The BET inhibitor sensitivity is associated with the expression level of CDC25B in pancreatic cancer models [0.03%]
BET抑制剂的敏感性与胰腺癌模型中CDC25B表达量的关系研究
Aubrey L Miller,Patrick L Garcia,Rebecca B Vance et al.
Aubrey L Miller et al.
Aim: Cell division cycle 25B (CDC25B) belongs to the CDC25 family of phosphatases that regulate cell cycle progression. CDC25B also contributes to tumor initiation and progression, but no connection between CDC25B levels and drug sensitivit...
Emerging roles of small extracellular vesicles in metabolic reprogramming and drug resistance in cancers [0.03%]
小型细胞外囊泡在癌症代谢重编程序和耐药中的新兴作用
Jingcun Shi,Ying Shen,Jianjun Zhang
Jingcun Shi
Studies of carcinogenic metabolism have shown that cancer cells have significant metabolic adaptability and that their metabolic dynamics undergo extensive reprogramming, which is a fundamental feature of cancer. The Warburg effect describe...
Research progress on the role and mechanism of circular RNA in drug resistance of head and neck squamous cell carcinoma [0.03%]
圆rna在头颈部鳞癌药物耐药中的作用及机制研究进展
Hongli Zeng,Junshang Ge,Yi Meng et al.
Hongli Zeng et al.
Drug resistance in tumors constitutes a significant obstacle to tumor therapy. Head and neck squamous cell carcinoma (HNSCC) presents a major challenge due to its deep anatomical location, limited space, and complex structure. These factors...
Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro [0.03%]
体外筛选光敏剂与ATP结合盒式转运蛋白的相互作用
Shruti Vig,Payal Srivastava,Idrisa Rahman et al.
Shruti Vig et al.
Aim: ATP-binding cassette (ABC) transporters are proteins responsible for the efflux of drug molecules from cancer cells, reducing the efficacy of anti-cancer treatments. This study assesses the susceptibility of a panel of clinically used ...
Cancer-associated fibroblast cell surface markers as potential biomarkers or therapeutic targets in lung cancer [0.03%]
癌症相关成纤维细胞表面标志物作为肺癌生物标志物或治疗靶点的潜力研究
Samaneh Tokhanbigli,Mehra Haghi,Kamal Dua et al.
Samaneh Tokhanbigli et al.
Cancer-associated fibroblasts (CAFs) are the vital constituent of the tumor microenvironment, and in communication with other cells, they contribute to tumor progression and metastasis. Fibroblasts are the proposed origin of CAFs, which are...
Competing endogenous RNAs (ceRNAs) and drug resistance to cancer therapy [0.03%]
竞争性内源RNA（ceRNA）与癌症治疗耐药性
Kenneth K W To,Hang Zhang,William C Cho
Kenneth K W To
Competing endogenous RNAs (ceRNAs) are transcripts that possess highly similar microRNA response elements (MREs). microRNAs (miRNAs) are short, endogenous, single-stranded non-coding RNAs (ncRNAs) that can repress gene expression by binding...
Current applications of tumor local ablation (TLA) combined with immune checkpoint inhibitors in breast cancer treatment [0.03%]
肿瘤局部消融联合免疫检查点抑制剂治疗乳腺癌的当前应用
Lingpeng Tang,Dandan Wang,Ting Hu et al.
Lingpeng Tang et al.
Breast cancer is one of the most common cancers in women globally, posing significant challenges to treatment because of the diverse and complex pathological and molecular subtypes. The emergence of immune checkpoint inhibitors (ICIs) has r...
Intercellular transfer of multidrug resistance mediated by extracellular vesicles [0.03%]
细胞间多药耐药的转移由胞外囊泡介导
Anxiang Yang,Hui Sun,Xiaokun Wang
Anxiang Yang
Multidrug resistance (MDR) poses a formidable obstacle in cancer treatment, enabling cancer cells to evade the cytotoxic effects of chemotherapeutic drugs through various mechanisms. These mechanisms include intrinsic resistance, which is p...
Yulong Zhang,Yingming Peng,Bingqin Lin et al.
Yulong Zhang et al.
Head and neck cancer (HNC) is ranked as the sixth most common malignant tumor, and the overall survival rate with current treatment options remains concerning, primarily due to drug resistance that develops following antitumor therapy. Rece...
The uniqueness of ABCB5 as a full transporter ABCB5FL and a half-transporter-like ABCB5β [0.03%]
ABCB5作为完整转运体ABCB5FL和类似半转运体的ABCB5β的独特性
Louise Gerard,Jean-Pierre Gillet
Louise Gerard
The ABCB5 gene encodes several isoforms, including two transporters (i.e., ABCB5FL, ABCB5β) and several soluble proteins, such as ABCB5α which has been hypothesized to have a regulatory function. ABCB5FL is a full ABC transporter and is e...