Longitudinal Plasma Multiomics Characterization of Nephrotoxicity in Beagles Following Repeated Dosing of Enteric-Coated Propyl Gallate Tablets [0.03%]
包衣棓酸丙酯片重复给药后比格犬肾毒性的纵向血浆多组学表征研究
Nathaly Reyes-Garcés,Weiwen Sun,B Timothy Hummer et al.
Nathaly Reyes-Garcés et al.
Permeation enhancers (PEs) are excipients used in oral biotherapeutic formulations to facilitate the transport of bioactive compounds across the intestinal barrier and prevent their degradation. Concerns associated with the chronic use of P...
An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors [0.03%]
几种布鲁顿酪氨酸激酶(BTK)抑制剂的选择性、酶抑制动力学和体外活性评估
Ana Corrionero,Xiaohu Zhang,Patricia Alfonso et al.
Ana Corrionero et al.
Inhibitors of the Bruton's tyrosine kinase (BTK) are of broad utility in the treatment of multiple diseases including several B-cell malignancies via effective blockade of oncogenic B-cell receptor (BCR) signaling. BTK is a cytoplasmic tyro...
Reliable Determination of ATP and Its Metabolites by LC-MS Using Blood Collection Tubes with and without Ectonucleotidase Inhibitors [0.03%]
含和不含核苷酸外切酶抑制剂的血液收集管中ATP及其代谢物的可靠LC-MS测定法
Riekje Winzer,Johanna Hiefner,Romy Hackbusch et al.
Riekje Winzer et al.
Adenosine triphosphate (ATP) and its breakdown products, including adenosine, play key roles in regulating immune responses. Altered ATP and adenosine levels in blood may reflect the presence or development of various pathologies; however, ...
Proviral Integration Site for Moloney Murine Leukemia Virus 2 Suppresses Fibronectin 1 to Drive Adhesion Loss and Epithelial-Mesenchymal Transition in Multiple Myeloma [0.03%]
莫诺尼穆勒鼠白血病病毒2型原病毒整合位点通过抑制纤连蛋白1诱导多发性骨髓瘤黏附丧失和上皮间充质转化
Junna Mai,Heng Liang,Arabella H Wan et al.
Junna Mai et al.
Tumor-associated macrophages (TAMs) critically shape the multiple myeloma (MM) microenvironment, yet the molecular programs linking immune signaling to MM dissemination remain unclear. Here, we identify a TAM-derived IL6-STAT3-PIM2-cMyc-FN1...
Navigating Cancer Treatment: A Journey from 2D to 3D Cancer Models and Nanoscale Therapies [0.03%]
癌症治疗导航：从二维到三维肿瘤模型及纳米尺度疗法的旅程
Navneet Kaur,Mary Jean Savitsky,Annie Scutte et al.
Navneet Kaur et al.
Cancer remains one of the most significant global health challenges, characterized by an increasing incidence and mortality rate worldwide. In vitro models play a significant role in the initial investigations of cancer biology, drug screen...
Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry [0.03%]
基于5-(二异丙基氨基)戊胺衍生化-超高效液相色谱-串联质谱的花生四烯酸代谢产物高灵敏分析方法
Peiyan Zheng,Xiaowen Huang,Qing Wang et al.
Peiyan Zheng et al.
Arachidonic acid (AA) and its metabolites play critical roles in inflammation and immune regulation, modulating the initiation, amplification, and resolution of inflammation. However, their comprehensive quantification remains a challenging...
Study on the Effect of Puerarin-Gadolinium on Rheumatoid Arthritis Rats based on Nontargeted Metabolomics Technology [0.03%]
基于非靶向代谢组学技术的刺五加根苷-钆对类风湿关节炎大鼠作用的影响研究
Qing-Qing Ma,Hong-Zhang Cao,Ji-Hai Shi et al.
Qing-Qing Ma et al.
To find potential biomarkers and related metabolic pathways based on metabonomics of rat joint tissue, the rats with stable collagen-induced arthritis (CIA) model were taken as the research object. A rat rheumatoid arthritis model was estab...
Development and Preclinical Evaluation of a Zirconium-89-Labeled Immunoconjugate for Positron Emission Tomography Imaging of Leukemia Inhibitory Factor in Glioblastoma [0.03%]
一种用于成像胶质母细胞瘤中白血病抑制因子的放射性药物89Zr标记免疫缀合物的开发与临床前评估研究
Emily Betancourt Fernández,Julia Baguña Torres,Raffaella Iurlaro et al.
Emily Betancourt Fernández et al.
Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine secreted by tumor cells to evade immune detection, contributing to tumor progression and resistance to therapy. Targeting LIF has emerged as a promising strategy, with anti-LIF ther...
Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents [0.03%]
一种针对表皮生长因子受体的 Affibody 衍生药物缀合物共轭物具有强力且特异性的细胞毒性作用
Sara S Rinne,Wen Yin,Ruonan Li et al.
Sara S Rinne et al.
Overactive epidermal growth factor receptor (EGFR) signaling is often involved in driving different types of carcinomas. It is a well-studied target for targeted therapies, with both monoclonal antibodies and kinase inhibitors available for...
Crescent-Shaped Xanthone-Benzimidazole Conjugates as New Target Probes for Telomeric G‑Quadruplex DNA and Specific Cytotoxicity on Cancer Cells [0.03%]
新靶标探针 crescent形番 cherry酸-苯并咪唑共轭物用于端粒G-四联体DNA及对癌细胞的特异性细胞毒性作用研究
Pulakesh Pramanik,Bappa Maiti,Santanu Bhattacharya
Pulakesh Pramanik
Xanthone, an oxygenated heterotricyclic phytochemical, has recently emerged as a promising scaffold in cancer research due to its multitargeted anticancer potential. Recent studies demonstrate its affinity for G-quadruplex (G4) DNA structur...