Advancing CAR T-cell therapy for chronic lymphocytic leukemia: exploring resistance mechanisms and the innovative strategies to overcome them [0.03%]
慢性淋巴细胞性白血病的CAR-T细胞治疗进展：探究耐药机制及创新性解决方案
Azra Borogovac,Tanya Siddiqi
Azra Borogovac
Chimeric antigen receptor (CAR) T-cell therapy has ushered in substantial advancements in the management of various B-cell malignancies. However, its integration into chronic lymphocytic leukemia (CLL) treatment has been challenging, attrib...
Chemosensitizing effect of pentoxifylline in sensitive and multidrug-resistant non-small cell lung cancer cells [0.03%]
氨茶碱对敏感和多药耐药非小细胞肺癌细胞的增敏作用
Beatriz S Matos,Sara Peixoto da Silva,M Helena Vasconcelos et al.
Beatriz S Matos et al.
Aim: Multidrug resistance (MDR) is frequent in non-small cell lung cancer (NSCLC) patients, which can be due to its fibrotic stroma. This work explores the combination of pentoxifylline, an anti-fibrotic and chitinase 3-like-1 (CHI3L1) inhi...
Bernhard Biersack,Michael Höpfner
Bernhard Biersack
Decades ago, the viral myeloblastosis oncogene v-myb was identified as a gene responsible for the development of avian leukemia. However, the relevance of MYB proteins for human cancer diseases, in particular for solid tumors, remained basi...
Mechanisms underlying reversed TRAIL sensitivity in acquired bortezomib-resistant non-small cell lung cancer cells [0.03%]
获得性硼替佐米耐药非小细胞肺癌细胞中反向TRAIL敏感性的机制研究
Leonie De Wilt,Bartosz Kamil Sobocki,Gerrit Jansen et al.
Leonie De Wilt et al.
Aim: The therapeutic targeting of the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) death receptors in cancer, including non-small cell lung cancer (NSCLC), is a widely studied approach for tumor selective apoptotic ...
ALK inhibitors in cancer: mechanisms of resistance and therapeutic management strategies [0.03%]
癌症中的ALK抑制剂：耐药机制和治疗管理策略
Darin Poei,Sana Ali,Shirley Ye et al.
Darin Poei et al.
Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified as potent oncogenic drivers in several malignancies, including non-small cell lung cancer (NSCLC). The discovery of ALK inhibition using a tyrosine kinase inhibitor (...
The therapeutic potential of circular RNA in triple-negative breast cancer [0.03%]
circRNA在三阴性乳腺癌中的治疗潜力研究
Aiqi Xu,Lewei Zhu,Chengcai Yao et al.
Aiqi Xu et al.
Triple-negative breast cancer (TNBC) is among the most aggressive subtypes of the disease that does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Circular RNAs (circRNAs) are a type of n...
Isocucurbitacin B inhibits glioma growth through PI3K/AKT pathways and increases glioma sensitivity to TMZ by inhibiting hsa-mir-1286a [0.03%]
异瓜泊因B通过PI3K/AKT通路抑制胶质瘤生长并抑制hsa-mir-1286a提高胶质瘤对TMZ的敏感性
Mingyu Han,Junsha An,Sui Li et al.
Mingyu Han et al.
Aim: Glioma accounts for 81% of all cancers of the nervous system cancers and presents one of the most drug-resistant malignancies, resulting in a relatively high mortality rate. Despite extensive efforts, the complete treatment options for...
Current knowledge about immunotherapy resistance for melanoma and potential predictive and prognostic biomarkers [0.03%]
免疫治疗抵抗的黑色素瘤的当前研究进展及潜在预测和预后的生物标志物
Lanni Song,Yixin Yang,Xuechen Tian
Lanni Song
Melanoma still reaches thousands of new diagnoses per year, and its aggressiveness makes recovery challenging, especially for those with stage III/IV unresectable melanoma. Immunotherapy, emerging as a beacon of hope, stands at the forefron...
Dysregulation of calcium homeostasis in cancer and its role in chemoresistance [0.03%]
钙稳态失调在癌症中的作用及其对化学疗法耐药性的影响
Neema Kumari,Narasimha Pullaguri,Subha Narayan Rath et al.
Neema Kumari et al.
Globally, cancer, as a major public health concern, poses a severe threat to people's well-being. Advanced and specialized therapies can now cure the majority of people with early-stage cancer. However, emerging resistance to traditional an...
Circular RNA circNCOA3 promotes tumor progression and anti-PD-1 resistance in colorectal cancer [0.03%]
Circular RNA circNCOA3促进结直肠癌肿瘤进展和抗PD-1抵抗作用
Dong-Liang Chen,Nuo Chen,Hui Sheng et al.
Dong-Liang Chen et al.
Aim: Circular RNAs (circRNAs) have been found to be involved in tumor progression, but their role in colorectal cancer (CRC) immune escape remains to be elucidated. Methods: circRNAs differentially expressed in responsive and resistant CRC ...