Jian Li,Pei-Yu Jiang,Hui Zhao et al.
Jian Li et al.
Hepatitis A virus (HAV) is an important pathogen that has continuously posed a threat to global public health for over 5000 years. The development of accessible and reliable small animal models, especially murine models, is essential for el...
Stem cell-based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection [0.03%]
Zifan Li,Yu Kang,Yuyu Niu
Zifan Li
Transplantation of insulin-producing cells derived from pluripotent stem cells represents a highly promising approach for the radical treatment of type 1 diabetes (T1D). Informed by a comprehensive understanding of fetal pancreatic developm...
Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts [0.03%]
Thansita Bhunyakarnjanarat,Chatsuree Suksamai,Dhammika Leshan Wannigama et al.
Thansita Bhunyakarnjanarat et al.
Background: Gut barrier integrity prevents microbial translocation and systemic infection. Chronic alcohol disrupts this barrier, but its role in infection susceptibility among immune-compromised hosts remains unclear. We...
Zihang Guo,Ling Zhang,Shoulong Deng et al.
Zihang Guo et al.
The escalating global incidence of end-stage renal disease has exacerbated the critical shortage of kidneys from human donors. Porcine kidney xenotransplantation has emerged as the most promising alternative solution to providing an unlimit...
Nicolas Skuli,Rudra B Amin,A&#x;ishah Bakayoko et al.
Nicolas Skuli et al.
Human or humanized immune system (HIS) animal models have emerged as indispensable tools for studying human biology and disease in vivo. By engrafting human hematopoietic and hematopoietic stem cells (HSC) into immunodeficient hosts, these ...
Multi-omics data mining combined with experimental validation reveals ferroptosis- and autophagy-associated hub genes as diagnostic candidates and immune modulators in atherosclerosis [0.03%]
Xinou Zheng,Jinling Zheng,Xuezhuang Li et al.
Xinou Zheng et al.
Background: Atherosclerosis (AS) is a chronic inflammatory vascular disease that can lead to severe cardiovascular events. Ferroptosis and autophagy have been increasingly recognized for their significant roles in AS; how...
SDPR-STK38 axis controls the proliferation-differentiation balance in alveolar type II cells [0.03%]
SDPR-STK38轴调控肺泡Ⅱ型细胞增殖分化平衡
Jie Wang,Xuepei Lei,Yiying Huang et al.
Jie Wang et al.
Background: Alveolar type II (AT2) cells act as progenitors that sustain gas exchange and drive postinjury repair. Disruption of their proliferation-differentiation balance promotes pulmonary fibrosis and acute respirator...
A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions [0.03%]
一种新的复发性出血微环境小鼠子宫内膜异位症模型
Yu Zhuang,Yan Zan,Tiantian Ma et al.
Yu Zhuang et al.
Current models of endometriosis (EMs) still have limitations in replicating the key pathological features of human EMs, particularly the cyclic bleeding associated with ectopic lesions. To address this gap, this study aimed to develop a pro...
A microscopically assisted limited colectomy mouse model of early colon cancer [0.03%]
一种早期结肠癌的显微镜辅助有限结肠切除术小鼠模型
Yu Han,Yixin Zhang,Dazhi Gao et al.
Yu Han et al.
Background: Currently, there is a lack of an adequate rodent model for investigating surgical techniques and comprehensive treatment options for patients with colorectal cancer (CRC). This study presents a mouse model tha...
USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre-mRNA splicing [0.03%]
USB1缺陷通过干扰RNA调节独立于预信使RNA剪接紊乱中性粒细胞成熟
Hang Li,Guiying Shi,Jiaming Tang et al.
Hang Li et al.
Background: U6 biogenesis 1 (USB1) gene mutations cause poikiloderma with neutropenia (PN), which is clinically characterized by skin hyperpigmentation, nail dysplasia, neutropenia, and an elevated risk of cancer. USB1 fu...