro , MIG-15-like kinases can function as effectors of the small GTPase Rap2. To test this model in vivo , we compared phenotypes...
Kelci Grahmann,Chance Cecchine,Madison Rosales et al.
Kelci Grahmann et al.
Bacteriophage KNG13, a siphovirus, was isolated in San Antonio, Texas, USA, using Arthrobacter globiformis B-2979. KNG13 has a genome length of 15,768-bp and is assigned to actinobacteriophage cluster FE based on gene content. ...
The histone gene family in Drosophila simulans carries consistent species-specific nucleotide polymorphisms distinct from that of Drosophila melanogaster [0.03%]
果蝇物种Drosophila simulans中的组蛋白基因家族携带有与Drosophila melanogaster不同的特有核苷酸多态性
Sierra Falcone,Annalise Weber,Salaam Awad et al.
Sierra Falcone et al.
Drosophila melanogaster is a powerful model system to study histone gene regulation. However, D. melanogaster histone coding sequences are nearly identical, constraining use of this model in elucidating the regulation of individual members ...