Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats [0.03%]
评估针对卡芬太尼、芬太尼及其混合物暴露防护效果的单价和双价疫苗策略的有效性和选择性
Bethany Crouse,Mariah M Wu,Valeria Gradinati et al.
Bethany Crouse et al.
Drug-related fatal overdoses have significantly increased in the past decade due to the widespread availability of illicit fentanyl and other potent synthetic opioids such as carfentanil. Deliberate or accidental consumption or exposure to ...
2-Pyridin-4-yl-methylene-beta-boswellic Acid-A Potential Candidate for Targeting O6-Methylguanine-DNA Methyltransferase Epi-transcriptional Reprogramming in KRAS G13D-Microsatellite Stable, G12V-Microsatellite Instable Mutant Colon Cancer [0.03%]
2-吡啶-4-基-β-乳香酸甲撑茋衍生物A作为潜在靶向O6-甲基鸟嘌呤-DNA-甲基转移酶表观遗传重编程的候选药物以抑制KRAS G13D微卫星稳定型，G12V微卫星不稳定性大肠癌
Arem Qayum,Jasvinder Singh,Arvind Kumar et al.
Arem Qayum et al.
PMBA (2-Pyridin-4-yl-methylene-beta-boswellic acid), screened from among the 21 novel series of semisynthetic analogues of β-boswellic acid, is being presented as a lead compound for integrative management of KRAS mutant colorectal cancer ...
Automated Computer Software Assessment of 5-Hydroxytryptamine 2A Receptor-Mediated Head Twitch Responses from Video Recordings of Mice [0.03%]
基于小鼠视频记录的五羟色胺2A受体介导的头部摆动反应的计算机软件自动评估方法
Grant C Glatfelter,Michael R Chojnacki,Shelby A McGriff et al.
Grant C Glatfelter et al.
Psychedelics are a class of drugs that produce unique subjective effects via agonist actions at the 5-hydroxytryptamine 2A receptor (5-HT2A). The 5-HT2A-mediated head twitch response (HTR) in rodents is used as a reliable proxy for psychede...
Pharmacological Evaluation of Synthetic Dominant-Negative Peptides Derived from the Competence-Stimulating Peptide of Streptococcus pneumoniae [0.03%]
化学生物学评价来源于肺炎链球菌转化刺激肽的合成显性负性肽
Myung Whan Oh,Muralikrishna Lella,Shanny Hsuan Kuo et al.
Myung Whan Oh et al.
The competence regulon of Streptococcus pneumoniae (pneumococcus) is a quorum-sensing circuitry that regulates the ability of this pathogen to acquire antibiotic resistance or perform serotype switching, leading to vaccine-escape serotypes,...
Rapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans [0.03%]
雷帕霉素在脑海绵状血管畸形中研究：小鼠和人体试验的剂量选择
Matthew J Hagan,Robert Shenkar,Abhinav Srinath et al.
Matthew J Hagan et al.
Cerebral cavernous malformations (CCMs) are hemorrhagic neurovascular lesions that affect more than 1 million people in the United States. Rapamycin inhibits CCM development and bleeding in murine models. The appropriate dosage to modify di...
Craft of Co-encapsulation in Nanomedicine: A Struggle To Achieve Synergy through Reciprocity [0.03%]
纳米医学中的共封装技术：通过互惠实现协同效应的努力
Sourav Bhattacharjee
Sourav Bhattacharjee
Achieving synergism, often by combination therapy via codelivery of chemotherapeutic agents, remains the mainstay of treating multidrug-resistance cases in cancer and microbial strains. With a typical core-shell architecture and surface fun...
Signaling Pathways and Targeted Therapies for Stem Cells in Prostate Cancer [0.03%]
前列腺癌中的干细胞信号通路及靶向治疗
Madhuvanthi Giridharan,Vasu Rupani,Satarupa Banerjee
Madhuvanthi Giridharan
Prostate cancer (PCa) is one of the most frequently occurring cancers among men, and the current statistics show that it is the second leading cause of cancer-related deaths among men. Over the years, research in PCa treatment and therapies...
Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities [0.03%]
天然化合物抑制SARS-CoV-2 nsp13解旋酶和ATP酶活性
Angela Corona,Krzysztof Wycisk,Carmine Talarico et al.
Angela Corona et al.
SARS-CoV-2 infection is still spreading worldwide, and new antiviral therapies are an urgent need to complement the approved vaccine preparations. SARS-CoV-2 nps13 helicase is a validated drug target participating in the viral replication c...
Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney Injury [0.03%]
HDAC8抑制剂的验证作为药物发现的起点以治疗急性肾损伤
Keith Long,Zoe Vaughn,Michael David McDaniels et al.
Keith Long et al.
Acute kidney injury (AKI), a sudden loss of kidney function, is a common and serious condition for which there are no approved specific therapies. While there are multiple approaches to treat the underlying causes of AKI, no targets have be...
Hit Expansion of a Noncovalent SARS-CoV-2 Main Protease Inhibitor [0.03%]
非共价SARS-CoV-2主要蛋白酶抑制剂的作用机制扩大
Jens Glaser,Ada Sedova,Stephanie Galanie et al.
Jens Glaser et al.
Inhibition of the SARS-CoV-2 main protease (Mpro) is a major focus of drug discovery efforts against COVID-19. Here we report a hit expansion of non-covalent inhibitors of Mpro. Starting from a recently discovered scaffold (The COVID Moonsh...