The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains functional by metalation with cobalt [0.03%]
二价铁羧酸盐羟基酶COQ7被体内的锰金属化抑制，但通过钴金属化保持功能
Ying Wang,Siegfried Hekimi
Ying Wang
Coenzyme Q (CoQ; ubiquinone) is an obligate component of the mitochondrial electron transport chain. COQ7 is a mitochondrial hydroxylase that is required for CoQ biosynthesis. COQ7 belongs to di-iron carboxylate enzymes, a rare type of enzy...
Effect of DMSO on lifespan and physiology in C. elegans : Implications for use of DMSO as a solvent for compound delivery [0.03%]
DMSO对秀丽隐杆线虫寿命和生理学的影响及其作为化合物递送溶剂的使用含义
Abdelrahman AlOkda,Jeremy M Van Raamsdonk
Abdelrahman AlOkda
Dimethyl sulfoxide (DMSO) is a solvent that has been used for basic and medical research based on its ability to dissolve both polar and non-polar compounds. In order to use DMSO to deliver compounds that may impact longevity or neurodegene...
Oocyte CTR1 is not essential for cisplatin-induced oocyte death of primordial follicle [0.03%]
卵母细胞CTR1并非原始卵泡卵母细胞对顺铂诱导死亡所必需的因素
Seok-Yeong Yu,Yi Luan,Amirhossein Abazarikia et al.
Seok-Yeong Yu et al.
Accumulated evidence indicates that cisplatin, a platinum-based alkylating agent, causes preferential DNA damage to oocytes of primordial follicles (PFs) in the ovary, suggesting oocyte-favored accumulation of cisplatin. Copper transporter ...
Phylogenetic annotation of Caenorhabditis elegans heat shock protein 70 genes [0.03%]
芽囊原虫热休克蛋白70基因的系统发生学注释
Pirzada Hasnain,Gen Kaneko
Pirzada Hasnain
Annotation of the 70 kDa heat shock proteins (Hsp70s) has been chaotic especially in invertebrates. In this study, we validated an emerging nomenclature of Hsp70s, which can be potentially applied to all metazoan Hsp70s, by conducting a gen...
Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function [0.03%]
拟南芥DAP1蛋白中协调血红素铁的残基Y83对于细胞色素P450的功能至关重要
Shan Zhao,Adam L Hughes,Peter J Espenshade
Shan Zhao
Fission yeast Dap1 is a heme binding protein required for cytochromes P450 activity. Here, we tested whether Dap1 axial coordination of heme iron is required for its role in the function of the cytochrome P450 enzymes, Erg5 and Erg11. Two d...
Kinesin-5 and kinesin-14 are partially antagonistic in spindle assembly in the holocentric silkworm B. mori cells [0.03%]
Kinesin-5和Kinesin-14在全着丝点蚕巴氏斑细胞中有部分拮抗作用以完成纺锤体的组装过程
Inaara T Kassamaly,Gaetan Cornilleau,Ines A Drinnenberg et al.
Inaara T Kassamaly et al.
We previously showed that the silkworm holocentric spindles are square-shaped, compared to the canonical oval shape of human monocentric spindles (Vanpoperinghe et al. 2021). Further, while kinesin-5 depletion resulted in monopolar spindles...
Enteroendocrine cell expression of split-GAL4 drivers bearing regulatory sequences associated with panneuronally expressed genes in Drosophila melanogaster [0.03%]
果蝇全神经元表达基因的分裂GAL4启动子驱动器在肠内分泌细胞中的表达
Jessica M Holsopple,Kevin R Cook,Ellen M Popodi
Jessica M Holsopple
In Drosophila melanogaster , hormone-secreting enteroendocrine cells are important for communication from the midgut to other tissues. Many lexA, GAL4, and split-GAL4 drivers that direct gene expression in enteroendocrine cells also confer ...
Modelling the Caenorhabditis elegans gonad over developmental time using the Distal Tip Cell marker lag-2p::gfp [0.03%]
利用近端顶细胞标记lag-2p::gfp构建发育过程中Caenorhabditis elegans生殖腺的模型
Matt Crook,Tanya Carvajal,Payton Davis et al.
Matt Crook et al.
Development is a process that occurs over time, but defects are often scored at the end point of the process being studied. We are interested in understanding the molecular basis of gonad development in Caenorhabditis elegans and have used ...
Timing of High-glucose Diet in the C. elegans Lifecycle Impacts Fertility Phenotypes [0.03%]
秀丽隐杆线虫生命周期中高葡萄糖饮食的时间影响其生育表型
Amanda K Engstrom,Caroline D Davis,Jason L Erichsen et al.
Amanda K Engstrom et al.
Human metabolic diseases and high-sugar diets have been associated with infertility. Previous studies show that high-glucose diet also affects fertility in C. elegans, leading to decreased offspring production and delayed reproductive timin...
An endogenous mCherry-tagged COSA-1 as a crossover investigation tool in Caenorhabditis elegans [0.03%]
用于模式生物秀丽杆线虫中染色体交叉互换研究的COSA-1-mCherry内源性标记系
Chiemekam Samuel Ezechukwu,Arome Solomon Odiba,Guiyan Liao et al.
Chiemekam Samuel Ezechukwu et al.
The C. elegans cosa-1 gene encodes the crossover site-associated-1 (COSA-1) protein, a cyclin-related protein that functions in promoting crossovers (COs) during meiosis. Previous studies regarding CO dynamics in live C. elegans have mostly...