Challenges and Possible Solutions to Adapting to Virtual Recruitment: Lessons Learned from a Survey Study during the Covid-19 Pandemic [0.03%]
新冠疫情下在线招聘的挑战与解决方案：一项调查研究及其启示
Krista E Cooksey,Jessica Mozersky,James DuBois et al.
Krista E Cooksey et al.
The Covid-19 pandemic required rapid changes to research protocols, including immediate transitions to recruiting research participants and conducting the informed consent process virtually. This case study details the challenges our resear...
Participants' Perspectives on Payment for Research Participation: A Qualitative Study [0.03%]
关于研究参与付费的受试者视角：定性研究报告
Emily A Largent,Whitney Eriksen,Frances K Barg et al.
Emily A Largent et al.
Investigators commonly offer payments to research participants to promote recruitment and retention. Yet the ethics of offering monetary incentives to research participants continues to be debated. Prior conceptual work has addressed some o...
Demonstration Project: Transitioning a Research Network to New Single IRB Platforms [0.03%]
示范项目：研究网络过渡到新的单一IRB平台
Jeri S Burr,Ann Johnson,Annie Risenmay et al.
Jeri S Burr et al.
Since the 2016 National Institutes of Health (NIH) mandate to use a single IRB (sIRB) in multicenter research, institutions have struggled to operationalize the process. In this demonstration project, the University of Utah Trial Innovation...
Multicenter Study
Ethics & human research. 2022 Nov;44(6):32-38. DOI:10.1002/eahr.500149 2022
Ethical Frameworks for Disclosure of Alzheimer Disease Biomarkers to Research Participants: Conflicting Norms and a Nuanced Policy [0.03%]
阿尔茨海默病生物标志物研究参与者的披露伦理框架：规范冲突与细致政策
Eline M Bunnik,Marthe Smedinga,Richard Milne et al.
Eline M Bunnik et al.
More and more frequently, clinical trials for Alzheimer disease (AD) are targeting cognitively unimpaired individuals who are at increased risk of developing the disease. It is not always clear whether AD biomarker information should be dis...
Sergio G Litewka,Jonathan D Moreno
Sergio G Litewka
The Russian invasion of Ukraine has led to the imposition of economic sanctions intended to isolate Russia from much of global commerce, which implicitly includes the medical research enterprise. The prospect of ongoing isolation of Russia'...
Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials [0.03%]
改善一期健康志愿者试验中的受试者保护的伦理标准
Rebecca L Walker,Douglas MacKay,Margaret Waltz et al.
Rebecca L Walker et al.
Phase I healthy volunteer trials test the safety and tolerability of investigational pharmaceuticals. In them, participants are exposed to study-drug risks without the possibility of direct medical benefit and typically must spend days or w...
Lisa E Smilan
Lisa E Smilan
Biobanks and health data repositories provide rich reservoirs of information for use in biomedical research. These repositories depend on participants donating identifiable health data and biospecimens that may be used in perpetuity by unli...
Informed Consent for Placebo-Controlled Trials: Do Ethics and Science Conflict? [0.03%]
安慰剂对照试验中的知情同意：伦理与科学冲突吗？
Hope A Feldman,James A Feldman,Charles C Miller et al.
Hope A Feldman et al.
The use of a placebo has been considered the best method for controlling bias in a prospective randomized clinical trial and provides the most rigorous test of treatment efficacy for evaluating a medical therapy. Placebos commonly produce c...
Randomized Controlled Trial
Ethics & human research. 2022 Sep;44(5):42-48. DOI:10.1002/eahr.500142 2022
Laura A Levit,Julie Kaneshiro,Jeffrey Peppercorn et al.
Laura A Levit et al.
Research biopsies included in cancer clinical trials have the goal of advancing scientific understanding of the biological bases of cancer and its treatments, but may offer no prospect of direct benefit to participants and often pose more t...
Published Erratum
Ethics & human research. 2022 Sep;44(5):21. DOI:10.1002/eahr.500138 2022