Burden or Opportunity? Parent Experiences When Approached for Research in a Pediatric Intensive Care Unit [0.03%]
负担还是机会？儿科重症监护室的研究招募家长经历探究
Erin Paquette,Avani Shukla,Jacob Davidson et al.
Erin Paquette et al.
Despite an ongoing need for pediatric research, low study enrollment may impede study completion, particularly in critical care. We conducted a prospective cross-sectional survey and chart review study to assess parent experiences with rese...
A Framework for Assessing Scientific Merit in Ethical Review of Clinical Research [0.03%]
临床研究伦理审查中评估科学价值的框架
Ariella Binik,Spencer Phillips Hey
Ariella Binik
Ethics guidelines and commentary suggest that a central function of research ethics committees is to assess the scientific merit of the protocols they review. However, some commentators object to this role, and evidence suggests that the as...
U.S. Public Health Service STD Experiments in Guatemala (1946-1948) and Their Aftermath [0.03%]
美国公共卫生部在危地马拉进行的性病实验（1946—1948）及其后续事件
Kayte Spector-Bagdady,Paul A Lombardo
Kayte Spector-Bagdady
The U.S. Public Health Service's sexually transmitted disease (STD) experiments in Guatemala are an important case study not only in human subjects research transgressions but also in the response to serious lapses in research ethics. This ...
Jane A Hartsock,Peter H Schwartz,Amy C Waltz et al.
Jane A Hartsock et al.
As pediatric biobank research grows, additional guidance will be needed about whether researchers should always obtain consent from participants when they reach the legal age of majority. Biobanks struggle with a range of practical and ethi...
Humans as Model Organisms [0.03%]
人类作为模式生物
Carolyn P Neuhaus
Carolyn P Neuhaus
Tom Tomlinson,Raymond G De Vries
Tom Tomlinson
Contrary to the revised Common Rule, and contrary to the views of many bioethicists and researchers, we argue that broad consent should be sought for anticipated later research uses of deidentified biospecimens and health information collec...
Cleaning Up the Lab Cages: Healthy Human Phase I Trials and Animal Welfare Requirements [0.03%]
清理实验室笼子：健康的人体I期试验与动物福利要求
Carl Elliott
Carl Elliott
Michael Householder,Ana Laura Solano-López,Derby Muñóz-Rojas et al.
Michael Householder et al.
Costa Rica is a small developing nation in Central America with a well-regarded universal health care system and a strong human rights tradition. In the latter part of the twentieth century, it became a popular site for clinical trials fund...
Widening the Lens [0.03%]
拓宽视野
Karen J Maschke
Karen J Maschke
Advancing Ethics and Policy for Healthy-Volunteer Research through a Model-Organism Framework [0.03%]
借鉴模型生物体框架推动健康志愿者研究中的伦理与政策发展
Jill A Fisher,Rebecca L Walker
Jill A Fisher
Nonhuman animal research and phase I healthy-volunteer clinical trials are both critical components of testing the safety of investigational drugs as part of the development of new pharmaceuticals. In addition, these types of research share...