The diagnostic value of the circadian rhythm gene KLF10 in anxiety-depressive disorders and its neuroimmune regulatory mechanisms [0.03%]
昼夜节律基因KLF10在抑郁焦虑障碍的诊断价值及神经免疫调控机制研究
Anlan Liu,Weifeng Guo,Jianxiang Li et al.
Anlan Liu et al.
Background: Anxiety-depressive disorder (ADD) is one of the important subtypes of depression, which has been shown to be closely related to neuroimmune abnormalities. Currently, specific biomarkers have not been identifie...
SnRNA-seq reveals cellular heterogeneity and proliferation mechanisms in limb venous malformations [0.03%]
利用snRNA-seq揭示肢体静脉畸形的细胞异质性和增殖机制
Junjie Lin,Tingting Liu,Bin Fang et al.
Junjie Lin et al.
Background: Venous malformations (VMs) are congenital vascular anomalies characterized by abnormal vascular proliferation, with limb VMs often leading to functional impairment and physical discomfort. However, the cellula...
Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post-traumatic stress disorder [0.03%]
芸香素通过多通路调节单次长时间应激致 PTSD 大鼠模型神经炎症及氧化应激作用机制研究
Godson Emeka Anyanwu,Ogan Christopher Akanaku,Augustine Oviosun et al.
Godson Emeka Anyanwu et al.
Background: Post-traumatic stress disorder (PTSD) is a complicated neuropsychiatric disorder that is marked by long-term neuroinflammation, oxidative stress, and poor neuroplasticity in stress-sensitive brain areas. Hespe...
Ac-SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes [0.03%]
Ac-SDKP通过HSP27及FAS/FASL和线粒体轴调控凋亡作用
Wenxin Guo,Jinyin Yan,Wenli Li et al.
Wenxin Guo et al.
Background: Silicosis is a progressive, irreversible fibrotic lung disease caused by long-term exposure to crystalline silica. Although the anti-fibrotic tetrapeptide Ac-SDKP has shown promise in reducing fibrosis, the sp...
Sappanwood extract modulates hepatic structure-function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia [0.03%]
苏木提取物对苯肼致溶血性贫铁诱导的肝脾肿大及相关铁调节通路的影响研究
Mohammad Indra Pratama,Ratu Safitri,Desak Made Malini et al.
Mohammad Indra Pratama et al.
Background: Hepatomegaly in hemolytic disorders, including in thalassemia, is a common complication, primarily due to hemosiderosis and activation of extramedullary hematopoiesis. Globin chain imbalance leads to chronic h...
The potency of native postbiotics and paraprobiotics in modulating inflammation by affecting the gut-kidney axis [0.03%]
内源性后生元和类生元通过影响肠-肾轴调节炎症的作用力
Fatemeh Haririzadeh Jouriani,Mahnaz Torfeh,Fatemeh Ashrafian et al.
Fatemeh Haririzadeh Jouriani et al.
Background: The gut's impact on kidney health can be observed through its influence on the gut-kidney axis. However, using paraprobiotic and postbiotic agents may improve gut health and kidney function by affecting signal...
Yaru Niu,Xu Guan,Jian Ma et al.
Yaru Niu et al.
Background: Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and tissue injury. Fibroblastic reticular cells (FRCs) play a critical role in maintaining LN ...
Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches [0.03%]
糖尿病动物模型的构建方法及研究进展
Milad Faraji,Maedeh Faraji,Nasrin Kazemipour
Milad Faraji
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. It involves complex metabolic, hormonal, and immunological mechanisms that cannot be fully reprod...
Refining a preclinical model of viral myocarditis in accordance with biotech standards [0.03%]
根据生物技术标准完善病毒性心肌炎临床前模型的研究
Jonas Stewen,Julia Riedesel,Juliane Stein et al.
Jonas Stewen et al.
Background: Viral myocarditis is a clinically relevant inflammatory heart disease that can progress to dilated cardiomyopathy and heart failure. However, preclinical models often suffer from limited translational relevanc...
A modified D-galactose-induced aging rat model with low-dose intraperitoneal ozone: Redox, functional, and skin outcomes [0.03%]
改良的D-半乳糖诱导的大鼠衰老模型：低剂量腹腔注射臭氧的氧化还原、功能和皮肤结果
Isabella Kurnia Liem,Raisa Nauli,Firda Asma&#x;ul Husna et al.
Isabella Kurnia Liem et al.
Aging impairs quality of life, making experimental models essential to evaluate interventions that modulate age-related changes. This study aimed to characterize a modified D-galactose-induced aging model and explore the effects of intermit...