Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment
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Background: Dying tumor cells release intracellular potassium (K+), raising extracellular K+ ([K+]e) in the tumor microenvironment (TME) to 40-50 mM (high-[K+]e). Here, we investigated the effect of high-[K+]e on T cell functions. Materials and Methods: Functi... ...
