A systematic review and network meta analysis of first-line immunotherapy for advanced urothelial carcinoma [0.03%]
一线免疫检查点抑制剂治疗晚期尿路上皮癌的系统评价和网状Meta分析
Yang Liu,Yuxuan Song,Jilin Wu et al.
Yang Liu et al.
Aim: To compare the efficacy and safety of first-line systemic therapies for advanced urothelial carcinoma (UC) and identify the relative benefit-risk profiles of available regimens. Methods: We conducted a systematic review and Bayesian ra...
Unveiling the role of UGT enzymes in chemoresistance: a path to enhanced cancer pharmacotherapy [0.03%]
UGT酶在化疗耐药中的作用及其在癌症药物治疗中的应用研究路径探讨
Gesine Kretzschmar,Youssif Budagaga,Lisa Groß et al.
Gesine Kretzschmar et al.
Aim: Chemotherapeutic resistance is a leading cause of cancer-related mortality worldwide. It has been suggested to be at least partly driven by the activity of uridine diphosphate glucuronosyltransferases (UGTs). However, this hypothesis i...
Fenretinide in cancer therapy and chemoprevention: past, present and future [0.03%]
癌症治疗和化学预防中的 fenretinide：过去、现在与未来
Paola Verachi,Federica Francescangeli,Rosanna Dattilo et al.
Paola Verachi et al.
Fenretinide [N-(4-hydroxyphenyl) retinamide, 4-HPR] is a synthetic retinoid known for decades for its antitumor activity and favorable toxicological profile. In vitro and in vivo studies have demonstrated that fenretinide has broad-spectrum...
TRAP1 ablation improves mitochondrial cristae and oxidative phosphorylation in pancreatic cancer stem cells [0.03%]
线粒体动态改变能改善胰腺癌干细胞的代谢和分化
Giulia Ambrosini,Elisa Dalla Pozza,Ilaria Cristanini et al.
Giulia Ambrosini et al.
Aim: Cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC) display high metabolic plasticity, supporting tumor aggressiveness and therapeutic resistance. Here, we investigated the role of the mitochondrial chaperone TRAP1 in r...
Deep spatial proteomics reveals a suppressive immune niche linked to immune evasion in renal cell carcinoma [0.03%]
深度空间蛋白质组学揭示肾细胞癌免疫逃逸相关的抑制性免疫微环境
Yujia Zhang,Yicheng Zhu,Zichang Liu et al.
Yujia Zhang et al.
Aim: Clear cell renal cell carcinoma (ccRCC) presents an "immune paradox" where high CD8+ T cell infiltration correlates with poor survival and limited response to immune checkpoint blockade (ICB). Simple cell density metrics fail to captur...
Lijun Li,Yanbin Zhao,Xinhong Shi et al.
Lijun Li et al.
Recently, programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have achieved major breakthroughs in oncology, with 32 drugs approved over the past decade. This advancement has established immunotherapy as the fifth major a...
Tumor heterogeneity as a driver of drug resistance and its implications for personalized therapy [0.03%]
肿瘤异质性驱动药物耐药及其对个性化治疗的启示
Erhan Da,Ronglan Zhu,Bin Xi et al.
Erhan Da et al.
Tumors are highly dynamic diseases characterized by significant heterogeneity. They consist of multiple cellular populations with distinct properties that respond differently to therapeutic pressure. This heterogeneity may arise from spatia...
Ultrasonic modulation of brain glymphatic transport: from observations to theranostic applications [0.03%]
超声波调节脑脊液循环：从现象到诊疗一体化应用
Wonseok Choi,Min-Hyeok Jang,Chulhong Kim et al.
Wonseok Choi et al.
The glymphatic system in the brain controls the cerebrospinal fluid (CSF) circulation and metabolic waste clearance, which is crucial for understanding the mechanisms and therapeutic opportunities of various brain pathologies. With the rapi...
Nanomaterial-based strategies overcome PD-1 related intrinsic immune resistance [0.03%]
基于纳米材料的策略克服PD-1相关的内在免疫抵抗作用
Yiyang Lin,Jianliang Shen
Yiyang Lin
Immune-checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) have substantially improved outcomes for patients with multiple cancer types; however, primary (intrinsic) resistance remains...
Novel N-chloroacetyl-2-pyrazoline analogs with 2-naphthyl and ferrocenyl groups: targeting histamine receptor H1 to overcome colorectal cancer drug resistance [0.03%]
新型N-氯乙酰-2-吡唑啉衍生物对组胺受体H1的作用及克服结直肠癌耐药性研究
Dileepkumar Veeragoni,Hindole Ghosh,Affan Ansari et al.
Dileepkumar Veeragoni et al.
Aim: This study investigates the anticancer activity of naphthalene- and ferrocene-based 2-pyrazolines against colorectal cancer (CRC) cell lines and assesses their potential to overcome chemotherapy resistance. Methods: Several 2-pyrazolin...