Perspectives of Information Access in the Informed Consent Process for Clinical Research Participation in Australia [0.03%]
澳大利亚临床研究知情同意过程中的信息获取视角
Fleur O&#x;Hare,Lauren N Ayton,David Foran et al.
Fleur O&#x;Hare et al.
Access to communication and information during the informed consent process for clinical research is essential for empowered decision-making. To build awareness of accessibility practices, this study aimed to explore current enablers and ba...
Human Research Protections during Emergencies: An Integrative Review [0.03%]
紧急状态下的生物医学研究中的伦理审查及人体受试者保护：综述型研究论文
Lauren M Sauer,Megan K Singleton,Andrew Stolbach et al.
Lauren M Sauer et al.
The increasing frequency and severity of various types of societal and humanitarian emergencies-e.g., infectious disease outbreaks and natural disasters-creates unique challenges for conducting human subjects research in these settings. The...
Ten Questions for Ethics Committees Evaluating the Strength of Evidence in Support of Early Phase Trials [0.03%]
伦理委员会评估早期临床试验支持证据强度的十个问题
Spencer Phillips Hey,Mark Fedyk,Jonathan Kimmelman
Spencer Phillips Hey
Assessing the risks and benefits of early-phase clinical trials presents a persistent challenge for research ethics committees. These trials often lack direct, supporting evidence of clinical safety and efficacy, requiring ethics reviewers ...
Digital Twins in Translational Research and Health Care: An Anthropological Perspective [0.03%]
数字化双胞胎在转化研究和医疗保健中的应用：一种人类学视角
Jennifer K Wagner
Jennifer K Wagner
In this essay, I consider the "social life" of digital twins in translational medicine, exploring how the United States is culturally unprepared for the arrival of digital twins at whole person scales. By looking more closely at our anticip...
Addressing Incidental Findings in Neuroimaging Studies: Never Easy, Rarely Rescue [0.03%]
神经影像研究中偶发发现的处理：从未简单，鲜有转机
Hayden P Nix
Hayden P Nix
Population-wide neuroimaging studies reveal brain lesions in approximately 3% of putatively healthy research participants. It is unclear how researchers ought to address this problem and whether they should seek out incidental findings. Kop...
Emergency Care Research and Exception from Informed Consent: Addressing the Spectrum of Capacity for Consent [0.03%]
紧急护理研究和知情同意豁免：解决同意能力的范围问题
Neal W Dickert,Sara F Goldkind,Graham Nichol et al.
Neal W Dickert et al.
Emergency care research conducted under exception from informed consent (EFIC) involves confronting well-known ethical and practical challenges. There has been significant experience addressing those challenges, but most of this experience ...
Bioethicists' Perspectives on Ethical Research: Results of the "Views in Bioethics Survey" [0.03%]
生物学家关于伦理研究的观点：“生物伦理调查”的结果
Leah Pierson,Leila Orszag,Sophie Gibert et al.
Leah Pierson et al.
Health research plays a crucial role in advancing medicine and public health, but ethical constraints shape its conduct. This study presents findings from the Views in Bioethics Survey (VIBeS), the first large-scale systematic survey of bio...
Institutional Review Board Obligations Regarding Study Funding Sufficiency [0.03%]
关于研究资金充足性的机构审查委员会义务
Holly Fernandez Lynch,Tasneem Mohammad
Holly Fernandez Lynch
Given their obligations to ensure ethical research, we argue that institutional review boards (IRBs) bear a responsibility to minimize the possibility that proposed clinical studies will terminate early for insufficient funding. Underfunded...
Mandating Evidence-Based Informed Consent Practices: A Critical Engagement with IRB Leader Focus Group Findings [0.03%]
有关IRB领导者焦点小组发现的基于证据的知情同意实践的批判性参与强制性研究
Meredith V Parsons,Erin D Solomon,Kari Baldwin et al.
Meredith V Parsons et al.
Evidence-based informed consent practices-such as writing in plain language, formatting for readability, and assessing understanding using validated instruments-are underutilized in research practice. Yet the Common Rule does not specifical...
Exception from Informed Consent and Waiver of Informed Consent for Comparative Effectiveness Trials in Emergency Care Research [0.03%]
急诊护理研究中的知情同意豁免和比较有效性试验的知情同意放弃政策
Jonathan D Casey,Matthew W Semler,Jeremy Brown et al.
Jonathan D Casey et al.
For many of the decisions made in the clinical care setting, clinicians lack evidence to inform which treatment would result in the best patient outcomes. This problem is particularly common in emergency care, a field in which the condition...