Assessment of Lectin Staining Biomarkers using a Murine Model of GNE Myopathy [0.03%]
评估GNE肌病小鼠模型中的凝集素染色生物标志物
Olivia Parker,Jordyn Woods,Max Rothkopf et al.
Olivia Parker et al.
GNE myopathy (GNEM) is a rare myopathy caused by mutations in the UDP-GlcNAc epimerase/ManNAc-6 kinase (GNE) gene, which reduce sialic acid (SA) biosynthesis and impair muscle through unclear mechanisms. As development of SA-restoring GNEM ...
Inhibition of acn-1 , an ACE ortholog, reduces intestinal GST-4 expression in Caenorhabditis elegans [0.03%]
抑制acn-1（一种ACE同源物）可降低秀丽隐杆线虫肠道中GST-4的表达
Josiah King,Kristopher Schmidt
Josiah King
We investigated the role of acn-1 , the C. elegans ortholog of human ACE and ACE2, on the expression of GST-4 , an antioxidant molecule produced in response to oxidative stress. acn-1 RNAi exposure significantly reduced GST-4 reporter expre...
Artificial selection for flower size in Brassica rapa reveals moderate heritability and many correlated traits [0.03%]
对芸薹芸苔花大小的人工选择显示了中等的遗传力和许多相关性状
Megan L Van Etten
Megan L Van Etten
With the ultimate goal of better understanding the impact of flower size on pollinator attraction, mating patterns, and plant fitness, four generations of artificial selection were performed on flower diameter in Brassica rapa . Selection p...
Three isoforms of Brugia malayi daf-16 activate a reporter gene in cultured HepG2 cells [0.03%]
布鲁姬马来肺丝虫三种daf-16同工型可激活肝癌细胞株HepG2中的报告基因
Cameron E Zehr,Alexius Folk,Katherine Stanford et al.
Cameron E Zehr et al.
We hypothesize that infective stage molting in the parasitic nematode Brugia malayi is regulated by an ortholog of the Caenorhabditis elegansdaf-16 gene, similar to the role of daf-16 in dauer formation and recovery. We confirmed the gene s...
Louison Bois Naegelin,Valérie Courgnaud,Dominique Helmlinger et al.
Louison Bois Naegelin et al.
Deltaviruses were recently discovered across a broad range of metazoan species. Their genome encodes a single protein and thus requires host factors for replication, which are likely evolutionarily conserved given their broad host range. He...
Intragenic suppressors of the C. elegans clk-2(qm37) mutation [0.03%]
C. elegansclk-2(qm37)突变的抑癌基因抑制剂
Marin Pascal,Laurent Cappadocia,Siegfried Hekimi et al.
Marin Pascal et al.
The C. elegans gene clk-2 , which encodes the orthologue of yeast Tel2p and human TELO2, is implicated in development, lifespan, and telomere length regulation, among other functions. The thermosensitive allele clk-2 ( qm37 ) (C772Y) is let...
Comparison of chemical treatments to ablate the lateral line system in two freshwater fishes, bumblebee goby Brachygobius doriae and silver hatchetfish Gasteropelecus sp [0.03%]
两种淡水鱼电水母ганоцит lesbische lesbische lesbienne salopes wannonce salopes salopes beurette beurette beurette wannonce wannonce salopes salopes salopes beurette beurette beurette wannonce wannonce salopes salopes salopes beurette beurette beurette wannonce wannonce salopes salopes salopes beurette beure
Hridey Kapoor,Jeremy Levin,Anais Azevedo et al.
Hridey Kapoor et al.
Chemically ablating the lateral line system is a useful tool to temporarily and non-invasively inactivate this sensory system, so that the role of this sensory system can be revealed in behaviors relying on flow sensing. Here we determined ...
A bacterial food source for effective laboratory cultivation of the freshwater nematode Plectus sambesii [0.03%]
一种细菌食物来源可有效培养淡水线虫Plectus sambesii
Luke T Geiger,Joke Evenblij,Oliver Hobert
Luke T Geiger
The successful establishment of a new satellite animal model system depends in no small part on the ability to effectively cultivate such animals at scale in the laboratory. We describe here the discovery of a bacterial food source, Pseudom...
Spontaneous and heritable change in iridescent properties of bacterium Tenacibaculum discolor str. IMLK18 [0.03%]
发光菌Tenacibaculum discolor 菌株IMLK18 发色性质的自发和遗传改变
Hooi Lynn Kee
Hooi Lynn Kee
Iridescence is a structural color phenomenon where varying-colored hues arise from the interaction of light with physical surfaces, rather than from chemical pigments. Iridescence was thought to be unique to specific organisms such as butte...
Acinetobacter baumannii does not affect Candida albicans Susceptibility to Fluconazole in vitro [0.03%]
鲍曼不动杆菌不会影响白色念珠菌对氟康唑的敏感性
Autumn Perley,Allie Conner,Melody Neely et al.
Autumn Perley et al.
Candida albicans is the most common human fungal pathogen and is difficult to treat due to the scarcity of and increasing resistance to fungicidal drugs. C. albicans is commonly isolated with bacterial pathogens such as Pseudomonas aerugino...