Why Metrological Traceability Matters in Medical Laboratory Diagnostics [0.03%]
计量溯源性在医学实验室诊断中的重要性不容忽视
Marith van Schrojenstein Lantman,Christa Cobbaert,Mauro Panteghini et al.
Marith van Schrojenstein Lantman et al.
Application of the results provided by medical laboratories plays an essential role in medical decision-making. This is not limited to diagnosis and monitoring of disease but also involves its use in other phases of the health continuum, e....
Multi-Site Validation of a Newly FDA-Cleared Automated Methotrexate Immunoassay for Therapeutic Drug Monitoring [0.03%]
用于治疗药物监测的 automated methotrexate 免疫测定法多中心验证试验获得 FDA 批准
Shaimaa Maher,Vincent Buggs,Patrick Ravelo et al.
Shaimaa Maher et al.
Background: Methotrexate (MTX), a synthetic antimetabolite and folic acid antagonist, has become a cornerstone in the management of malignant diseases. However, MTX toxicity can be severe and potentially life-threatening,...
Validation of Plasma Free Hemoglobin Testing for Extracorporeal Membrane Oxygenation (ECMO) Patients [0.03%]
用于体外膜氧合(ECMO)患者的血浆游离血红蛋白检测验证研究
Meshach Asare-Werehene,Mary Kathryn Bohn,Bianca Wan et al.
Meshach Asare-Werehene et al.
Background: Circuit-induced hemolysis is relatively common in extracorporeal membrane oxygenation (ECMO) patients. Intravascular release of cell-free hemoglobin can lead to complications and requires timely recognition. V...
Comparison of a Reformulated Automated Vitamin D Assay, Its Predecessor, and 2 Contemporary Formulations [0.03%]
改良型自动化维生素D检测方法及其前一代和当前其他两种测定法的比较
K Aaron Geno,Yasel F Alvarez,Jacqueline A Hubbard et al.
K Aaron Geno et al.
Background: Historically, 25-hydroxyvitamin D (25OHD) assays have under- or over-recovered 25-hydroxyvitamin D2 (25OHD2), but assay manufacturers have modified their reagents to address this problem. In this study, we com...
Cardiac Troponin Thresholds in Children and Young Adults: A Multi-Center Cohort Study [0.03%]
儿童和青年人群中心脏肌钙蛋白阈值的多中心队列研究
Alexander J F Thurston,Eirik Å Røys,Ragnhild Røysland et al.
Alexander J F Thurston et al.
Background: The role of high-sensitivity cardiac troponin (cTn) assays for children and young adults is uncertain, and no guidance is available on diagnostic thresholds. This study evaluates the effect of applying pediatr...
Evaluation of Serum Kappa Free Light Chain Reference Interval Using a New Stabilized Calibrator [0.03%]
采用新型稳定校准品测定血清κ游离轻链参考区间及评价
Derek Waggoner,Katie Thoren,Robert Maynard et al.
Derek Waggoner et al.
Background: Measurement of serum free light chains (FLC) including kappa FLC, lambda FLC, and calculated kappa to lambda FLC ratio play a vital role in the diagnosis, prognosis, and monitoring of plasma cell disorders. Re...
Comparison of the Friedewald, Sampson, and Martin Formulas with Direct Homogeneous Assay of Low-Density Lipoprotein Cholesterol in South American Patients [0.03%]
南美患者的弗里德瓦尔德、桑普森和马丁公式与低密度脂蛋白胆固醇直接均相测定的比较
Nahuel Fernandez Machulsky,Dario Jacobsen,Abi Cardozo Madaf et al.
Nahuel Fernandez Machulsky et al.
Background: Increases in obesity and hypertriglyceridemia worldwide, together with lower LDL cholesterol (LDL-c) values from new lipid-lowering agents, prompted the development of new estimation formulas including Martin ...
Detection of PD-1 and CD28 Expression in Lymphocytes by Flow Cytometry [0.03%]
流式细胞术检测淋巴细胞PD-1和CD28的表达
Shuying Chen,Xiang Wu,Yiting Tang et al.
Shuying Chen et al.
Background: Cancer immunotherapy research, immune microenvironment exploration, and biomarker discovery are key application areas of immune checkpoint analysis. PD-1 and CD28 are crucial receptors expressed on the surface...
Assessing the Clinical Performance of a Presymptomatic Acute Graft-Versus-Host Disease Biomarker Test in Hematopoietic Stem Cell Transplant Recipients [0.03%]
造血干细胞移植受者前症状急性移植物抗宿主病生物标志物检测的临床性能评估
Lin Wang,Rafael C Pulgrossi,Jaclyn Anderson et al.
Lin Wang et al.
Background: Acute graft-versus-host disease (aGVHD) is a common complication of allogenic hematopoietic cell transplantation (HCT). The aGVHD presymptomatic algorithm is comprised of 2 serum biomarkers, suppression of tum...
Health Literacy/Numeracy-Related Factors Affecting Interpretation of Medical Laboratory Values [0.03%]
影响医学实验室检验结果解读的健康素养/数字素养相关因素
Rachel L Childs
Rachel L Childs
Background: Health literacy and numeracy are broad terms that relate to a patient's understanding of their health information. While there is a substantial amount of research on this topic in a general sense as well as in...