Policies Regarding the Inclusion of Individuals with Limited English Proficiency: A Cross-Institutional Analysis [0.03%]
关于涵盖英语语言能力有限者的政策的跨机构分析
Neha Mukherjee,Joseph Madour,Theodore Bania et al.
Neha Mukherjee et al.
Individuals with limited English proficiency (LEP) are a rapidly growing social group in the United States, yet they have been historically under-included in clinical research. This is partly due to the fact that research team members typic...
Misaligned Expectations: Motivations of Medically Underserved People to Enroll in the All of Us Research Program [0.03%]
期望偏差：医疗不足者参与“全民研究项目”的动机分析
Carolyn P Neuhaus,Danielle Pacia,Camila Salvagno et al.
Carolyn P Neuhaus et al.
It is important to know what motivates people, especially from groups underrepresented in biomedical research, to accept or decline participation in research studies. With this information, engagement strategies, incentives to participate, ...
Organ Chips and Translational Research: Identifying and Examining New Ethical Issues [0.03%]
器官芯片与转化研究：识别和探讨新的伦理问题
Melanie Jeske
Melanie Jeske
Organ chips, also known as organ-on-a-chip devices, tissue chips, or microphysiological systems, have emerged over the last decade as a promising translational technology amidst growing concern about the translational crisis between laborat...
Including Research Subjects without Decision-Making Capacity Only as Last Resort [0.03%]
在别无他法时才把缺乏决策能力的研究对象纳入研究范围
Linus Broström,Anna Nilsson
Linus Broström
The aim of this paper is to discuss the ethical and legal justification of the broadly accepted ethical principle that researchers may not include adults without decision-making capacity to consent to participating in research studies if th...
Perspectives of Information Access in the Informed Consent Process for Clinical Research Participation in Australia [0.03%]
澳大利亚临床研究知情同意过程中的信息获取视角
Fleur O&#x;Hare,Lauren N Ayton,David Foran et al.
Fleur O&#x;Hare et al.
Access to communication and information during the informed consent process for clinical research is essential for empowered decision-making. To build awareness of accessibility practices, this study aimed to explore current enablers and ba...
Human Research Protections during Emergencies: An Integrative Review [0.03%]
紧急状态下的生物医学研究中的伦理审查及人体受试者保护：综述型研究论文
Lauren M Sauer,Megan K Singleton,Andrew Stolbach et al.
Lauren M Sauer et al.
The increasing frequency and severity of various types of societal and humanitarian emergencies-e.g., infectious disease outbreaks and natural disasters-creates unique challenges for conducting human subjects research in these settings. The...
Ten Questions for Ethics Committees Evaluating the Strength of Evidence in Support of Early Phase Trials [0.03%]
伦理委员会评估早期临床试验支持证据强度的十个问题
Spencer Phillips Hey,Mark Fedyk,Jonathan Kimmelman
Spencer Phillips Hey
Assessing the risks and benefits of early-phase clinical trials presents a persistent challenge for research ethics committees. These trials often lack direct, supporting evidence of clinical safety and efficacy, requiring ethics reviewers ...
Digital Twins in Translational Research and Health Care: An Anthropological Perspective [0.03%]
数字化双胞胎在转化研究和医疗保健中的应用：一种人类学视角
Jennifer K Wagner
Jennifer K Wagner
In this essay, I consider the "social life" of digital twins in translational medicine, exploring how the United States is culturally unprepared for the arrival of digital twins at whole person scales. By looking more closely at our anticip...
Addressing Incidental Findings in Neuroimaging Studies: Never Easy, Rarely Rescue [0.03%]
神经影像研究中偶发发现的处理：从未简单，鲜有转机
Hayden P Nix
Hayden P Nix
Population-wide neuroimaging studies reveal brain lesions in approximately 3% of putatively healthy research participants. It is unclear how researchers ought to address this problem and whether they should seek out incidental findings. Kop...
Emergency Care Research and Exception from Informed Consent: Addressing the Spectrum of Capacity for Consent [0.03%]
紧急护理研究和知情同意豁免：解决同意能力的范围问题
Neal W Dickert,Sara F Goldkind,Graham Nichol et al.
Neal W Dickert et al.
Emergency care research conducted under exception from informed consent (EFIC) involves confronting well-known ethical and practical challenges. There has been significant experience addressing those challenges, but most of this experience ...