Formulation-Driven Control of mRNA Polyplex Physicochemical Properties Enables Spleen-Targeted Systemic Delivery [0.03%]
基于配方的控制使mRNA多聚复合物的理化性质能够实现脾脏靶向全身给药
Mao Hori,Nan Qiao,Kohki Yamada et al.
Mao Hori et al.
Efficient and organ-selective delivery remains a major challenge for messenger RNA (mRNA) therapeutics, motivating extensive material design efforts across diverse delivery systems. Here, we report a simple formulation-based strategy to con...
Munishwar Nath Gupta,Vaishnavi Dubey,Premlata Ambre
Munishwar Nath Gupta
Elastin-like polypeptides (ELPs), synthetic biopolymers inspired by human tropoelastin, have gained considerable attention as versatile nanomaterials for biomedical use due to their inherent biodegradability and tunable molecular architectu...
Electrospun PLGA/PEO Membranes as Antimicrobial Barrier Scaffolds with Sustained Tetracycline Release for Guided Bone Regeneration [0.03%]
载四环素缓释PLGA/PEO电纺膜引导骨再生抗菌支架的作用研究
Thannaphat Jenvoraphot,Krissana Tangamatakul,Pareena Chotjumlong et al.
Thannaphat Jenvoraphot et al.
Guided bone regeneration (GBR) is a standard strategy to promote bone regeneration around dental implants by blocking epithelial and connective tissue invasion into defect sites. Functionalization of barrier membranes with bioactive molecul...
Fe-POM Anchored on mSiO2-Coated Upconversion Nanoparticles for Cascading Catalytic Nano-Synergistic Therapy [0.03%]
基于Fe-POM的UCNPs@mSiO₂纳米载体用于级联催化协同治疗研究
Zhe Yan,Xinyue Liu,Guixin Yang et al.
Zhe Yan et al.
Traditional tumor treatments have limitations, such as poor targeting and systemic toxicity. Therefore, the development of intelligent nanotheranostic systems is necessary. In this work, we developed a multifunctional core-shell nanocomposi...
Degradation-Mediated Bioactive Calcium Release from Alginate Gel Fibers for Enhanced Bone Regeneration [0.03%]
基于藻酸盐凝胶纤维的活性钙离子控制释放促进骨再生修复
Zhangyu Feng,Xueting Yang,Deshuai Jia et al.
Zhangyu Feng et al.
Biodegradable hydrogels are promising for bone regeneration but are limited by a significant mechanical mismatch with bone tissue in modulus, strength, and toughness. To address the weakness, this work reported a mesh-like hydrogel woven fr...
Photocatalytic Depletion of GSH/NADH and O2-Adaptive Pathway Switching in Producing ROS: Overcoming Treatment Resistances of Cancer Cells to Photodynamic Therapy and Inducing Ferroptotic Cell Death [0.03%]
光催化消耗GSH/NADH和O2-适应性途径转换以产生ROS：克服癌细胞对光动力治疗的耐药性并诱导铁死亡
Peiwen Fan,Jianzhi Chen,Jing Liu et al.
Peiwen Fan et al.
Photosensitizers (PSs), capable of overcoming the treatment resistances caused by the elevated levels of glutathione (GSH) and nicotinamide adenine dinucleotide (NADH) within cancer cells as well as the hypoxic microenvironment of solid tum...
Four-Synergy Piezoelectric Microspheres Based on Bone Self-Mineralization for Enhanced Bone Regeneration [0.03%]
一种用于改善骨骼再生的四效压电微球，基于骨自矿化理论
Jiawei Yao,Xiaoyu Zheng,Jingxu Wang et al.
Jiawei Yao et al.
The clinical treatment of irregular bone defects resulting from trauma, tumor resection, and infection remains a significant challenge. To address this issue while enhancing material applicability and bioactivity, this study pioneers the de...
Tailoring Bioink Properties via Nanofibrous Polyelectrolyte Complexes of Distinct Polymeric Classes for Cartilage Tissue Engineering [0.03%]
利用不同聚类纳米纤维状聚电解质复合物调整生物墨水属性用于软骨组织工程
Shreya Chrungoo,Tanmay Bharadwaj,Aishwarya Swain et al.
Shreya Chrungoo et al.
Cartilage is a specialized connective tissue with limited self-regenerative ability, and current cartilage-related trauma treatments often fail to achieve consistent healing. Developing bioinks that closely mimic the native physical, mechan...
Engineered Dual pH/GSH-Responsive Lignin-Based Nanocarriers for Enhanced Tumor Growth Inhibition [0.03%]
一种新型的工程化的基于木质素的纳米载体用于增强抗肿瘤生长抑制作用
Jin Wang,Zhuang Wang,Suyang Dai et al.
Jin Wang et al.
In this study, we designed a lignin-based nanocarrier system with dual-stimuli responsiveness to the acidic pH and elevated glutathione (GSH) levels in the tumor microenvironment, and doxorubicin (DOX) was loaded to develop a nanomedicine d...
Mrinal Kanti Kar,Soumya Srimayee,Biswa Mohan Prusty et al.
Mrinal Kanti Kar et al.
Development of synthetic ion transporters and in situ chemical reaction-mediated communication systems that mimic cellular signaling processes is crucial for preparing protocells to understand complex cellular signaling and related function...