Disclosing Conflicts of Interest to Potential Research Participants: Good for Nothing? [0.03%]
告知受试者利益冲突：毫无作用吗？
Inmaculada de Melo-Martín
Inmaculada de Melo-Martín
The growing commercialization of science has raised concerns about financial conflicts of interest (COIs). Evidence suggests that such conflicts threaten the integrity of research and the well-being of research participants. Trying to minim...
Factors That Impact Hospital-Specific Enrollment Rates for a Neonatal Clinical Trial: An Analysis of the HEAL Study [0.03%]
影响新生儿临床试验入组率的因素：HEAL研究分析
Katherine F Guttmann,Sijia Li,Yvonne W Wu et al.
Katherine F Guttmann et al.
Inconsistent enrollment among hospitals for neonatal clinical trials may lead to study populations that are not representative of the patient population in the neonatal intensive care unit. The High-Dose Erythropoietin for Asphyxia and Ence...
Randomized Controlled Trial
Ethics & human research. 2023 Jan;45(1):29-38. DOI:10.1002/eahr.500154 2023
Public Policy Experiments without Equipoise: When Is Randomization Fair? [0.03%]
无均衡的公共政策实验：随机化何时才是公平的？
Douglas MacKay,Emma Cohn
Douglas MacKay
Government agencies and nonprofit organizations have increasingly turned to randomized controlled trials (RCTs) to evaluate public policy interventions. Random assignment is widely understood to be fair when there is equipoise; however, som...
Can the Research Team-Participant Relationship Ground Ancillary-Care Obligations? [0.03%]
研究团队与参与者的关系能否成为附属医疗责任的基础？
Henry S Richardson
Henry S Richardson
Discussion of medical researcher teams' ancillary-care obligations has long been dominated by partial-entrustment theory, developed in 2004 by the author of this article, in collaboration with Leah Belsky. Critics of the limited scope of th...
Challenges and Possible Solutions to Adapting to Virtual Recruitment: Lessons Learned from a Survey Study during the Covid-19 Pandemic [0.03%]
新冠疫情下在线招聘的挑战与解决方案：一项调查研究及其启示
Krista E Cooksey,Jessica Mozersky,James DuBois et al.
Krista E Cooksey et al.
The Covid-19 pandemic required rapid changes to research protocols, including immediate transitions to recruiting research participants and conducting the informed consent process virtually. This case study details the challenges our resear...
Participants' Perspectives on Payment for Research Participation: A Qualitative Study [0.03%]
关于研究参与付费的受试者视角：定性研究报告
Emily A Largent,Whitney Eriksen,Frances K Barg et al.
Emily A Largent et al.
Investigators commonly offer payments to research participants to promote recruitment and retention. Yet the ethics of offering monetary incentives to research participants continues to be debated. Prior conceptual work has addressed some o...
Demonstration Project: Transitioning a Research Network to New Single IRB Platforms [0.03%]
示范项目：研究网络过渡到新的单一IRB平台
Jeri S Burr,Ann Johnson,Annie Risenmay et al.
Jeri S Burr et al.
Since the 2016 National Institutes of Health (NIH) mandate to use a single IRB (sIRB) in multicenter research, institutions have struggled to operationalize the process. In this demonstration project, the University of Utah Trial Innovation...
Multicenter Study
Ethics & human research. 2022 Nov;44(6):32-38. DOI:10.1002/eahr.500149 2022
Ethical Frameworks for Disclosure of Alzheimer Disease Biomarkers to Research Participants: Conflicting Norms and a Nuanced Policy [0.03%]
阿尔茨海默病生物标志物研究参与者的披露伦理框架：规范冲突与细致政策
Eline M Bunnik,Marthe Smedinga,Richard Milne et al.
Eline M Bunnik et al.
More and more frequently, clinical trials for Alzheimer disease (AD) are targeting cognitively unimpaired individuals who are at increased risk of developing the disease. It is not always clear whether AD biomarker information should be dis...
Sergio G Litewka,Jonathan D Moreno
Sergio G Litewka
The Russian invasion of Ukraine has led to the imposition of economic sanctions intended to isolate Russia from much of global commerce, which implicitly includes the medical research enterprise. The prospect of ongoing isolation of Russia'...
Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials [0.03%]
改善一期健康志愿者试验中的受试者保护的伦理标准
Rebecca L Walker,Douglas MacKay,Margaret Waltz et al.
Rebecca L Walker et al.
Phase I healthy volunteer trials test the safety and tolerability of investigational pharmaceuticals. In them, participants are exposed to study-drug risks without the possibility of direct medical benefit and typically must spend days or w...