Boldine Mitigates Chronic Unpredictable Stress-Induced Depression by Suppressing Serotonin 3A Receptor-Calcium/Calmodulin-Dependent Protein Kinase II Signaling and Nucleotide-Binding Domain Leucine-Rich Repeat Protein 3 Inflammasome in the Hippocampus [0.03%]
Boldine通过抑制五羟色胺3A受体-钙/钙调蛋白依赖型蛋白激酶II信号传导和核苷酸结合域富含亮氨酸重复蛋白3炎性小体减轻海马区慢性不可预测压力诱导的抑郁作用
Likhit Akotkar,Urmila Aswar
Likhit Akotkar
Major depressive disorder is a debilitating condition linked to dysregulated serotonin (5-HT) signaling, neuroinflammation, and oxidative stress. Boldine (BDN), a natural aporphine alkaloid with antioxidant and neuroprotective properties, m...
A Paradigm Shift in Snakebite Envenoming Therapy: From Conventional Antivenoms to Rationally Designed, Broadly Neutralizing Combination Therapies [0.03%]
蛇咬中毒治疗范式的转变：从传统抗蛇毒血清到理性设计的广谱中和联合疗法
Ning Shi,Jie Wang,Can Xu et al.
Ning Shi et al.
For over a century, polyclonal antivenom has been the cornerstone of snakebite therapy, saving countless lives. However, the current production method, based on immunizing large animals, has inherent limitations in terms of safety, stabilit...
Chimeric Antigen Receptor T‑Cell Therapy Targeting Tumor Necrosis Factor Receptor Superfamily Member 8 (CD30) for Relapsed or Refractory Anaplastic Large Cell Lymphoma: Rationale, Strategies, and Emerging Clinical Evidence [0.03%]
针对靶向肿瘤坏死因子受体超家族成员8（CD153/CD30）的嵌合抗原受体T细胞疗法治疗复发或难治性间变性大细胞淋巴瘤：理论依据、策略和新兴临床证据
Alberto Boretti
Alberto Boretti
Chimeric Antigen Receptor (CAR) T-cell therapy has fundamentally altered the treatment paradigm for relapsed or refractory (R/R) B-cell malignancies. However, translating this success to T-cell lymphomas has been impeded by a critical biolo...
Translational Geroscience Strategies for Delaying Multimorbidity [0.03%]
translation-geroscience延迟多发病的转化衰老科学研究策略
Pukar Khanal,Jagdish Chand,Vishal S Patil et al.
Pukar Khanal et al.
The global rise in aging populations emphasizes an urgency to mitigate the escalating burden of chronic age-related diseases. This review discusses advances in geroscience to reframe aging as a modifiable risk factor rather than an inevitab...
Evolving Treatments and Resistance Mechanisms in Prostate Cancer Therapeutics [0.03%]
前列腺癌治疗中的演变、耐药机制
Gali Sri Venkata Sai Rishma Reddy,Anuj Kumar,Neeraj Kumar Sharma et al.
Gali Sri Venkata Sai Rishma Reddy et al.
Prostate cancer remains a leading cause of cancer-related morbidity and mortality among men, fundamentally driven by gain-of-function alterations in the androgen receptor (AR) signaling axis. Although major therapeutic advances from androge...
Cathepsin Inhibitor Suppresses the Growth of Ectopic Hepatocellular Carcinoma Tumors in Mouse Models [0.03%]
猫森肽酶抑制剂可抑制小鼠异位肝癌肿瘤生长
Olamide Crown,Oluwatoyin V Odubanjo,Olawale S Adeyinka et al.
Olamide Crown et al.
The advanced stages of hepatocellular carcinoma (HCC) are challenging to treat because of the invasion of blood vessels by malignant cells, as well as underlying cirrhosis in most patients. Current chemotherapeutic approaches are hindered b...
Comparing Heparin and Heparin Mimetics in Targeting Immunomodulatory Proteins from Platelets to Activate T Cell-Dependent Immune Response in Oncology [0.03%]
比较肝素和肝素模拟物在靶向血小板免疫调节蛋白以激活肿瘤学中T细胞依赖性免疫反应方面的效果
Katrin Nekipelov,Sven Otto,Maximilian Henseler et al.
Katrin Nekipelov et al.
Platelets play a crucial role in the hematogenous metastasis of cancer. Beyond their mechanical function of forming a protective cloak around circulating tumor cells, which can be antagonized by heparin, activated platelets release various ...
A Holistic Approach to Identifying a Positron Emission Tomography (PET) Tracer Candidate for In Vivo Imaging of Purinergic P2X7 Receptor in Neuroinflammation [0.03%]
一种用于体内神经炎症中核糖核酸P2X7受体放射性正电子发射断层成像示踪剂的综合鉴定方法
Imane Ghafir El Idrissi,Andrea Spinaci,Daniele Vitone et al.
Imane Ghafir El Idrissi et al.
The central role of neuroinflammation in the pathogenesis of neurodegenerative diseases and brain disorders has spurred the development of Positron Emission Tomography (PET) radiotracers to investigate neuroimmune mechanisms noninvasively i...
Therapeutic Potential of 1‑(1,2,3,5,6,7-Hexahydro‑ s‑indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea (MCC950), a Potent Agent for Improving Autoinflammatory Hearing Loss in Mice with Myeloid Cell-Specific Conditional Expression of Mutant Nucleotide-Binding Oligomerization Domain, Leucine-Rich Repeat, and Pyrin Domain-Containing Protein [0.03%]
1-(1,2,3,5,6,7-己氢-s-吲哚并[a]环庚烷-4-基)-3-[4-(2-羟基丙基)呋喃-2-基]磺酰脲(MCC950)改善髓系细胞条件性表达突变NOD-like受体蛋白3小鼠自身炎症性听力损失的潜力研究
Ngoc-Trinh Tran,Bong Jik Kim,Minyoung Kim et al.
Ngoc-Trinh Tran et al.
Autoinflammatory hearing loss due to NLRP3 inflammasome activation is poorly understood. We developed a novel myeloid-specific Nlrp3 mutant mouse model (Nlrp3 D301NneoR/+; LysM Cre/+) expressing the D301N Nlrp3 variant in macrophages and ne...
Mechanisms and Design Principles of Proteolysis-Targeting Chimeras and Their Emerging Applications [0.03%]
蛋白酶体靶向嵌合体的机制、设计原理及其新兴应用
Nikola Knoll,Nouri Neamati,Aykut Üren
Nikola Knoll
The ubiquitin-proteasome system (UPS) comprises an important cellular process that regulates protein homeostasis by selectively degrading misfolded or damaged proteins, as well as those with short half-lives. Proteins are targeted for prote...