Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment [0.03%]
细胞外钾抑制T细胞功能：肿瘤微环境中免疫抑制的含义
Seow Theng Ong,Aik Seng Ng,Xuan Rui Ng et al.
Seow Theng Ong et al.
Background: Dying tumor cells release intracellular potassium (K+), raising extracellular K+ ([K+]e) in the tumor microenvironment (TME) to 40-50 mM (high-[K+]e). Here, we investigated the effect of high-[K+]e on T cell functions. Materials...
Effect of Sigma-1 Receptors on Voltage-Gated Sodium Ion Channels in Colon Cancer Cell Line SW620 [0.03%]
Sigma-1受体对结肠癌细胞系SW620电压门控钠离子通道的作用研究
Ebru Aydar,Christopher Palmer
Ebru Aydar
Background: Voltage-gated sodium channels (VGSCs) play pivotal roles in the metastatic process in several cancers, including breast and colon cancers. Sigma-1 receptors are known to interact and form complexes with a number of ion channels ...
Cationic Modulation of Voltage-Gated Sodium Channel (Nav1.5): Neonatal Versus Adult Splice Variants-2. Divalent (Cd2+) and Trivalent (Gd3+) Ions [0.03%]
电压门控钠通道（Nav1.5）阳离子调节：新生儿与成人剪接变异型-2. 二价（Cd2+）和三价（Gd3+）离子
Rustem Onkal,Scott P Fraser,Mustafa B A Djamgoz
Rustem Onkal
Background: A "neonatal" splice-form of the voltage-gated sodium channel Nav1.5 is functionally expressed in human cancers and potentiates metastatic cell behaviors. Splicing causes the replacement of 7 amino acids, including a negatively c...
Cationic Modulation of Voltage-Gated Sodium Channel (Nav1.5): Neonatal Versus Adult Splice Variants-1. Monovalent (H+) Ions [0.03%]
电压门控钠通道(Nav1.5)的阳离子调节：新生儿与成人剪接变异体-1. 单价(H+)离子
Rustem Onkal,Scott P Fraser,Mustafa B A Djamgoz
Rustem Onkal
Background: Voltage-gated sodium channels are functionally expressed in human carcinomas. In breast and colon cancers, the neonatal splice variant of Nav1.5 (nNav1.5) is dominant. This differs from the adult (aNav1.5) by several amino acids...
Ultrasensitive System for Electrophysiology of Cancer Cell Populations: A Review [0.03%]
癌症细胞群体电生理的超灵敏系统：综述
Paulo R F Rocha,Aya Elghajiji,David Tosh
Paulo R F Rocha
Bioelectricity is the electrical activity produced by living organisms. Understanding the role of bioelectricity in a disease context is important as it contributes to both disease diagnosis and therapeutic intervention. Electrophysiology t...
Bioelectricity of Cancer [0.03%]
癌症生物电学
Mustafa B A Djamgoz,Annarosa Arcangeli
Mustafa B A Djamgoz
Potential Clinical Applications and Future Prospect of Wireless and Mobile Electroencephalography on the Assessment of Cognitive Impairment [0.03%]
无线和移动脑电图在认知障碍评估中的潜在临床应用及未来展望
Fangzhou Li,Naohiro Egawa,Shusuke Yoshimoto et al.
Fangzhou Li et al.
Electroencephalography (EEG) systems have been used for assessing cognitive function in dementia for several decades. Studies have demonstrated that EEG in Alzheimer's disease (AD) patients is generally characterized by significant and spec...
Measuring Changes in Electrical Impedance During Cell-Mediated Mineralization [0.03%]
细胞介导矿化过程中电气阻抗的变化测量
Rafael Ramos,Kairui Zhang,David Quinn et al.
Rafael Ramos et al.
Background: The fundamental electrical properties of bone have been attributed to the organic collagen and the inorganic mineral component; however, contributions of individual components within bone tissue toward the measured electrical pr...
Sophie Rose,Marc Rogers
Sophie Rose
A summary of the presentations featured at two key ion channel-focused events. This includes the Ion Channels in Drug Discovery XIX Satellite Meeting held at the 63rd Annual Meeting of the Biophysical Society (2019) and the Cambridge Ion Ch...
Executive Editor's Picks [0.03%]
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Michael Levin
Michael Levin