Richard Nuccitelli
Richard Nuccitelli
Michael Levin
Michael Levin
Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism [0.03%]
钾离子和钠离子通道与瓦堡效应：癌症代谢的生物物理调节机制
Jessica Iorio,Giulia Petroni,Claudia Duranti et al.
Jessica Iorio et al.
Ion channels are progressively emerging as a novel class of membrane proteins expressed in several types of human cancers and regulating the different aspects of cancer cell behavior. The metabolism of cancer cells, usually composed by a va...
Antibodies Targeting KV Potassium Channels: A Promising Treatment for Cancer [0.03%]
针对KV钾通道的抗体：癌症治疗的新希望
Ileana Hernandez-Resendiz,Franziska Hartung,Luis A Pardo
Ileana Hernandez-Resendiz
Voltage-gated potassium channels are transmembrane proteins that allow flow of potassium across the membrane to regulate ion homeostasis, cell proliferation, migration, cell volume, and specific processes such as muscular contraction. Aberr...
Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment [0.03%]
细胞外钾抑制T细胞功能：肿瘤微环境中免疫抑制的含义
Seow Theng Ong,Aik Seng Ng,Xuan Rui Ng et al.
Seow Theng Ong et al.
Background: Dying tumor cells release intracellular potassium (K+), raising extracellular K+ ([K+]e) in the tumor microenvironment (TME) to 40-50 mM (high-[K+]e). Here, we investigated the effect of high-[K+]e on T cell functions. Materials...
Effect of Sigma-1 Receptors on Voltage-Gated Sodium Ion Channels in Colon Cancer Cell Line SW620 [0.03%]
Sigma-1受体对结肠癌细胞系SW620电压门控钠离子通道的作用研究
Ebru Aydar,Christopher Palmer
Ebru Aydar
Background: Voltage-gated sodium channels (VGSCs) play pivotal roles in the metastatic process in several cancers, including breast and colon cancers. Sigma-1 receptors are known to interact and form complexes with a number of ion channels ...
Cationic Modulation of Voltage-Gated Sodium Channel (Nav1.5): Neonatal Versus Adult Splice Variants-2. Divalent (Cd2+) and Trivalent (Gd3+) Ions [0.03%]
电压门控钠通道（Nav1.5）阳离子调节：新生儿与成人剪接变异型-2. 二价（Cd2+）和三价（Gd3+）离子
Rustem Onkal,Scott P Fraser,Mustafa B A Djamgoz
Rustem Onkal
Background: A "neonatal" splice-form of the voltage-gated sodium channel Nav1.5 is functionally expressed in human cancers and potentiates metastatic cell behaviors. Splicing causes the replacement of 7 amino acids, including a negatively c...
Cationic Modulation of Voltage-Gated Sodium Channel (Nav1.5): Neonatal Versus Adult Splice Variants-1. Monovalent (H+) Ions [0.03%]
电压门控钠通道(Nav1.5)的阳离子调节：新生儿与成人剪接变异体-1. 单价(H+)离子
Rustem Onkal,Scott P Fraser,Mustafa B A Djamgoz
Rustem Onkal
Background: Voltage-gated sodium channels are functionally expressed in human carcinomas. In breast and colon cancers, the neonatal splice variant of Nav1.5 (nNav1.5) is dominant. This differs from the adult (aNav1.5) by several amino acids...
Ultrasensitive System for Electrophysiology of Cancer Cell Populations: A Review [0.03%]
癌症细胞群体电生理的超灵敏系统：综述
Paulo R F Rocha,Aya Elghajiji,David Tosh
Paulo R F Rocha
Bioelectricity is the electrical activity produced by living organisms. Understanding the role of bioelectricity in a disease context is important as it contributes to both disease diagnosis and therapeutic intervention. Electrophysiology t...
Bioelectricity of Cancer [0.03%]
癌症生物电学
Mustafa B A Djamgoz,Annarosa Arcangeli
Mustafa B A Djamgoz