Fishing for Contact: Modeling Perivascular Glioma Invasion in the Zebrafish Brain [0.03%]
基于斑马鱼脑模型的沿血管侵袭的胶质瘤入侵行为研究
Robyn A Umans,Mattie Ten Kate,Carolyn Pollock et al.
Robyn A Umans et al.
Glioblastoma multiforme (GBM) is a highly invasive, central nervous system (CNS) cancer for which there is no cure. Invading tumor cells evade treatment, limiting the efficacy of the current standard of care regimen. Understanding the under...
In Vitro and In Vivo Evaluation of GSK-3 Radioligands in Alzheimer's Disease: Preliminary Evidence of Sex Differences [0.03%]
阿尔茨海默病中GSK-3放射配体的体外和体内评估：初步发现性别差异证据
Ashley C Knight,Cassis Varlow,Junchao Tong et al.
Ashley C Knight et al.
Glycogen synthase kinase-3 (GSK-3) is a positron emission tomography (PET) imaging target with implications in the pathogenesis of Alzheimer's disease (AD). This preliminary study evaluates human AD and transgenic P301L mouse brain tissues ...
Design and Study of PEG Linkers That Enable Robust Characterization of PEGylated Proteins [0.03%]
一种能够使聚乙二醇修饰蛋白得到可靠表征的接头的设计与研究
Anumita Saha-Shah,Shuwen Sun,John Kong et al.
Anumita Saha-Shah et al.
Several PEGylated therapeutic proteins are approved drugs, and more are under development. However, the synthesis and characterization of these bioconjugates, especially heterogeneous mixtures of PEGylated proteins, are challenging. The pre...
DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges [0.03%]
用于药物发现的DNA编码化合物库：成功案例与未来挑战综述
Adrián Gironda-Martínez,Etienne J Donckele,Florent Samain et al.
Adrián Gironda-Martínez et al.
DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology platform for the discovery of small-molecule ligands to protein targets of biological and pharmaceutical interest. DELs are collections of molecules, indivi...
Christa E Müller
Christa E Müller
Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir [0.03%]
基于GC-376、Telaprevir和Boceprevir肽母体抑制剂共晶结构重叠的杂合SARS-CoV-2主要蛋白酶抑制剂理性设计
Zilei Xia,Michael Sacco,Yanmei Hu et al.
Zilei Xia et al.
SARS-CoV-2 main protease (Mpro) is a cysteine protease that mediates the cleavage of viral polyproteins and is a validated antiviral drug target. Mpro is highly conserved among all seven human coronaviruses, with certain Mpro inhibitors hav...
Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV-2 Spike Glycoprotein [0.03%]
识别出针对新型冠状病毒S蛋白的新型中和单克隆抗体
Devivasha Bordoloi,Ziyang Xu,Michelle Ho et al.
Devivasha Bordoloi et al.
Coronavirus disease 2019 (COVID-19) is caused by the newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the highly contagious nature of SARS-CoV-2, it has infected more than 137 million ind...
Crocodile Gut Microbiome Is a Potential Source of Novel Bioactive Molecules [0.03%]
鳄鱼肠道微生物组是新颖生物活性分子的潜在来源
Ruqaiyyah Siddiqui,Nelson Cruz Soares,Naveed Ahmed Khan
Ruqaiyyah Siddiqui
Here, it is proposed that the crocodile gut microbiome is a valuable biomaterials resource to counter threats posed by environmental and infectious hazards to the existence of Homo sapiens. ...
Artificial Intelligence Set to Reverse Engineer Drug Targeting in the Cell [0.03%]
人工智能即将逆转细胞内的药物靶点工程学
Ariel Fernández
Ariel Fernández
Therapeutic drugs are required to target proteins in the cell, not in vitro. Yet, drug-induced protein folding in vivo is off limits to computational modeling efforts. This situation may change as artificial intelligence empowers molecular ...
James W Sanders,Josjan Zijlmans
James W Sanders
The mysticism framework is used to describe psychedelic experiences and explain the effects of psychedelic therapies. We discuss risks and difficulties stemming from the scientific use of a framework associated with supernatural or nonempir...