Unveiling the Role of Glutathione S‑transferase Protein in Breast Cancer Drug Resistance: Insights into the Signaling Pathways and Therapeutic Implications [0.03%]
谷胱甘肽S-转移酶蛋白在乳腺癌药物耐药中的作用机制及其信号转导和治疗意义的研究进展
Manisha Nigam,Shivangi Kukreti,Sudarshan Singh et al.
Manisha Nigam et al.
Breast cancer remains one of the most prevalent malignancies among women worldwide. Current therapeutic strategies comprising surgery, radiation therapy, immunotherapy, and postoperative chemotherapy have significantly improved patient outc...
Engineered Cell Membrane-Coated Nanoparticles: A New Strategy for Pancreatic Cancer Therapy [0.03%]
工程化细胞膜包被的纳米粒子：一种新的胰腺癌治疗策略
Ke Zhou,Zining Zhang,Bo Wang et al.
Ke Zhou et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a poor prognosis, and its treatment faces multiple challenges such as difficulties in diagnosis, a dense tumor microenvironment, and chemotherapy resistance. Cell memb...
Iminostilbene, a Carbamazepine Intermediate, Alleviates Myocardial Fibrosis after Myocardial Infarction via Targeting Galectin3 [0.03%]
靶向半乳糖凝集素3的卡马西平中间体异米诺司替宾缓解心肌梗死后的心肌纤维化
Na Li,JiaHui Zhou,Zhihui Wang et al.
Na Li et al.
Myocardial infarction (MI) induces a strong injury response, resulting in a collagen-dominated scarring. A persistent myocardial fibrotic response induces heart failure. Myocardial fibroblasts are responsible for the deposition and remodeli...
Myostatin Inhibitory D‑Peptides Induce Skeletal Muscle Hypertrophy along with Alteration of Bioactive Sphingolipid Metabolism [0.03%]
肌营养不良抑制D-肽诱导骨骼肌肥大以及生物活性鞘脂代谢的改变
Katsuya Morito,Natsuki Nishikawa,Keisuke Hitachi et al.
Katsuya Morito et al.
Myostatin inhibition is well-known as a promising strategy to induce skeletal muscle hypertrophy. Midsized peptides are currently noted as a new modality in broad drug development. Our previous studies identified a series of myostatin inhib...
Therapeutic Strategies for Hyperuricemia: From Small-Molecule Inhibitors to RNA Therapeutics [0.03%]
高尿酸血症的治疗策略：从小分子抑制剂到RNA疗法
Xi Yu,Mengjie Zhang,Yuanyu Huang
Xi Yu
Hyperuricemia is a common metabolic disorder caused by purine metabolism dysregulation or impaired uric acid excretion, and it is closely associated with gout, chronic kidney disease, and cardiovascular diseases. Conventional treatments mai...
Imaging of Fibroblast Activation Protein in the Microenvironment of Tumors by 18F‑Labeled Positron Emission Tomography Tracers with Increased Polarity [0.03%]
通过增加极性的氟-18标记正电子发射断层显像剂在肿瘤微环境中成像纤维活化蛋白
Ricardo Köchel,Stefan Wagner,Hans-Jörg Breyholz et al.
Ricardo Köchel et al.
Fibroblast activation protein (FAP) is a serine protease that is highly expressed by fibroblasts in the microenvironment of tumors. Therefore, it represents a promising target for molecular imaging and therapy of tumors. 68Ga-chelator-based...
Efficient Elimination of Microbial Infections in Wounds Using Plasma-Activated Water Hydrogel [0.03%]
高效利用等离子活化水凝胶消除伤口微生物感染的方法
Debapriya Mukherjee,Pallab Ghosh,Raju S Rajmani et al.
Debapriya Mukherjee et al.
Surgical site infections are among the most prevalent postoperative complications and remain a pressing global health challenge, exacerbated by the rise of antimicrobial resistance. Plasma-activated water (PAW) has recently gained attention...
The Prenatal Dilemma: Fever vs Acetaminophen? Navigating a Difficult Choice [0.03%]
孕期两难：发热还是服用对乙酰氨基酚？如何进行艰难的选择
Mohammad Darayesh,Elaheh Entezar Almahdi,Mirza Ali Mofazzal Jahromi et al.
Mohammad Darayesh et al.
The clinical imperative to treat maternal hyperthermia with acetaminophen is complicated by emerging evidence of the drug's association with neurodevelopmental disorders. This article examines this risk-benefit challenge and proposes a shif...
Comparative Evaluation of Gold Nanoparticles, Extracts, and Topical Formulations Prepared with Eruca sativa: Toxicity and Wound Healing Effects [0.03%]
用Eruca sativa制备的金纳米粒子、提取物和外用制剂的比较评价：毒性及伤口愈合作用
Abdullah Muhsin Hazbar,Abdulkadir Mohammed Noori Jassim,Mustafa Taha Mohammed et al.
Abdullah Muhsin Hazbar et al.
Gold nanoparticles (AuNPs) hold promise for the therapy of cancer and inflammatory conditions. Here, we describe the preparation and evaluation of novel creams obtained from AuNPs prepared with Eruca sativa for capping ("green nanoparticles...
Correction to "Comprehensive Characterization of Bruton's Tyrosine Kinase Inhibitor Specificity, Potency, and Biological Effects: Insights into Covalent and Noncovalent Mechanistic Signatures" [0.03%]
“布鲁顿酪氨酸激酶抑制剂的特异性、活性及生物学效应的全面特征分析：共价和非共价作用机制的特点”的校正评论
Antonia C Darragh,Andrew M Hanna,Justin H Lipner et al.
Antonia C Darragh et al.
[This corrects the article DOI: 10.1021/acsptsci.4c00540.]. © 2026 The Authors. Published by American Chemical Society.