Methemoglobin-Encapsulating Liposome: A Low-Risk Intravascular Contrast Agent for Magnetic Resonance Imaging [0.03%]
一种低风险的用于磁共振成像的血管内对比剂——包载高铁血红蛋白脂质体
Kazuaki Taguchi,Akira Sumiyoshi,Yuto Suzuki et al.
Kazuaki Taguchi et al.
Hemoglobin shows different contrasts on magnetic resonance imaging (MRI) depending on the iron and oxygenation states of heme. Functional brain MRI utilizes the differences in the concentrations of oxyhemoglobin and deoxyhemoglobin in cereb...
Ahmed M Salama,John G Hardy,Abdurohman Mengesha Yessuf et al.
Ahmed M Salama et al.
Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their a...
Deep-Red Cyanine-Based Fluorescent Probes with 6-Quinolinium Acceptors for Mitochondrial NAD(P)H Imaging in Live Cells and Human Diseased Kidney Tissues [0.03%]
基于深红菁和喹啉𬭩盐的比率型荧光探针用于活细胞及人肾组织内NAD(P)H成像研究
Dilka Liyana Arachchige,Sushil K Dwivedi,Peter Agyemang et al.
Dilka Liyana Arachchige et al.
We developed two deep-red cyanine chromophores, probes A and B, for selective mitochondrial NAD(P)H detection in live cells. Probe A features a 1,2,3,3-tetramethyl-3H-indolium core, while probe B incorporates a 1,1,2,3-tetramethyl-1H-benzo[...
Noninvasive Transdermal Delivery of STING Agonists Reshapes the Immune Microenvironment of Melanoma and Potentiates Checkpoint Blockade Therapy Efficacy [0.03%]
经皮递送sting激动剂非侵入性治疗重塑黑色素瘤免疫微环境并增强检控阻断疗法疗效
Junjie Zhang,Hui Yang,Liang Li et al.
Junjie Zhang et al.
The emergence of immunotherapy as a revolutionary therapeutic modality has fostered confidence and underscored its potent efficacy in tumor therapy. However, enhancing the therapeutic efficacy of immunotherapy by precise and judicious admin...
Biomimetic Copper-Based Nanoplatform for Enhanced Tumor Targeting and Effective Melanoma Therapy [0.03%]
一种仿生的铜基纳米平台用于增强肿瘤靶向及有效治疗黑色素瘤
Hagar Shendy Bahlol,Kai Zhang,Jiamin Deng et al.
Hagar Shendy Bahlol et al.
Designing advanced biomimetic nanoplatforms that combine photothermal therapy (PTT) and immune activation represents a modern approach to addressing the challenges of cancer therapy. This study presents a nanobiomimetic hollow copper-sulfid...
Wound Tissue Regeneration by Microfluidic Generated Fibroblast Cell/CuO Nanosheet-Loaded Alginate Hydrogel on an Excisional Full-Thickness Rat Model [0.03%]
微流控生成的成纤维细胞/氧化铜纳米片载藻酸盐水凝胶在全层切除伤模型中的创面组织修复研究
Zahra Oushyani Roudsari,Keivan Nedaei,Mahmood Araghi et al.
Zahra Oushyani Roudsari et al.
Chronic ulcers present numerous challenges in treatment such as prolonged inflammation, infections resistant to drugs, and the formation of scars. In this research, we developed a calcium ion (Ca2+) cross-linked alginate (Alg) hydrogel load...
CoCu@NC Nanozyme with pH-Switchable and Dual Enzymatic Activity: Highly Sensitive Colorimetric Sensing of Doxorubicin and Naked-Eye Detection of H2O2-Induced DNA Damage [0.03%]
具有pH可控和双重酶活性的CoCu@NC纳米酶：多柔比星的高灵敏度比色检测及H2O2致DNA损伤的裸眼检测
Azita Mohammadi,Rezgar Ahmadi,Abdollah Salimi et al.
Azita Mohammadi et al.
The development of nanomaterials with multienzyme activity for advanced sensing and biosensing assays has attracted attention. In this study, a Cu-Co bimetallic nitrogen-doped carbon catalyst (CoCu@NC) was synthesized. The prepared nanomate...
Investigation of Structural, Optical, Electrical, and Biological Properties of a Porous Platinum Electrode for Neurostimulation Devices [0.03%]
用于神经刺激设备的多孔铂电极的结构、光学、电气和生物性能研究
Lee-Woon Jang,Jeong-Hun Kim,Wonseok Lee et al.
Lee-Woon Jang et al.
The structural and optical properties, as well as the electrical and biological characteristics of a porous platinum (Pt) structure for neurostimulation applications, are investigated. Critical factors such as biocompatibility, electrical p...
Dual-Mode RPA/CRISPR-Cas12a Biosensor Based on Silica and Magnetic Hybrid Nanobeads for Rapid Detection of Campylobacter jejuni [0.03%]
基于 silica 和磁性混合纳米珠的双模式 RPA / CRISPR-Cas12a 生物传感器快速检测空肠弯曲菌
Fareeha Arshad,Anis Nadiah Abdillah,Pooja Shivanand et al.
Fareeha Arshad et al.
In this study, we developed a biosensor that makes use of recombinase polymerase amplification (RPA) along with a CRISPR/Cas12a system integrated with silica nanobeads and a magnetic nanoparticle nanohybrid complex that displayed peroxidase...
Emerita Analoga Shell-Derived CS/GO Composite Incorporated into a Biomimetic PAN Nanofiber Membrane for Enhanced Bone Tissue Regeneration [0.03%]
基于Emerita Analoga贝壳的CS/GO复合材料掺入仿生PAN纳米纤维膜以增强骨组织再生
Balaganesh Danagody,Neeraja Bose,Swathi Sudhakar et al.
Balaganesh Danagody et al.
Bone regeneration is a process that aims to restore the structure and function of damaged bone tissues. Modern approaches for bone regeneration involve a combination of strategies, including tissue engineering and biomaterials, to promote h...