Veronika Benson,Abbas Amini
Veronika Benson
Nanodiamonds represent an attractive potential carrier for anticancer drugs. The main advantages of nanodiamond particles with respect to medical applications are their high compatibility with non-cancerous cells, feasible surface decoratio...
Manipulation of the immune system by non-small cell lung cancer and possible therapeutic interference [0.03%]
非小细胞肺癌对免疫系统的调控及可能的治疗干预措施
Helmut H Popper
Helmut H Popper
Pulmonary carcinomas have developed mechanisms by which they escape the attack of immune cells. Immune checkpoint molecules programmed death 1 - programmed death ligand 1 (PD1-PDL1) and the cytotoxic T-lymphocyte antigen 4 system have gaine...
Gloria Ravegnini,Patrizia Hrelia,Sabrina Angelini
Gloria Ravegnini
Gastrointestinal stromal tumors (GISTs) are rare entities, which, however, represent the most common mesenchymal tumor of the gastrointestinal tract. The discovery of gain of function mutations on KIT and PDGFRA receptor genes led to a deep...
Meike Kaehler,Ingolf Cascorbi
Meike Kaehler
Cancer pharmacogenetics implies a complex combination of germline variants from the patient and somatic mutations in tumor cells. Somatic mutations meanwhile have become drugable targets or biomarkers, whereas germline mutations potentially...
Imaging of hypoxia in human glioblastoma with dynamic 18F-fluoromisonidazole PET [0.03%]
人脑胶质母细胞瘤动态18F-氟化错霉素PET低氧影像学研究
Redha-Alla Abdo,Frédéric Lamare,Philippe Fernandez et al.
Redha-Alla Abdo et al.
Aim: The purpose of this study was to locate the levels of hypoxia in glioblastoma PET images measured with 18F-fluoromisonidazole in human subjects. It is recognized that tumors with hypoxia are resistant to treatment by radiotherapy and c...
Influence of lysosomal sequestration on multidrug resistance in cancer cells [0.03%]
溶酶体隔离对癌细胞多药耐药性的影响
Reginald Halaby
Reginald Halaby
Chemotherapy remains a primary treatment modality for various malignancies. However, resistance to chemotherapeutic drugs is a major obstacle to curative cancer therapy. Lysosomes are acidic organelles that participate in cellular digestion...
Resistance to anti-tubulin agents: From vinca alkaloids to epothilones [0.03%]
从长春花生物碱到埃坡霉素：对抗抗微管药物的耐药性
Werner Krause
Werner Krause
This review describes the mechanism of action - inhibition of microtubules - and the most important mechanisms of resistance for vinca alkaloids, taxanes and epothilones. Resistance is a major problem in vinca and taxane chemotherapy and ar...
Dmitrii Shek,Scott A Read,Golo Ahlenstiel et al.
Dmitrii Shek et al.
Pharmacogenetics is the study of therapeutic and adverse responses to drugs based on an individual's genetic background. Monoclonal antibodies (mAbs) are a rapidly evolving field in cancer therapy, however a number of newly developed and hi...
Opportunities and challenges of implementing Pharmacogenomics in cancer drug development [0.03%]
癌症药物开发中实施肿瘤分子生物学的机遇与挑战
Paolo Tarantino,Dario Trapani,Stefania Morganti et al.
Paolo Tarantino et al.
Cancer drug development is a time and resources consuming process. Around 90% of drugs entering clinical trials fail due to lack of efficacy and/or safety issues, more often after conspicuous research and economic efforts. Part of the disca...
Bernhard Biersack
Bernhard Biersack
Alkylating agents represent an important class of anticancer drugs. The occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics. A detailed understanding of the mechanisms...