Synthesis, Biological Evaluation, and Computational Study of Pyridine- and Indazole-Based Inhibitors of the Inducible Nitric Oxide Synthase as Promising Antipsoriatic Agents [0.03%]
具有抗银屑病作用的诱导型一氧化氮合酶(pyridine-和indazole-基于抑制剂)的合成，生物评价及计算研究
Pasquale Amoia,Marialucia Gallorini,Claudia Scarponi et al.
Pasquale Amoia et al.
The dysregulation of inducible nitric oxide synthase (iNOS) is linked to various diseases, including psoriasis, where it contributes to imbalanced nitro-oxidative stress. iNOS is primarily produced in the skin's epidermal layer and can be a...
Roles of RNA-Binding Nuclear Proteins in Alzheimer's Disease Pathophysiology [0.03%]
阿尔茨海默病病理生理过程中RNA结合核蛋白的作用
Sandeep Kumar,Arun Upadhyay
Sandeep Kumar
Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive decline. Pathologically, AD is characterized by the accumulation of amyloid β (Aβ) monomers that may generate oligomers or fibrils in the extracellular spa...
Bemarituzumab Suppresses Choroidal Neovascularization in Mice by Downregulating Melanoma Cell Adhesion Molecule and Yes-Associated Protein 1 [0.03%]
贝马珠单抗通过下调黑色素瘤细胞黏附分子和Yes相关蛋白1抑制小鼠脉络膜新生血管形成
Liujun Ding,Bintao Xie,Jineng Lv et al.
Liujun Ding et al.
In recent years, some fibroblast growth factors (FGFs) have been reported to be promising therapeutic targets for neovascular age-related macular degeneration (nAMD). Interestingly, we found that the FGFR2b inhibitor bemarituzumab (FPA144) ...
A Trypanothione Synthetase-Based Subunit Vaccine Induces Protective Th1 Immunity against Visceral Leishmaniasis in Mice [0.03%]
基于锥虫硫醇酯合成酶的子疫苗诱导小鼠内脏利什曼病的保护性Th1免疫反应
Ehasanullah Khan,Atreyee Chatterjee,Shiv Kumar et al.
Ehasanullah Khan et al.
Leishmaniasis, caused by Leishmania species, remains a major global health challenge due to limited therapeutic options, drug resistance, and relapse. To achieve long-term protection, an effective vaccine is urgently needed. In this work, w...
Dapagliflozin Protects Cardiomyocytes against Doxorubicin-Induced Toxicity by Modulating Sirtuin 1/Sirtuin 3 and Ferroptosis Pathway [0.03%]
达格列净通过调节Sirtuin 1/Sirtuin 3及铁死亡信号通路保护多柔比星致心肌细胞毒性作用
Hnin Ei Ei Khine,Supachoke Mangmool,Warisara Parichatikanond
Hnin Ei Ei Khine
Cardiac dysfunction can be aggravated by chemotherapeutic agents, including doxorubicin, through mechanisms involving mitochondrial dysfunction, elevated oxidative stress, suppression of sirtuin (SIRT1/SIRT3) signaling, and activation of ap...
Lentiviral-Mediated Expression of a Novel Transforming Growth Factor‑β (TGF-β) Inhibitor Peptibody Therapeutically Mitigates Established Liver Fibrosis by Modulating Inflammation and Inducing Metabolic Reprogramming [0.03%]
lentivirus表达新型转化生长因子-β抑制剂peptibody治疗 Established liver fibrosis通过调节炎症和诱导代谢重编程）
Anabela La Colla,Carolina Anahí Cámara,Tania Melina Rodríguez et al.
Anabela La Colla et al.
Chronic liver diseases are characterized by an excessive wound-healing response that leads to liver fibrosis. Effective antifibrotic therapies capable of reversing established fibrosis remain an unmet clinical need. TGF-β signaling is enha...
Mapping the Brain Interaction Network of the Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Targeted by Leucettinib-21 Using Affinity Chromatography [0.03%]
基于亲和色谱的leucettinib-21作用于双特异性酪氨酸磷酸化调节激酶1a（DYRK1A）靶点的小鼠脑内相互作用组学图谱研究
Emmanuel Deau,Coralie Simon,Gaëlle Hogrel et al.
Emmanuel Deau et al.
Leucettinibs are substituted 2-aminoimidazolin-4-ones inspired by the marine sponge natural product Leucettamine B and developed as pharmacological inhibitors of DYRK1A (dual-specificity, tyrosine phosphorylation-regulated kinase 1A), a the...
Blood-Brain Barrier (BBB)-Penetrable Androgen Receptor (AR) Degrader as a Potential Therapeutic Agent for Glioblastoma [0.03%]
一种潜在的治疗胶质母细胞瘤的可穿透血脑屏障的雄激素受体降解剂
Xiaotong Zhao,Yaxin Li,William R Martin et al.
Xiaotong Zhao et al.
Androgen receptor (AR) contributes to the progression of glioblastoma (GBM), which is consistent with the sex difference in GBM, which has a higher incidence in males than in females. Therefore, targeting AR is a potential therapeutic appro...
Overview of the Current Osteoarthritis Treatment in Veterinary Medicine and Future Directions [0.03%]
兽医骨关节炎治疗的现状及未来方向
Nara L M Quintão,Eduardo B Moffa,Maria Kroier et al.
Nara L M Quintão et al.
Osteoarthritis (OA) is a chronic and progressive joint disease that can cause permanent loss of joint function. OA is highly prevalent in horses, dogs, and cats, affecting different joints and leading to reduced mobility and chronic pain. D...
Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects [0.03%]
哇巴因生物电子等排体的开发：步经济合成提升镇痛和抗焦虑活性以及神经保护作用
Abhishek Gupta,Tuhin Bhattacharya,Subhamoy Pratihar et al.
Abhishek Gupta et al.
The clinical importance of iboga alkaloids lies in their efficacy in reversing drug addiction and modulating drug tolerance. However, due to safety concerns, their use is restricted to appropriate medical supervision. These alkaloids often ...