Programmable Peptide Nanofibers Enable Effective MRSA Biofilm Eradication and Infection Control [0.03%]
可编程肽纳米纤维能够有效根除和控制耐甲氧西林金黄色葡萄球菌生物被膜感染
Suchita Paul,Wei-Yu Wang,Yu-Chun Hsiao et al.
Suchita Paul et al.
With antibiotic-resistant bacterial strains rapidly increasing and the development of antibacterial drugs stagnating, alternative solutions are urgently needed. Antimicrobial peptides (AMPs) have emerged as promising therapeutics due to the...
Targeted Disruption of the Outer Membrane of Gram-Negative Bacteria with Enediyne-Labeled Light-Responsive Au Nanorods [0.03%]
携带恩迪亚烷基的光响应金纳米棒靶向破坏革兰氏阴性菌外膜
Joel A Ybe,Mohammad A Mehfooz,Jeffrey M Zaleski
Joel A Ybe
Today a significant number of Gram-negative bacteria have evolved to inactivate traditional antibiotics like penicillin and continue to develop resistance against next-generation antimicrobial drugs at a shocking rate. Taking inspiration fr...
Biodegradable PCL-PLGA Electrospun Nanofibers for Localized Cancer Therapy [0.03%]
用于局部癌症治疗的可降解PCL-PLGA静电纺纳米纤维
Rahul Tiwari,Pranav,Joel Delossantos et al.
Rahul Tiwari et al.
Localized chemotherapy offers a promising strategy to improve therapeutic efficacy while minimizing the systemic toxicity of conventional cancer treatment, particularly following tumor resection. Electrospun nanofibers are well suited for t...
Piperazine-Derived Diamine Lipid Nanoparticles Targeting to the Liver for Delivering Clustered Regularly Interspaced Short Palindromic Repeat Editing of PCSK9 to Durably Maintain Plasmatic Low-Density Lipoprotein Cholesterol in Low Levels [0.03%]
一种肝靶向六氨基哌嗪衍生物递送CRISPR编辑PCSK9的长效低密度脂蛋白胆固醇纳米载体系统
Shifeng Zhao,Shiyun Huang,Nan Li et al.
Shifeng Zhao et al.
Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, and durable suppression of low-density lipoprotein cholesterol (LDL-C) via genome editing represents a promising therapeutic strategy. Here, we report the ...
Dendronized Polymeric Biomaterial for Loading, Stabilization, and Targeted Cytosolic Delivery of microRNA in Cancer Cells [0.03%]
用于负载、稳定及在癌细胞中靶向胞浆递送microRNA的树枝化聚合物生物材料
Vishakha Tambe,Sagarkumar Patel,Amit Shard et al.
Vishakha Tambe et al.
MicroRNAs (miRNAs) are small non-coding RNAs involved in the fine-tuning of gene regulation. Anti-miRNA is a promising RNA-interference (RNAi) agent that potently regulates post-transcriptional expression of an abnormal gene by inhibiting i...
Preparation of a pH-Responsive Janus Composite Fibrous Membrane: an Integrated Performance Study on the Visualized Detoxification of a Mustard Gas Simulant and Treatment of Mustard Gas-Induced Skin Injury [0.03%]
pH响应性Janus复合纤维膜的制备及芥子气模拟剂可视化 detox和糜烂性毒剂所致皮肤损伤治疗的综合性能研究
Yunfan Cheng,Min Zhang,Xin Hu et al.
Yunfan Cheng et al.
Mustard gas (HD) causes ulcerative skin wounds; however, owing to its multiple mechanisms of action, no officially approved specific antidote has been developed to date. Moreover, current therapeutic materials for HD-induced skin injuries g...
Exploring the Link Between Surface Physicochemistry of Cellulose-Based Scaffold and Cellular Activity for Sustainable Tissue Engineering [0.03%]
基于纤维素的组织工程支架材料表面理化性质与细胞行为的关系研究
Beatriz M Herrera,Diego Gomez-Maldonado
Beatriz M Herrera
Several studies have shown functional cell behavior on cellulose-based scaffolds for tissue engineering; however, the link between the cellulose surface physicochemistry and these behaviors is not well identified, reported, or studied. This...
Copper-Based Metal Organic Frameworks for Controlled Curcumin Delivery and Antimicrobial Activity [0.03%]
基于铜的金属有机框架用于控制姜黄素输送及抗菌活动
Md Ashikur Rahman,Na Sun,Mohashin Kabir et al.
Md Ashikur Rahman et al.
Curcumin-loaded HKUST-1, a copper-based metal organic framework, was synthesized and evaluated as a multifunctional platform for biomedical applications. HKUST-1 was prepared via a solvothermal method and used as a carrier for curcumin. Cur...
Biocompatible Zinc-4,4'-bipyridine-Based One-Dimensional Metal-Organic Framework with Unique Structural Features and Antibacterial Potency [0.03%]
一种具有独特结构特性和抗菌活性的一维锌-4,4'-联吡啶基生物相容金属有机骨架材料
Ankita Saha,Bani Preet Kaur,Richa Rani Gupta et al.
Ankita Saha et al.
Increased mortality and escalating healthcare expenses are two major consequences of the ever-growing peril to global health posed by drug-resistant diseases in recent times. To combat these problems, it is crucial to develop suitable bioco...
Hemin-Based Polymer Nanomicelles for Ferroptosis-Mediated Tumor Therapy [0.03%]
基于血红素的聚合物纳米胶束介导的铁死亡抗肿瘤研究
Abu Raihan Sarkar,Anindita Chanda,Nayana Mukherjee et al.
Abu Raihan Sarkar et al.
Ferroptosis is a newly discovered form of cell death mechanism that mostly relies on the elevation of intracellular iron levels for generating excess reactive oxygen species (ROS). It has great potential for therapy of those cancers that ar...