Genomic stability at the coding regions of the multidrug transporter gene ABCB1: insights into the development of alternative drug resistance mechanisms in human leukemia cells [0.03%]
多药转运蛋白基因ABCB1编码区的基因组稳定性：对人类白血病细胞中替代药物抵抗机制发展的认识
Kevin G Chen,George E Duran,Mark J Mogul et al.
Kevin G Chen et al.
Aim: Despite considerable efforts to reverse clinical multidrug resistance (MDR), targeting the predominant multidrug transporter ABCB1/P-glycoprotein (P-gp) using small molecule inhibitors has been unsuccessful, possibly...
Robert C A M van Waardenburg,Eddy S Yang
Robert C A M van Waardenburg
Experimental models of endocrine responsive breast cancer: strengths, limitations, and use [0.03%]
内分泌反应性乳腺癌的实验模型：优势，限制及使用
Robert Clarke,Brandon C Jones,Catherine M Sevigny et al.
Robert Clarke et al.
Breast cancers characterized by expression of estrogen receptor-alpha; ESR1) represent approximately 70% of all new cases and comprise the largest molecular subtype of this disease. Despite this high prevalence, the number of adequate exper...
William H Gmeiner,Robert C A M van Waardenburg
William H Gmeiner
Advances in preclinical evaluation of experimental antibody-drug conjugates [0.03%]
实验抗体药物偶联物临床前评估的进展
Scott K Lyons,Dennis Plenker,Lloyd C Trotman
Scott K Lyons
The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the clinic. As the number of suc...
P53-regulated autophagy and its impact on drug resistance and cell fate [0.03%]
p53调控的自噬及其对药物抗性和细胞命运的影响
Daeun Shim,Lei Duan,Carl G Maki
Daeun Shim
Wild-type p53 is a stress-responsive transcription factor and a potent tumor suppressor. P53 inhibits the growth of incipient cancer cells by blocking their proliferation or inducing their death through apoptosis. Autophagy is a self-eating...
Epstein-Barr virus-associated post-transplant lymphoproliferative disorders: beyond chemotherapy treatment [0.03%]
移植后与EB病毒相关的淋巴增生性疾病：化疗之外的治疗策略
Sanam Shahid,Susan E Prockop
Sanam Shahid
Post-transplant lymphoproliferative disorder (PTLD) is a rare but life-threatening complication of both allogeneic solid organ (SOT) and hematopoietic cell transplantation (HCT). The histology of PTLD ranges from benign polyclonal lymphopro...
Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy [0.03%]
利用DNA修复通路提高放射治疗敏感性、克服耐受性和保护正常组织的功效
Jac A Nickoloff,Lynn Taylor,Neelam Sharma et al.
Jac A Nickoloff et al.
More than half of cancer patients are treated with radiotherapy, which kills tumor cells by directly and indirectly inducing DNA damage, including cytotoxic DNA double-strand breaks (DSBs). Tumor cells respond to these threats by activating...
Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review [0.03%]
替莫唑胺耐药在胶质母细胞瘤中的机制——全面综述
Neha Singh,Alexandra Miner,Lauren Hennis et al.
Neha Singh et al.
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an exceedingly low median overall survival of only 15 months. Current standard-of-care for GBM consists of gross total surgical resection followed by radi...
Cancer stem cells, epithelial-mesenchymal transition, ATP and their roles in drug resistance in cancer [0.03%]
癌症干细胞、上皮间质转化、ATP及它们在癌症耐药中的作用
Haiyun Zhang,Alexander Steed,Milo Co et al.
Haiyun Zhang et al.
The cancer stem cell (CSC) state and epithelial-mesenchymal transition (EMT) activation are tightly interconnected. Cancer cells that acquire the EMT/CSC phenotype are equipped with adaptive metabolic changes to maintain low reactive oxygen...