Franklin G Miller,Jonathan D Moreno
Franklin G Miller
In the midst of the Covid-19 pandemic, ethicists, researchers, and journalists have recommended studies that deliberately infect healthy volunteers with the coronavirus as a scientific means of expediting vaccine development. In this essay,...
Balancing External Validity and Concern for Psychosocial Harms in Translational Genetic Research [0.03%]
遗传转化研究中平衡外部有效性与心理社会危害的关系
Jessica Mozersky,Michelle N Meyer,Alanna Kulchak Rahm et al.
Jessica Mozersky et al.
Ayesha Bhatia,Paul S Appelbaum,Katherine L Wisner
Ayesha Bhatia
A pregnant woman was enrolled in a double-blind randomized controlled trial (RCT) in which participants were randomized to a placebo or a drug being tested to prevent a hypertensive complication. After completing the trial, the research par...
Case Reports
Ethics & human research. 2021 Mar;43(2):28-34. DOI:10.1002/eahr.500084 2021
Phoebe Friesen,Rachel Douglas-Jones,Mason Marks et al.
Phoebe Friesen et al.
Many are calling for concrete mechanisms of oversight for health research involving artificial intelligence (AI). In response, institutional review boards (IRBs) are being turned to as a familiar model of governance. Here, we examine the IR...
The Ethics of Repurposing Previously Collected Research Biospecimens in an Infectious Disease Pandemic [0.03%]
传染病大流行期间重新利用先前采集的研究生物样本的伦理问题
Benjamin E Berkman,Anna C Mastroianni,Leila Jamal et al.
Benjamin E Berkman et al.
In the early days of a pandemic, repurposing biospecimens from established research projects could prove to be extraordinarily useful in achieving substantial and timely public health benefits. Nonetheless, there are potential ethical and r...
Holly Fernandez Lynch,Dawn Lundin,Emma A Meagher
Holly Fernandez Lynch
Employees are often considered a vulnerable research population due to concerns about consent and confidentiality, but there is insufficient guidance regarding their ethical inclusion in research. In the context of Covid-19, frontline healt...
Should Participants in Clinical Trials Be Able to Withdraw from Passive Follow-Up? [0.03%]
临床试验受试者能否退出被动随访？
Warren H Capell,Matthew K Wynia,Elisa A Hurley et al.
Warren H Capell et al.
A research participant's right to withdraw from all research procedures is widely accepted, but there can be justifiable limits to a participant's exercise of autonomy to withdraw from some procedures. Clinical outcomes trials depend on com...
Should the Regulation of Research Misconduct Be Integrated with the Ethics Framework Promulgated in The Belmont Report? [0.03%]
应当将科研不当行为的规范纳入贝尔蒙报告中的伦理框架吗？
Barbara K Redman,Arthur L Caplan
Barbara K Redman
The federal research misconduct regulations finalized in 2005 did not incorporate important principles regarding human subjects protections articulated in The Belmont Report, yet research misconduct can involve harms to research subjects an...
Christopher Robertson
Christopher Robertson
In prospective interventional research, a treatment may provide an advantage for the recipient over other people who do not receive it. If the intervention proves successful, the treated are better able to compete for such things as a scarc...
What Factors Predict Willingness to Join Low-Risk Pragmatic Clinical Trials? [0.03%]
什么因素预测参与低风险实用临床试验的意愿？
Stephanie R Morain,Nancy E Kass,Ruth R Faden
Stephanie R Morain
Pragmatic clinical trials (PCTs) may improve the efficiency, relevance, and representativeness of research. While prior research has indicated that willingness to join a PCT is high, it is not universal among those asked in surveys explorin...