Identification of sequence-specific interactions of the CD44-intracellular domain with RUNX2 in the transcription of matrix metalloprotease-9 in human prostate cancer cells [0.03%]
人前列腺癌细胞中基质金属蛋白酶-9转录过程中CD44-胞内域与RUNX2的序列特异性相互作用的识别
Linda T Senbanjo,Hanan AlJohani,Mohammed AlQranei et al.
Linda T Senbanjo et al.
Aim: The Cluster of differentiation 44 (CD44) transmembrane protein is cleaved by γ-secretase, the inhibition of which blocks CD44 cleavage. This study aimed to determine the biological consequence of CD44 cleavage and i...
Quantitative analysis of taxane drug target engagement of microtubules in circulating tumor cells from metastatic castration resistant prostate cancer patients treated with CRXL301, a nanoparticle of docetaxel [0.03%]
接受CRXL301（一种多西他赛纳米粒）治疗的转移性去势抵抗性前列腺癌患者循环肿瘤细胞中紫杉类药物靶点结合的定量分析
Eiman Mukhtar,Daniel Worroll,Giuseppe Galletti et al.
Eiman Mukhtar et al.
Aim: We reviewed the radiographic response of three patients with metastatic castration-resistant prostate cancer treated with CRXL301, a docetaxel nanoparticle. For these three patients, we isolated and analyzed circulat...
MEK inhibition activates STAT signaling to increase breast cancer immunogenicity via MHC-I expression [0.03%]
MEK抑制通过MHC-I表达激活STAT信号以增加乳腺癌的免疫原性
Derek A Franklin,Jamaal L James,Margaret L Axelrod et al.
Derek A Franklin et al.
Aim: Immunotherapy and immune checkpoint inhibitors (ICI) have changed cancer care for many patients; however, breast cancers have exhibited minimal response to single agent ICI therapy. There is a significant need to ide...
Israa Salem,Nicole M Naranjo,Amrita Singh et al.
Israa Salem et al.
Cells are known to release different types of vesicles such as small extracellular vesicles (sEVs) and large extracellular vesicles (LEVs). sEVs and LEVs play important roles in intercellular communication, pre-metastatic niche formation, a...
Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy [0.03%]
肠道菌群：调控免疫和化学疗法疗效的新角色
Simone Anfossi,George A Calin
Simone Anfossi
Development of drug resistance represents the major cause of cancer therapy failure, determines disease progression and results in poor prognosis for cancer patients. Different mechanisms are responsible for drug resistance. Intrinsic genet...
Gene silencing of HIF-2α disrupts glioblastoma stem cell phenotype [0.03%]
干扰HIF-2α基因可破坏胶质母细胞瘤干细胞的表型
Leora M Nusblat,Shaili Tanna,Charles M Roth
Leora M Nusblat
Aim: Improved treatment strategies are desperately needed for eradicating cancer stem cells (CSCs), which drive malignancy and recurrence in glioblastoma multiforme. Hypoxic regions within the tumor microenvironment help ...
Effects of DNA topoisomerase IIα splice variants on acquired drug resistance [0.03%]
DNA拓扑异构酶IIα剪接变异体对获得性药物耐药的影响
Terry S Elton,Hatice Gulcin Ozer,Jack C Yalowich
Terry S Elton
DNA topoisomerase IIα (170 kDa, TOP2α/170) induces transient DNA double-strand breaks in proliferating cells to resolve DNA topological entanglements during chromosome condensation, replication, and segregation. Therefore, TOP2α/170 is a...
Enhanced Kat3A/Catenin transcription: a common mechanism of therapeutic resistance [0.03%]
增强的Kat3A/Catenin转录：耐药性的共同机制
Andrea Bild,Jia-Ling Teo,Michael Kahn
Andrea Bild
Cancers are heterogeneous at the cellular level. Cancer stem cells/tumor initiating cells (CSC/TIC) both initiate tumorigenesis and are responsible for therapeutic resistance and disease relapse. Elimination of CSC/TIC should therefore be a...
Reetobrata Basu,John J Kopchick
Reetobrata Basu
Pituitary derived and peripherally produced growth hormone (GH) is a crucial mediator of longitudinal growth, organ development, metabolic regulation with tissue specific, sex specific, and age-dependent effects. GH and its cognate receptor...
The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance [0.03%]
上皮间质转化和自噬在癌症药物耐药中的作用的重要性分析
Charlotte Hill,Yihua Wang
Charlotte Hill
Epithelial-mesenchymal transition (EMT) and autophagy are both known to play an important role in the development of cancer. Subsequently, these processes are now being utilised as targets for therapy. Cancer is globally one of the leading ...