Distinct adaptive strategies to cisplatin, vinblastine and gemcitabine in a panel of chemoresistant bladder cancer cell lines [0.03%]
顺铂、长春花碱和吉西他滨抗性膀胱癌细胞系的适应策略
Monika Cuprych-Belter,Agnieszka Łupicka-Słowik,Artur Anisiewicz et al.
Monika Cuprych-Belter et al.
Aim: Urinary bladder cancer (UBC) often develops chemoresistance, reducing treatment effectiveness. This study aimed to investigate diverse molecular mechanisms underlying acquired resistance by establishing and characterizing a comprehensi...
ROS1 mutations promote an immunosuppressive tumor microenvironment via MYC to confer immune evasion in head and neck cancer [0.03%]
ROS1突变通过MYC促进免疫抑制性肿瘤微环境以使头颈癌逃避免疫攻击
Chao Fang,Qin Zhang,Rui Fang et al.
Chao Fang et al.
Aim: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; however, their efficacy in head and neck cancer (HNC) remains limited, with only a minority of patients achieving durable responses. Understanding the molecular mecha...
New advances in understanding the mechanisms and treatment challenges of ALK-targeted therapy resistance in lung cancer [0.03%]
ALK靶向治疗耐药机制及治疗挑战的最新研究进展
Mengle Long,Shixuan Peng,Qingyang Wen et al.
Mengle Long et al.
Despite the development of various effective anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs), therapeutic resistance remains a major challenge. Both on-target and off-target mechanisms have been identified as key contributo...
Effects of FAP+ cancer-associated fibroblasts on anti-PD-1 immunotherapy and CD4+ T cell polarization in gastric cancer [0.03%]
FAP+癌相关成纤维细胞对胃癌免疫治疗及CD4+T细胞极化的影响
Jing Wu,Peng-Fei Zhang,Yu Zeng et al.
Jing Wu et al.
Aim: The immune evasion mechanisms of gastric cancer are complex, involving various cellular dysfunctions within the tumor microenvironment. Recently, there has been growing interest in how cancer-associated fibroblasts (CAFs) contribute to...
Interactions between tumor microenvironment and resistance to transarterial and systemic treatments for HCC [0.03%]
肿瘤微环境与肝癌经动脉和系统治疗抵抗之间的相互作用
Maria Stella Franzè,Francesca Saffioti,Vasileios K Mavroeidis
Maria Stella Franzè
Hepatocellular carcinoma (HCC) is a malignant tumor originating from hepatocytes, often developing against a backdrop of chronic inflammation and liver fibrosis. The primary risk factor for HCC is cirrhosis, and early detection is crucial f...
Decoding breast cancer treatment resistance through genetic, epigenetic, and immune-regulatory mechanisms: from molecular insights to translational perspectives [0.03%]
通过遗传、表观遗传和免疫调节机制解读乳腺癌治疗耐药性：从分子见解到转化视角
Suryendu Saha,Samikshya Mahapatra,Sinjan Khanra et al.
Suryendu Saha et al.
Breast cancer continues to be the primary cause of cancer-related deaths among women globally, with increased rates of incidence and mortality, highlighting the critical need for effective treatment strategies. Recent developments have intr...
Integrated multi-omics profiling of immune microenvironment and drug resistance signatures for precision prognosis in prostate cancer [0.03%]
整合多组学对免疫微环境和药物耐药标志物的分析用于精准预测前列腺癌预后
Chao Li,Longxiang Wu,Bowen Zhong et al.
Chao Li et al.
Introduction: Prostate cancer (PCa) continues to be a significant cause of mortality among men, with treatment resistance often influenced by the complexity of the tumor microenvironment (TME). This study aims to develop an immune-centric p...
The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy [0.03%]
抗体药物偶联物在癌症和自身免疫治疗中的下一个前沿：挑战与机遇
Meijiang Zhou,Zhiwen Huang,Zijun Ma et al.
Meijiang Zhou et al.
Antibody-Drug Conjugates (ADCs) have achieved significant success in cancer therapy by combining the targeting specificity of monoclonal antibodies with cytotoxic payloads. However, the concomitant issue of drug resistance has become increa...
Corosolic acid increases the therapeutic effect of cisplatin on gastric cancer by regulating Gpx4-dependent ferroptosis [0.03%]
洛索前列素酸通过调节Gpx4依赖性铁死亡增强胃癌中顺铂的治疗效果
Liubing Lin,Jian Wang,Shun Sheng et al.
Liubing Lin et al.
Aim: Cisplatin serves as a primary chemotherapeutic agent in the treatment of gastric cancer (GC), but resistance to cisplatin-based chemotherapeutic regimens hampers its clinical application. Corosolic acid (CA), a natural triterpenoid, ex...
Antibody-drug conjugates in breast cancer: current resistance mechanisms and future combination strategies [0.03%]
抗体药物偶联物在乳腺癌中的当前耐药机制及未来联合策略
Ping Xing,Chenghui Yang,Hanwen Hu et al.
Ping Xing et al.
Antibody-drug conjugates (ADCs), inspired by Paul Ehrlich's "magic bullet" concept to target cancer cells with cytotoxic drugs while sparing healthy cells, represent a transformative approach in breast cancer therapy. From early agents (e.g...