Integrative multi-omics analysis for identifying novel therapeutic targets and predicting immunotherapy efficacy in lung adenocarcinoma [0.03%]
整合多组学分析在肺癌新药靶发现及免疫治疗反应预测中的应用研究
Zilu Chen,Kun Mei,Foxing Tan et al.
Zilu Chen et al.
Aim: Lung adenocarcinoma (LUAD), the most prevalent subtype of non-small cell lung cancer (NSCLC), presents significant clinical challenges due to its high mortality and limited therapeutic options. The molecular heterogeneity and the devel...
Regulatory role of non-coding RNAs in 5-Fluorouracil resistance in gastrointestinal cancers [0.03%]
非编码RNA在消化道肿瘤氟尿嘧啶耐药中的调控作用
Heng Zhang,Hailin Tang,Wenling Tu et al.
Heng Zhang et al.
Gastrointestinal (GI) cancers are becoming a growing cause of morbidity and mortality globally, posing a significant risk to human life and health. The main treatment for this kind of cancer is chemotherapy based on 5-fluorouracil (5-FU). H...
Cancer-associated fibroblast-derived extracellular vesicles: regulators and therapeutic targets in the tumor microenvironment [0.03%]
癌相关成纤维细胞来源的外泌体：肿瘤微环境中的调控者和治疗靶点
Jindong Xie,Xinmei Lin,Xinpei Deng et al.
Jindong Xie et al.
Cancer-associated fibroblasts (CAFs) constitute a critical component of the tumor microenvironment (TME). CAFs can be reprogrammed by cancer cells, leading to the production of extracellular vesicles (EVs). These EVs serve as carriers for b...
Optimizing therapeutic approaches for HR+/HER2- advanced breast cancer: clinical perspectives on biomarkers and treatment strategies post-CDK4/6 inhibitor progression [0.03%]
HR阳性/HER2阴性晚期乳腺癌治疗进展后的临床生物标志物和治疗策略视角以优化治疗方法
Juan Miguel Cejalvo Andújar,Francisco Ayala de la Peña,Mireia Margeli Vila et al.
Juan Miguel Cejalvo Andújar et al.
This review offers an expert perspective on biomarkers, CDK4/6 inhibitor efficacy, and therapeutic approaches for managing hormone receptor-positive (HR+), human epidermal growth factor receptor-negative (HER2-) advanced breast cancer (ABC)...
The emerging role of GLP-1 receptor agonists in treating or preventing cancer [0.03%]
肠促胰素受体激动剂在癌症治疗或预防中的新兴作用
David J Benjamin,Daniel D Von Hoff
David J Benjamin
With the growing incidence of obesity-related malignancies, glucagon-like peptide-1 (GLP-1) receptor agonists represent an intriguing potential clinical avenue for cancer prevention and treatment. Population-based data suggest that individu...
Role of the TME in immune checkpoint blockade resistance of non-small cell lung cancer [0.03%]
肿瘤微环境在非小细胞肺癌免疫检查点抑制剂耐药中的作用
Yuening Dai,Xueqi Tian,Xuanting Ye et al.
Yuening Dai et al.
Primary and secondary resistance to immune checkpoint blockade (ICB) reduces its efficacy. The mechanisms underlying immunotherapy resistance are highly complex. In non-small cell lung cancer (NSCLC), these mechanisms are primarily associat...
CIRCUS: CIRCUlating tumour cells in soft tissue Sarcoma - a short report [0.03%]
循环肿瘤细胞在软组织肉瘤中的研究——短篇报告
Robin J Young,Joanna E Chowdry,Denis Cochonneau et al.
Robin J Young et al.
Aims: Circulating tumour cells (CTCs) can be detected in peripheral blood using their physical properties (increased size and less deformable than normal circulating blood cells) or using cell surface markers. The study of these CTCs should...
Ovarian tumor microenvironment contributes to tumor progression and chemoresistance [0.03%]
卵巢肿瘤微环境促进肿瘤进展和化学抗性
Adriana Ponton-Almodovar,Samuel Sanderson,Ramandeep Rattan et al.
Adriana Ponton-Almodovar et al.
Ovarian cancer is one of the deadliest gynecologic cancers affecting the female reproductive tract. This is largely attributed to frequent recurrence and development of resistance to the platinum-based drugs cisplatin and carboplatin. One o...
Yunan Nie,Kurt A Schalper,Anne Chiang
Yunan Nie
Small-cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with a poor prognosis. Although the addition of immunotherapy to chemotherapy has modestly improved outcomes, most patients rapidly develop resistance. Resistance to immuno...
Mitochondrial genome variability and metabolic alterations reveal new biomarkers of resistance in testicular germ cell tumors [0.03%]
线粒体基因组变异和代谢改变揭示了睾丸生殖细胞瘤耐药的新生物标志物
Pavlina Kabelikova,Danica Ivovic,Zuzana Sumbalova et al.
Pavlina Kabelikova et al.
Aim: Mutations in the mitochondrial (mt) genome contribute to metabolic dysfunction and their accumulation relates to disease progression and resistance development in cancer cells. This study explores the mutational status of the mt genome...