Design and Photophysical Engineering of Functional Organic Luminogens for Precision Cancer Theranostics [0.03%]
用于精准癌症诊疗的功能有机发光材料的设计及光物理调控
Priyam Ghosh,Parameswar Krishnan Iyer
Priyam Ghosh
Cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. Functional organic luminogens have emerged as a versatile class of biomaterials for cancer theranostics, enabling the integration of diag...
Dissolving Amyloid Fibrils with Natural Deep Eutectic Solvents: Citric Acid-Glycerol Achieves Superior Solubilization and Partial Protein Refolding [0.03%]
利用天然超强溶剂溶解淀粉样纤维：柠檬酸-甘油体系具有更优的溶解能力和部分蛋白质复性能力
Sora Hirano,Tatsuya Oshima,Asuka Inada et al.
Sora Hirano et al.
Amyloid protein aggregates pose a significant challenge due to their extreme insolubility and association with neurodegenerative diseases. To identify effective solvents for dissolving amyloid-forming proteins, a screening of deep eutectic ...
Smart Macrocycles: Cyclodextrin-Porphyrin Photosensitizers for Photodynamic Therapy in Human Bladder Cancer Cells [0.03%]
智能大环化合物：用于人类膀胱癌细胞光动力治疗的环糊精-卟啉型光敏剂
Cláudia P S Ribeiro,Rosa Fernandes,Leandro M O Lourenço
Cláudia P S Ribeiro
Urothelial carcinoma of the bladder is one of the most common malignancies of the urinary tract. It remains a therapeutic challenge due to its high recurrence rate and resistance to conventional treatments. Photodynamic therapy (PDT) is an ...
Chair-Shaped Indoline Donor Enabling Near-Infrared Imaging-Guided Type I Photodynamic Therapy [0.03%]
椅式吲哚供体启用近红外成像导向I型光动力疗法
Guofeng Yi,Qiqi Xu,Haodong Liu et al.
Guofeng Yi et al.
Imaging-guided photodynamic therapy (PDT) represents a promising treatment modality owing to its high precision and minimal invasiveness. However, insufficient oxygen supply within solid tumors and aggregation-caused quenching (ACQ) of phot...
Anti-Breast Cancer Effects of Carbon Quantum Dots: In Vivo Angiogenesis and Arginase Co-Inhibition [0.03%]
碳量子点的抗乳腺癌效应：体内协同抑制新生血管和鸟氨酸脱羧酶作用
Gurmeet Singh,Somedutta Maity,Desh Deepak Yadav et al.
Gurmeet Singh et al.
Breast cancer evades the immune system through immune-regulating enzymes. One of them is arginase, primarily produced in tumor-resident cells, especially by tumor-associated macrophages and myeloid-derived suppressor cells. This helps malig...
Triple-Synergistic Therapy with Cobalt-Pheophytin Coordination Micelles for Overcoming Drug Resistance in Pancreatic Cancers [0.03%]
用于克服胰腺癌耐药性的钴原叶绿素配位聚合物胶束的三重协同治疗
Zhen Jiang,Yue Pan,Gengqi Liu et al.
Zhen Jiang et al.
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies as KRAS (Kirsten rat sarcoma viral oncogene homolog) mutations continuously activate multiple downstream signaling pathways, leading to drug resistance. To...
Codelivery of Doxorubicin and Carvacrol via a β-Cyclodextrin-Hyaluronic Acid Nanogel System for Targeted and Stimuli-Responsive Anticancer Therapy [0.03%]
丝裂霉素C和肉桂醛协同抗肿瘤纳米凝胶体系的刺激响应研究
Lakshmi Sathi Devi,Maria Beatrice Morelli,Consuelo Amantini et al.
Lakshmi Sathi Devi et al.
Nanogel systems offer transformative potential in overcoming critical challenges of traditional therapies, such as poor solubility, low bioavailability, and systemic toxicity. In this study, nanogels were developed using thiolated hyaluroni...
Multitargeted Anticancer Strategy through DNA Damage and Mitochondrial Collapse by a Ferrocene-Benzimidazolium Salt [0.03%]
一种通过DNA损伤和线粒体崩溃的多靶点抗癌策略：联苯并咪唑鎓盐的作用机制研究
Nitisha Beniwal,Bikash Lahkar,Girbide Amitkumar Ramakant et al.
Nitisha Beniwal et al.
The development of targeted and selective organometallic anticancer drugs is a primary emphasis in contemporary chemotherapeutic research. We provide the synthesis and thorough biological assessment of a new benzimidazolium-derived ferrocen...
Glucose-Responsive Antibacterial Nanogel for Synergistic Dual-Mode Therapy of Diabetic Wound Infections via Enhancing Cascade Generation of Hydroxyl Radicals and Hypoxia-Induced Activation of Metronidazole [0.03%]
一种协同双模治疗糖尿病感染伤口的葡萄糖响应抗菌纳米凝胶增强羟基自由基级联生成及甲硝唑低氧激活效应
Yinbang Zheng,Weiqing Hu,Yuze Luo et al.
Yinbang Zheng et al.
Pathogen colonization causes tissue damage, chronic inflammation, and antimicrobial resistance, leading to nonhealing wounds. Moreover, bacteria-infected diabetic wounds are particularly difficult to heal owing to persistent hyperglycemia. ...
Injectable and Self-Healing Multifunctional Nanocomposite Hydrogel with an All-in-One Strategy for Efficient Synergistic Photothermal-Sonodynamic-Chemodynamic-Chemotherapy of Pancreatic Cancer [0.03%]
一种用于胰腺癌光热-声动力-化学动力联合治疗的一石四鸟多功能纳米复合水凝胶及其注射和自愈性能研究
Junhang Li,Jiacheng Li,Weizhong Yuan et al.
Junhang Li et al.
Traditional pancreatic cancer treatment has long been severely hindered by the dense stromal matrix barrier, which drastically impedes the deep penetration of chemotherapy drugs and thus compromises therapeutic efficacy, leading to unsatisf...