The human GABA A receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits [0.03%]
与人类癫痫有关的GABAA受体α4亚基变异(Ile114Asn)会损害其与β3和δ亚基一起在膜上的表现
Draegan A Watson,Cecilia M Borghese,Kristina Jülich et al.
Draegan A Watson et al.
GABA A receptors mediate fast inhibitory neurotransmission in the brain, and variants in their subunits are linked to neurological disorders like epilepsy. For many identified variants, it remains to be determined whether the variant is ...
Estimating thermal death time curves in Drosophila tripunctata using infrared activity monitors [0.03%]
采用红外活动监测仪估算三点蚊Drosophila tripunctata的热致死时间曲线
Aaron R Yilmaz,Logan R Kolaske,Ryan A Martin et al.
Aaron R Yilmaz et al.
Assessing heat failure across different test temperatures allows for the estimation of heat tolerance and thermal sensitivity under the thermal death time (TDT) model of damage accumulation. One challenge is phenotyping sufficient numbers o...
Revival of Mucin-Degrading Human-Derived Fecal Microbial Consortia After Cryopreservation [0.03%]
人源粪便微生物菌群降解粘蛋白能力的复苏能力评估试验
Ava N Tafreshi,Teanna Samuel,Gilberto E Flores et al.
Ava N Tafreshi et al.
Human gut microbial communities capable of degrading mucin are taxonomically unique and have a range of physiologically relevant metabolic outputs. To determine the feasibility of reviving mucin-degrading fecal microbial communities after c...
Nociceptor activity is required for a robust immune response in Drosophila larvae [0.03%]
痛觉感受器活动是果蝇幼虫免疫反应的必要条件
Lydia J Borjon,W Daniel Tracey
Lydia J Borjon
The nervous system and the immune system play a shared role in defending Drosophila larvae against injury and infection. Potentially harmful stimuli are detected by nociceptive neurons that trigger escape behaviors, while wounds and foreign...
Searching for vertically transmitted endosymbionts in over 4,000 wild strains of three self-fertilizing Caenorhabditis species [0.03%]
从三个自体受精的线虫物种的四千多份野外分离株中寻找垂直传播的内共生菌
Lance M O&#x;Connor,Anupama Singh,Robert J Luallen et al.
Lance M O&#x;Connor et al.
Vertically transmitted endosymbionts are microbes that live inside host cells and are transmitted between parent and offspring. Free-living nematodes interact with a wide variety of microbes but no vertically transmitted microbes have been ...
Functional Annotation of FD Cluster Phage Bouclier that Infects Arthrobacter globiformis [0.03%]
一个能够感染黏质赛伯氏菌的噬菌体Bouclier的功能注释及其基因簇FD_cluster的研究
Matias Espinosa,Hannah Atchley,Kaden K Bambach et al.
Matias Espinosa et al.
Phage Bouclier has a 19,912bp genome with 29 protein coding genes and infects Arthrobacter globiformis B-2979. Transmission electron microscopy visualizes Bouclier as a podovirus. This is confirmed by identification of genes encoding struct...
Two novel paralogous C. elegans proteins bind to LON-1 but do not have a major role in body size regulation [0.03%]
两个新颖的线虫同源蛋白与LON-1结合但不参与主要体型调控作用
Dillon M Gardner,Byron Williams,Zhiyu Liu et al.
Dillon M Gardner et al.
The BMP signaling pathway regulates body size and mesoderm fate specification in C. elegans . The secreted protein LON-1 both regulates and is regulated by BMP signaling. The mechanism through which LON-1 functions is unclear. In this study...
julius seizure acts within teashirt -expressing neurons to protect Drosophila melanogaster from bang-sensitivity [0.03%]
julius通过调控teashirt表达神经元来减少果蝇晕厥现象
Derek M Dean,Lillian E Codd,Mira Eras et al.
Derek M Dean et al.
Loss of function in the Drosophila melanogaster gene julius seizure ( jus ) causes the fly to have a seizure-like condition known as bang-sensitivity. Here, we characterize the expression patterns of two different jus reporters, a jus -GAL4...
Method of Removal of Aquatic Pond Weed Variably Impacts Presence of Potentially Toxic Cyanobacteria [0.03%]
不同除草方法对有毒蓝藻生长的影响不同
Sarah D Princiotta,Emily Ostergaard,Elizabeth Carroll
Sarah D Princiotta
Lakes often exist in two alternative stable states: clear waters dominated by submerged aquatic vegetation and turbid states with an abundance of phytoplankton. Management decisions must balance the value of primary producers with recreatio...
Mei-P26 bidirectionally modulates feeding behavior, locomotion and glucose levels via insulin-neurons in Drosophila [0.03%]
果蝇Mei-P26通过胰岛素神经双向调节进食行为、运动和血糖水平
Tolulope Olaolorun,Elena Pak,Alexander Murashov
Tolulope Olaolorun
Mei-P26 is associated with cell-fate regulation in Drosophila melanogaster . In prior work, offspring of Western diet-fed fathers exhibited hyperphagia accompanied by increased brain Mei-P26. Because feeding is regulated by insulin/ILP sign...