Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease [0.03%]
抗TNF治疗失败的理解：既存的抗药抗体常见，但在体外不能使药物失活或影响克罗恩病患者英夫利昔注射液和阿达木单抗的临床疗效
Rachel Nice,Simeng Lin,Neil Chanchlani et al.
Rachel Nice et al.
Background: We sought to determine the prevalence, clinical impact, neutralizing capacity, and cross-reactivity of pre-existing antibodies to infliximab and adalimumab in antitumor necrosis factor (TNF) treatment-naïve p...
Seema Khattri Bhandari,Shu-Ling Fan
Seema Khattri Bhandari
Background: Arginine vasopressin (AVP) is a neuroendocrine hormone essential for fluid balance, vascular tone, and the endocrine stress response. However, its clinical measurement is limited by instability and technical c...
Genetic Causes of Hereditary Myopathies in a Cohort of Male Patients: Molecular Diagnosis in Myopathies [0.03%]
遗传性肌病男性患者基因病因分析及分子诊断
Paola Ayala-Ramírez,Mary García-Acero,Mariana Guerra-Torres et al.
Paola Ayala-Ramírez et al.
Background: Hereditary myopathies are a heterogeneous group of genetic disorders affecting skeletal muscle. The molecular diagnosis of these conditions has been revolutionized by next-generation sequencing (NGS), signific...
The Preanalytical Process Matters: Impact of Blood Collection Tubes on the Measurement of Vitamin D Using Liquid Chromatography Tandem Mass Spectrometry [0.03%]
采样过程不容忽视：血液收集管对液相色谱串联质谱法测定维生素D的影响
Sae Ochi,Akihiro Kunisawa,Tomokazu Matsuura et al.
Sae Ochi et al.
Background: Liquid chromatography tandem mass spectrometry (LC-MS/MS) is a highly sensitive analytical tool that has become the gold standard for measuring the concentrations of some steroidal hormones and therapeutic dru...
Reevaluating Ferritin Reference Intervals: Defining Limits Based on Iron-Sufficient Population Studies, Clinical Relevance, and Healthcare Efficiency [0.03%]
重新评估铁蛋白参考区间：基于铁充足人群研究、临床意义和卫生经济学定义限值
Jillian Kodger,Joe El-Khoury,Nalan Yurtsever
Jillian Kodger
Evolving Insights Regarding Biomarkers to Better Manage Older Adults With Cardiovascular Disease [0.03%]
关于生物标志物的新兴见解，以更好地管理心血管疾病老年患者
Mohamad B Moumneh,Daniel E Forman,Abdulla A Damluji et al.
Mohamad B Moumneh et al.
Background: Aging is associated with subclinical changes in cardiac structure and function as well as an increase in prevalent cardiovascular disease and geriatric syndromes such as frailty and sarcopenia. This can result...
Design and Analytical Evaluation of an Immunoassay for Long Forms of Cardiac Troponin T [0.03%]
心肌肌钙蛋白T长链型免疫测定的设计及分析评估
Rami Aalto,Akseli Lahtinen,K E Juhani Airaksinen et al.
Rami Aalto et al.
Background: Cardiac troponins (cTn) are used as diagnostic biomarkers of acute myocardial infarction (MI), but elevated levels of cTn can also be observed in other conditions. We report here the design and analytical eval...
Influence of Protein Glycosylation on the Measurement of Soluble Urokinase Plasminogen Activator Receptor [0.03%]
蛋白质糖基化对可溶性乌司他丁尿激酶型血浆素激活物受体测定的影响
Jaya Montecillo,Richard W Troughton,A Mark Richards et al.
Jaya Montecillo et al.
Background: Elevated concentrations of the glycoprotein soluble urokinase plasminogen activator receptor (suPAR) predict worse cardiovascular disease (CVD) outcomes. However, glycosylation effects on its measurement are u...
Blister and Bite Red Blood Cells as Diagnostic Beacons in Acute Hemolytic Anemia [0.03%]
急性溶血性贫血诊断中的红细胞 blister和bite征象
Roopa Kodimyala,Samir B Kahwash,Jingcai Wang
Roopa Kodimyala