Zebrafish and CRISPR-A synergistic approach to decipher and cure human diseases [0.03%]
斑马鱼和CRISPR-A协同方法破解并治愈人类疾病
Manikandan Sivaprakasam,Aashika Raagavi Jeanpierre,Salma Mohammed et al.
Manikandan Sivaprakasam et al.
Rapidly emerging infectious and genetic diseases demand robust vertebrate models to investigate pathogenesis and accelerate therapeutic discovery. Zebrafish (Danio rerio) offer substantial translational value owing to their conserved physio...
Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1-mediated P53 ubiquitination [0.03%]
皮肤乳头层Gorab缺乏促进衰老并与RCHY1介导的P53泛素化失调有关
Yanhong Li,Wei Liang,Yanfeng Xu et al.
Yanhong Li et al.
Background: Mutations in and functional inactivation of the Gorab gene cause gerodermia osteodysplastica (GO), a disease featuring wrinkled skin and osteoporosis, but the underlying mechanisms of skin aging remain incompl...
Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection [0.03%]
叙利亚仓鼠、C57BL / 6和BALB /小鼠中.BL小鼠的选择前临床模型的比较病毒学和病理学：六和BALB /小鼠中的猴痘病毒病理学
Xiaohui Wei,Jing Wu,Hekai Yang et al.
Xiaohui Wei et al.
Monkeypox virus (MPXV), a zoonotic orthopoxvirus, has emerged as a major public health concern following its global spread in 2022. Robust small animal models are urgently needed to investigate MPXV pathogenesis and evaluate medical counter...
An ultra-processed food-based cafeteria diet induces obesity, metabolic dysfunction, and tissue-specific gene dysregulation in C57BL/6 mice [0.03%]
以高度加工食品为主的食堂膳食可诱导C57BL/6小鼠肥胖、代谢紊乱及组织特异性基因表达异常
Guilherme Coutinho Kullmann Duarte,Daisy Crispim,Shiva Cerutti Wittée et al.
Guilherme Coutinho Kullmann Duarte et al.
Background: The cafeteria diet (CAFD) model has been used to mimic the Western-style "junk food" eating pattern, inducing obesity in rodents. As the dietary composition varies across studies, we developed a CAFD model bas...
A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster [0.03%]
仓鼠九种器官的蛋白质组和磷酸化蛋白质组图谱
Luyao Zhang,Tao Ding,Wanjun Peng et al.
Luyao Zhang et al.
Background: The Chinese hamster (Cricetulus griseus) is not only an important model organism but also the source of Chinese hamster ovary cells, which play an indispensable role in biomedical and biopharmaceutical researc...
Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence [0.03%]
二甲双胍通过激活AMPK改善压力性尿失禁模型大鼠外尿道括约肌完整性及恢复控尿功能
Yuting Xu,Xuhong Li,Alvaro Munoz et al.
Yuting Xu et al.
Background: Stress urinary incontinence (SUI) is primarily caused by structural and functional damage to the external urethral sphincter (EUS). In previous studies, metformin, a known AMP-activated protein kinase (AMPK) a...
The characteristics of collagen-induced rheumatoid arthritis in macaques and the changes of heart [0.03%]
猕猴胶原诱导的类风湿关节炎的特点及心脏病变的变化特征
Lei Zhang,Haifeng Jiang,Zhen Xu et al.
Lei Zhang et al.
Background: Based on human Rheumatoid Arthritis (RA) criteria, this study established a macaque collagen-induced arthritis (CIA) model and a standardized non-human primate (NHP) standardized diagnostic framework. Integrat...
Equine models in translational medicine: A comparative approach to human health [0.03%]
马在转化医学中的模型作用：对人体健康进行比较研究的方法论
Shayan Boozarjomehri Amnieh,Katarzyna Ropka-Molik
Shayan Boozarjomehri Amnieh
The horse is a distinctive translational model for bridging mechanistic discovery and clinically relevant investigation because of its physiological complexity, long lifespan, athletic phenotype, and broad spectrum of naturally occurring co...
A preclinical mouse model mimicking the ovarian cancer-induced estrogen deficiency-depression axis [0.03%]
模拟卵巢癌诱导的雌激素缺乏-抑郁轴的临床前小鼠模型
Jiamin Liu,Yafei Yang,Chunxi Liu et al.
Jiamin Liu et al.
Background: Young ovarian cancer (OC) patients often experience a synergistic interplay among tumor progression, estrogen deficiency, and depression, which severely compromises prognosis and quality of life. However, a pr...
Yong-Jian Zhu,Lin-Chao Zhou,Xiao-Xue Zhang et al.
Yong-Jian Zhu et al.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, yet life-threatening disorder characterized by persistent pulmonary vascular obstruction and elevated pulmonary artery pressure, with progressive remodeling and subsequent rig...