Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma [0.03%]
中性粒细胞通过释放小胶质细胞外陷阱(delay修复Wallerian变性)
Yasuhiro Yamamoto,Ken Kadoya,Mohamad Alaa Terkawi et al.
Yasuhiro Yamamoto et al.
Although inflammation is indispensable for the repair process in Wallerian degeneration (WD), the role of neutrophils in the WD repair process remains unclear. After peripheral nerve injury, neutrophils accumulate at the epineurium but not ...
The vacuole shapes the nucleus and the ribosomal DNA loop during mitotic delays [0.03%]
细胞有丝分裂延缓期间液泡塑造细胞核和核糖体DNA环状结构
Emiliano Matos-Perdomo,Silvia Santana-Sosa,Jessel Ayra-Plasencia et al.
Emiliano Matos-Perdomo et al.
The ribosomal DNA (rDNA) array of Saccharomyces cerevisiae has served as a model to address chromosome organization. In cells arrested before anaphase (mid-M), the rDNA acquires a highly structured chromosomal organization referred to as th...
Efficacy of SARS-CoV-2 vaccination in patients with monoclonal gammopathies: A cross sectional study [0.03%]
针对单克隆丙球蛋白血症患者的SARS-CoV-2疫苗有效性：一项横断面研究
Eugenia Abella,Macedonia Trigueros,Edwards Pradenas et al.
Eugenia Abella et al.
SARS-CoV-2 vaccination is the most effective strategy to protect individuals with haematologic malignancies against severe COVID-19, while eliciting limited vaccine responses. We characterized the humoral responses following 3 mo after mRNA...
Comparative functional genomics identifies unique molecular features of EPSCs [0.03%]
比较功能基因组学确定了EPSC的分子特征
Vikas Malik,Ruge Zang,Alejandro Fuentes-Iglesias et al.
Vikas Malik et al.
Extended pluripotent or expanded potential stem cells (EPSCs) possess superior developmental potential to embryonic stem cells (ESCs). However, the molecular underpinning of EPSC maintenance in vitro is not well defined. We comparatively st...
Cdh5-lineage-independent origin of dermal lymphatics shown by temporally restricted lineage tracing [0.03%]
利用时空限制谱系示踪揭示皮肤淋巴管起源不受Cdh5谱系调控
Yan Zhang,Henrik Ortsäter,Ines Martinez-Corral et al.
Yan Zhang et al.
The developmental origins of lymphatic endothelial cells (LECs) have been under intense research after a century-long debate. Although previously thought to be of solely venous endothelial origin, additional sources of LECs were recently id...
Olof Asplund,Petter Storm,Vikash Chandra et al.
Olof Asplund et al.
Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 d...
Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis [0.03%]
破解单细胞RNA测序数据维度灾难问题
Yusuke Imoto,Tomonori Nakamura,Emerson G Escolar et al.
Yusuke Imoto et al.
Single-cell RNA sequencing (scRNA-seq) can determine gene expression in numerous individual cells simultaneously, promoting progress in the biomedical sciences. However, scRNA-seq data are high-dimensional with substantial technical noise, ...
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function [0.03%]
p14ARF通过与MDM2的RING和酸性结构域二价结合来抑制E3泛素连接酶功能
Dominika Kowalczyk,Mark A Nakasone,Brian O Smith et al.
Dominika Kowalczyk et al.
ARF tumor suppressor protein is a key regulator of the MDM2-p53 signaling axis. ARF interferes with MDM2-mediated ubiquitination and degradation of p53 by sequestering MDM2 in the nucleolus and preventing MDM2-p53 interaction and nuclear ex...
The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization [0.03%]
Pelado/ZSWIM8蛋白通过促进线性肌动蛋白聚合调控肌动蛋白动力学
Claudia Molina-Pelayo,Patricio Olguin,Marek Mlodzik et al.
Claudia Molina-Pelayo et al.
Actin filament polymerization can be branched or linear, which depends on the associated regulatory proteins. Competition for actin monomers occurs between proteins that induce branched or linear actin polymerization. Cell specialization re...
Ubiquitome profiling reveals a regulatory pattern of UPL3 with UBP12 on metabolic-leaf senescence [0.03%]
泛素组学分析揭示了UPL3与UBP12在代谢和叶片衰老中的调控模式
Wei Lan,Weibo Ma,Shuai Zheng et al.
Wei Lan et al.
The HECT-type UPL3 ligase plays critical roles in plant development and stress protection, but understanding of its regulation remains limited. Here, the multi-omics analyses of ubiquitinated proteins in <i>upl3</i> mutants were performed. ...