CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis [0.03%]
CF10/LV通过下调c-Myc/ABCB5轴克服结直肠癌细胞对5-氟尿嘧啶/亚叶酸钙的获得性耐药性
Charles Chidi Okechukwu,William H Gmeiner
Charles Chidi Okechukwu
Aim: Acquired resistance to 5-fluorouracil/leucovorin (5-FU/LV) frequently develops during treatment of metastatic colorectal (mCRC), but the causes are incompletely understood. We aim to: (i) identify the causes of 5-FU/LV resistance under...
IRE1α modulates M1 oncolytic virus sensitivity via ER stress regulation in bladder cancer [0.03%]
IRE1α通过调节内质网应激调控膀胱癌M1溶瘤病毒敏感性
Cheng Hu,Song Wei,Wenbo Zhu et al.
Cheng Hu et al.
Aim: Muscle-invasive bladder cancer (MIBC) remains lethal despite promising oncolytic virotherapy, hindered by tumor-intrinsic resistance. This study aimed to elucidate the molecular basis underlying differential sensitivity to the oncolyti...
MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance [0.03%]
甲状腺癌药耐受性中微核糖核酸介导的自噬作用调节机制研究
Dongye Huang,Qianwen Liu,Chang Liu et al.
Dongye Huang et al.
Thyroid cancer, particularly papillary thyroid cancer (PTC), represents the most prevalent endocrine malignancy. Despite advancements in therapeutic strategies, drug resistance significantly hampers clinical outcomes. Autophagy, an evolutio...
Super-enhancer inhibitors THZ2 and JQ1 reverse temozolomide resistance in glioblastoma by suppressing SE-driven SOX9 expression [0.03%]
表观遗传药物THZ2和JQ1通过抑制超级增强子驱动的SOX9表达逆转胶质母细胞瘤的替莫唑胺耐药性
Xinqi Teng,Yiming Wang,Qiang Qu et al.
Xinqi Teng et al.
Aim: Glioblastoma (GBM) is the most malignant grade of glioma, characterized by high recurrence, poor prognosis, and frequent chemoresistance. There is an urgent need for alternative treatment strategies. In this study, we evaluated the eff...
Modeling methods of different tumor organoids and their application in tumor drug resistance research [0.03%]
不同肿瘤类器官的建模方法及其在肿瘤耐药研究中的应用
Chengming Yang,Lushan Yang,Yuchen Feng et al.
Chengming Yang et al.
Tumor organoids were modeled in vitro to mimic in vivo culture conditions, allowing tumor-derived tissue cells or isolated and purified tumor stem cells to self-assemble into 3D preclinical models that are similar to tissues and organs in v...
Lactylation: a novel driver of drug resistance in the tumor microenvironment [0.03%]
乳酰化：肿瘤微环境中耐药的新驱动因素
Chunwei Li,Ziqiang Liu,Dezheng Kong et al.
Chunwei Li et al.
Lactylation, a novel lactate-derived lysine post-translational modification (PTM), has emerged as a critical epigenetic regulator driving drug resistance within the tumor microenvironment (TME). This review systematically delineates the enz...
PER2 expression and cellular localization play a critical role in tumor aggressiveness and drug resistance in an in vitro model of hepatocellular carcinoma [0.03%]
PER2的表达及细胞定位通过体外肝癌模型影响肿瘤侵袭性及药物耐受性
Mariarosaria Negri,Feliciana Amatrudo,Donatella Paola Provvisiero et al.
Mariarosaria Negri et al.
Aim: The current in vitro study investigated the role of Period 2 (PER2) in aggressiveness and the acquisition of drug resistance in hepatocellular carcinoma (HCC). Methods: Parental PLC/PRF/5 cells, along with everolimus-resistant (EveR) a...
Fibroblast growth factor receptor alterations and resistance mechanisms in the treatment of pediatric solid tumors [0.03%]
儿童实体瘤治疗中 fibroblast 生长因子受体改变及耐药机制
Ivan Li,Yuchen Huo,Ting Yang et al.
Ivan Li et al.
Aim: The fibroblast growth factor receptor (FGFR) family receptors regulate cell proliferation, survival, and migration and are linked to cancer drug resistance. FGFR gene family alterations have been found in multiple adult cancers, for wh...
Advances in the application of patient-derived xenograft models in acute leukemia resistance [0.03%]
急性白血病耐药患者来源异种移植模型的研究进展
Ronghao Qin,Yuxing Liang,Fuling Zhou
Ronghao Qin
Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are genetically heterogeneous malignancies of hematopoietic stem cells, characterized by complex mutations and a high risk of drug resistance and relapse. Patient-derived x...
FGFR1 overexpression promotes resistance to PI3K inhibitor alpelisib in luminal breast cancer cells through receptor tyrosine kinase signaling-mediated activation of the estrogen receptor [0.03%]
FGFR1过表达通过受体酪氨酸激酶信号介导的雌激素受体活化促进PI3K抑制剂阿培利塞在腔内乳腺癌细胞中的耐药性
Yujie Shi,Lexia Chen,Qiong Cheng et al.
Yujie Shi et al.
Aim: Resistance to PI3K inhibitor alpelisib is an emerging challenge in breast cancer treatment. FGFR1 is frequently amplified in breast cancer. We investigated FGFR1 overexpression-mediated alpelisib resistance and its mechanism. Methods: ...