Design and Photophysical Engineering of Functional Organic Luminogens for Precision Cancer Theranostics [0.03%]
Priyam Ghosh,Parameswar Krishnan Iyer
Priyam Ghosh
Cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. Functional organic luminogens have emerged as a versatile class of biomaterials for cancer theranostics, enabling the integration of diag...
Dissolving Amyloid Fibrils with Natural Deep Eutectic Solvents: Citric Acid-Glycerol Achieves Superior Solubilization and Partial Protein Refolding [0.03%]
Sora Hirano,Tatsuya Oshima,Asuka Inada et al.
Sora Hirano et al.
Amyloid protein aggregates pose a significant challenge due to their extreme insolubility and association with neurodegenerative diseases. To identify effective solvents for dissolving amyloid-forming proteins, a screening of deep eutectic ...
Smart Macrocycles: Cyclodextrin-Porphyrin Photosensitizers for Photodynamic Therapy in Human Bladder Cancer Cells [0.03%]
Cláudia P S Ribeiro,Rosa Fernandes,Leandro M O Lourenço
Cláudia P S Ribeiro
Urothelial carcinoma of the bladder is one of the most common malignancies of the urinary tract. It remains a therapeutic challenge due to its high recurrence rate and resistance to conventional treatments. Photodynamic therapy (PDT) is an ...
Chair-Shaped Indoline Donor Enabling Near-Infrared Imaging-Guided Type I Photodynamic Therapy [0.03%]
Guofeng Yi,Qiqi Xu,Haodong Liu et al.
Guofeng Yi et al.
Imaging-guided photodynamic therapy (PDT) represents a promising treatment modality owing to its high precision and minimal invasiveness. However, insufficient oxygen supply within solid tumors and aggregation-caused quenching (ACQ) of phot...
Anti-Breast Cancer Effects of Carbon Quantum Dots: In Vivo Angiogenesis and Arginase Co-Inhibition [0.03%]
Gurmeet Singh,Somedutta Maity,Desh Deepak Yadav et al.
Gurmeet Singh et al.
Breast cancer evades the immune system through immune-regulating enzymes. One of them is arginase, primarily produced in tumor-resident cells, especially by tumor-associated macrophages and myeloid-derived suppressor cells. This helps malig...
Triple-Synergistic Therapy with Cobalt-Pheophytin Coordination Micelles for Overcoming Drug Resistance in Pancreatic Cancers [0.03%]
Zhen Jiang,Yue Pan,Gengqi Liu et al.
Zhen Jiang et al.
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies as KRAS (Kirsten rat sarcoma viral oncogene homolog) mutations continuously activate multiple downstream signaling pathways, leading to drug resistance. To...
Codelivery of Doxorubicin and Carvacrol via a β-Cyclodextrin-Hyaluronic Acid Nanogel System for Targeted and Stimuli-Responsive Anticancer Therapy [0.03%]
Lakshmi Sathi Devi,Maria Beatrice Morelli,Consuelo Amantini et al.
Lakshmi Sathi Devi et al.
Nanogel systems offer transformative potential in overcoming critical challenges of traditional therapies, such as poor solubility, low bioavailability, and systemic toxicity. In this study, nanogels were developed using thiolated hyaluroni...
Multitargeted Anticancer Strategy through DNA Damage and Mitochondrial Collapse by a Ferrocene-Benzimidazolium Salt [0.03%]
Nitisha Beniwal,Bikash Lahkar,Girbide Amitkumar Ramakant et al.
Nitisha Beniwal et al.
The development of targeted and selective organometallic anticancer drugs is a primary emphasis in contemporary chemotherapeutic research. We provide the synthesis and thorough biological assessment of a new benzimidazolium-derived ferrocen...
Glucose-Responsive Antibacterial Nanogel for Synergistic Dual-Mode Therapy of Diabetic Wound Infections via Enhancing Cascade Generation of Hydroxyl Radicals and Hypoxia-Induced Activation of Metronidazole [0.03%]
Yinbang Zheng,Weiqing Hu,Yuze Luo et al.
Yinbang Zheng et al.
Pathogen colonization causes tissue damage, chronic inflammation, and antimicrobial resistance, leading to nonhealing wounds. Moreover, bacteria-infected diabetic wounds are particularly difficult to heal owing to persistent hyperglycemia. ...
Injectable and Self-Healing Multifunctional Nanocomposite Hydrogel with an All-in-One Strategy for Efficient Synergistic Photothermal-Sonodynamic-Chemodynamic-Chemotherapy of Pancreatic Cancer [0.03%]
Junhang Li,Jiacheng Li,Weizhong Yuan et al.
Junhang Li et al.
Traditional pancreatic cancer treatment has long been severely hindered by the dense stromal matrix barrier, which drastically impedes the deep penetration of chemotherapy drugs and thus compromises therapeutic efficacy, leading to unsatisf...