Rebeccah J Katzenberger,Barry Ganetzky,David A Wassarman
Rebeccah J Katzenberger
Traumatic brain injury (TBI) is a major public health concern, affecting millions of people worldwide each year. Older individuals who experience a TBI face a higher risk of cognitive decline, disability, and mortality compared with younger...
Specific auxin and medium combinations alter Saccharomyces cerevisiae growth [0.03%]
特定的生长素与培养基组合可改变酿酒酵母的生长状况
Neta Nnabuenyi,Morgan A Sands,Nicole J Camlin
Neta Nnabuenyi
Auxin-inducible degradation is an increasingly popular protein-targeting reverse genetics approach. Use of this method has revolutionized the types of questions cell and molecular biologists can answer, however, a growing number of studies ...
Conditional Changes in Brood Size and Speed of Development After Long-term Laboratory Culturing of C. elegans Wild-type Strains [0.03%]
模式生物秀丽隐杆线虫野生型种群的长期实验室培养对其后代数量和发育速率的影响
Jocelyn M Mertz,Ashley Kim,Bruce Wightman
Jocelyn M Mertz
Prolonged culturing of laboratory animals allows for genetic changes to occur in a population, potentially leading to phenotypic variation in designated wild-type strains. We discovered that two of our laboratory's C. elegans wild-type stra...
Defining the necessity of the lipoic acid synthase lias-1 in Caenorhabditis elegans [0.03%]
线粒体辅助因子硫辛酸在秀丽杆线虫中的必要性分析及机理研究
Linnea B Parker,Philippa Murray,Peter A Kropp
Linnea B Parker
Lipoic acid is an essential cofactor for multiple enzymes involved in aerobic respiration, and disruption to any of the pathways contributing to lipoic acid synthesis result in severe respiratory dysfunction. Despite the importance of lipoi...
spook haploinsufficiency exacerbates aging-related motor impairments [0.03%]
SPOOK半剂量不足会加重与衰老相关的运动障碍
Veronica C Ciliberto,Maya Solis,Carolyne Chepkosgei et al.
Veronica C Ciliberto et al.
The global rise in aging populations heightens the risk of motor decline, reducing quality of life and increasing morbidities, yet aging-related motor impairments (AMI) remain poorly understood. Many steroid hormones synthesized by cytochro...
Genomic characterization of bla OXA-48 -carrying IncL plasmids in Enterobacterales in Vietnam [0.03%]
越南肠杆菌目生物体中携带bla OXA-48 的IncL质粒的基因组特征
Linh Dieu Tran,Duy Thai Pham,Nhu Duong Tran et al.
Linh Dieu Tran et al.
Carbapenem-hydrolyzing β-lactamase (carbapenemase) genes have been disseminated among bacteria worldwide; however, only a few instances of bacterial isolates harboring the carbapenemase gene bla OXA-48 have been reported in Vietnam. Here w...
Antibiotic Activity of Superior Class Traditional Chinese Medicine Herbs on Escherichia coli [0.03%]
名优中药对大肠杆菌的抗菌活性研究
Angela Li,Dominic Kassing,Annette Neuman et al.
Angela Li et al.
Escherichia coli has developed resistance to most available antibiotics, creating an urgent need for alternative antimicrobial agents. Traditional Chinese Medicine herbs have historically treated infectious diseases and may offer promising ...
Resveratrol protects male Drosophila melanogaster from heat stress-induced paralysis through a mechanism independent of heat shock response activation [0.03%]
白藜芦醇通过不激活热休克反应的机制保护雄性果蝇（Drosophila melanogaster）免受热应激引起的麻痹现象
Nichole Webb,Riley Bricker,Tyra Skalos et al.
Nichole Webb et al.
There is great interest in understanding the mechanism of action of antioxidant treatments and their cellular effects. Heat shock causes proteins to denature and lose their function. To mitigate this, cells utilize the heat shock response (...
Optimizing a C. elegans whole organism screen biased for chemicals that target the nematode clade specific receptor EAT-2 [0.03%]
优化模式生物秀丽隐杆线虫(Escherichia coli)全基因组筛选体系以偏向选择作用于作用于线虫特有受体EAT-2的化合物
Henry Atemnkeng Nvenankeng,Jim Goodchild,Philippa Harlow et al.
Henry Atemnkeng Nvenankeng et al.
Pesticides are important resources in the control of pests and pathogens of plants and animals. Unfortunately, there are concerns around their broad impacts on non-target organisms and the environment. In this study we optimize a platform b...
Musculoskeletal miRNA profiling after exposure to simulated space stressors in mice [0.03%]
模拟空间应力暴露的小鼠肌肉骨骼miRNA谱分析
Carly Orr,Emma Mackey,Azemat Jamshidi-Parsian et al.
Carly Orr et al.
Prolonged spaceflight exposes astronauts to chronic irradiation and microgravity, inducing oxidative stress through the production of reactive oxygen species (ROS). This study identified two microRNAs, Mir6236 and Mir6240, that were signifi...