Ferroptosis: A Key Mechanism in Alcohol-Induced Mitochondrial Dysfunction and Oxidative Stress [0.03%]
铁死亡：酒精诱导的线粒体功能障碍和氧化应激的关键机制
Gouthami Kuruvalli,Nagajyothi Chidanandha Patnamsetty,Padmavathi Pannuru et al.
Gouthami Kuruvalli et al.
Alcoholic liver disease (ALD) is a complex condition marked by mitochondrial dysfunction, oxidative stress, and hepatocellular death. Among the various mechanisms involved, ferroptosis, a regulated form of cell death driven by iron-dependen...
Influence of Chagas Disease on the Pharmacokinetics of Benznidazole in the Dog Model [0.03%]
利什曼病对狗体内苯硝唑药代动力学影响的研究
Lorena Cera Bandeira,Leonardo Pinto,Fernanda de Lima Moreira et al.
Lorena Cera Bandeira et al.
The high variability in efficacy and safety of antichagasic chemotherapy involving benznidazole (BNZ) may be due to pharmacokinetic-related factors. The study evaluated the impact of experimental acute and chronic infections by the Berenice...
Differential Effects of Acute and Chronic Fluoxetine on Psychedelic-Induced Behavior in Mice: Implications for Clinical Trials [0.03%]
急性氟西汀和慢性氟西汀对小鼠致幻剂诱导行为的差异影响及其临床意义
Bo Jarrett Wood,M Frances Vest,Catharine Carfagno et al.
Bo Jarrett Wood et al.
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for mood and anxiety disorders, the same conditions under which psychedelic-assisted therapies are gaining renewed interest. However, it remains unclear how SSRI treatmen...
Impact of Side Chain Structure and Aglycon Carbonyl Group on the Immunostimulatory Activities of Semisynthetic Saponin Adjuvants [0.03%]
侧链结构和配糖体羰基基团对半合成皂苷佐剂免疫刺激活性的影响
Di Bai,Liz Wang,Rebekah Beyea et al.
Di Bai et al.
VSA-1 and VSA-2 are recently developed semisynthetic saponin immunostimulants derived from natural Momordica saponins (MS) I and II, respectively, through the incorporation of a linear dodecyl or benzyl undecanoate side chain. In this study...
Mavacamten Derivatives Significantly Ameliorate Lipopolysaccharide-Induced Acute Lung Injury, Partly by Modulating Nuclear Factor Kappa‑B Signaling [0.03%]
马瓦卡木亭衍生物通过调节核因子κB信号显著改善脂多糖诱导的急性肺损伤
Anjali Veeram,Rahul Shingare,Nithya Sree Pr et al.
Anjali Veeram et al.
Acute lung injury (ALI) and Acute respiratory distress syndrome (ARDS) are critical pulmonary disorders marked by excessive inflammation and cytokine storm, often resulting in respiratory failure and high mortality, especially if untreated....
Cytochrome P450 2D6 (CYP2D6) Inhibition by Bergamottin and Diosmetin as a Strategy to Enhance the Pharmacokinetics and Antidepressant Efficacy of Amoxapine [0.03%]
bergaptene和diosmetin通过抑制细胞色素P450 2D6来增强阿莫沙平的药代动力学及抗抑郁作用：一种药物相互作用策略
Sachin Dattram Pawar,Shreyash Santosh Yadav,Sai Sharanya Pulimamidi et al.
Sachin Dattram Pawar et al.
Amoxapine (AMX) is an FDA-approved tricyclic antidepressant used to treat major depressive disorders by modulating monoaminergic neurotransmitters, including serotonin, dopamine, and noradrenaline. However, its clinical efficacy is limited ...
The Future of Epigenetics: Emerging Technologies and Clinical Applications [0.03%]
表观遗传学的未来：新兴技术及临床应用
Kavita A Iyer,Rumiana Koynova-Tenchov,Janet M Sasso et al.
Kavita A Iyer et al.
Epigenetics, the study of heritable changes in gene expression that do not involve alterations to the DNA sequence, has emerged as a transformative field in biology and medicine, revealing how gene expression is modulated in response to int...
Effect of a Negatively Charged Amino Acid Linker on the Tumor-Targeting Properties of [177Lu]Lu-Labeled 4‑ p‑(Tolyl)butyric Acid-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides [0.03%]
含负电荷氨基酸连接子对[177Lu]Lu-DOTA-Gln-Bmt1-Ammecamitide和[177Lu]Lu-DOTA-Mpa-Gln1-Amcamitide抗肿瘤特性的影响
Zheng Qiao,Jingli Xu,Fabio Gallazzi et al.
Zheng Qiao et al.
This study aimed to examine how negatively charged amino acid linkers influence the tumor-targeting and biodistribution properties of [177Lu]-Lu-labeled 4-p-(tolyl)-butyric acid (p-TBA)-conjugated alpha-melanocyte-stimulating hormone peptid...
96-Well Format-Based Liver-Heart-on-a-Chip Platform for Facile and Parallel Testing of Drug-Induced Cardiotoxicity after Liver Metabolism [0.03%]
一种基于96孔板的肝心芯片平台用于检测经肝脏代谢后药物引起的心脏毒性的简便且并行测试
Sebeen Lee,Chaewon Jin,Hongsoo Choi et al.
Sebeen Lee et al.
Current preclinical drug evaluation predominantly relies on conventional two-dimensional (2D) cell cultures grown in static environments, which lack dynamic interactions and fail to recapitulate complex microenvironments. These approaches a...
Revolutionizing Sun Protection: Emerging Nanotechnologies Shaping the Future of Sunscreens [0.03%]
重塑防晒未来：新兴纳米技术引领 sunscreen革命
Millena de S Afonso,Pamella M de Souza,Adriany L Dos Santos et al.
Millena de S Afonso et al.
Sun protection has become a significant public health issue in recent decades due to the high incidence of skin diseases related to excessive exposure to ultraviolet (UV) rays. The use of nanosystems in sunscreens represents a promising inn...