Semaphorin 6D-expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung [0.03%]
肺部间充质细胞表达的_semaphore_6D调节ILC2s产生的IL-10
Maiko Naito,Yoshimitsu Nakanishi,Yasutaka Motomura et al.
Maiko Naito et al.
Group 2 innate lymphoid cells (ILC2s) have been implicated in both physiologic tissue remodeling and allergic pathology, yet the niche signaling required for ILC2 properties is poorly understood. Here, we show that an axonal guidance cue se...
Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma [0.03%]
组蛋白乙酰化介导的MST2降解对黑素瘤BRAF抑制剂抗性的作用及其机制研究
David Romano,Lucía García-Gutiérrez,Nourhan Aboud et al.
David Romano et al.
The RAS-RAF-MEK-ERK pathway is hyperactivated in most malignant melanomas, and mutations in BRAF or NRAS account for most of these cases. BRAF inhibitors (BRAFi) are highly efficient for treating patients with BRAFV600E mutations, but tumou...
Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity [0.03%]
敲除下丘脑POMC神经元中连接内侧杏仁核的Magel2基因可降低饮食诱导型肥胖的易感性
Yuna Choi,Hyeon-Young Min,Jiyeon Hwang et al.
Yuna Choi et al.
Hyperphagia and obesity profoundly affect the health of children with Prader-Willi syndrome (PWS). The Magel2 gene among the genes in the Prader-Willi syndrome deletion region is expressed in proopiomelanocortin (POMC) neurons in the arcuat...
Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells [0.03%]
肠道单细胞图谱揭示了与人类细胞相似的新型猪淋巴细胞
Jayne E Wiarda,Julian M Trachsel,Sathesh K Sivasankaran et al.
Jayne E Wiarda et al.
Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte function is challenging as the intestine contains a vastly heterogeneous mixture of cells. Pigs are an advantageous biomedical model, but deeper unders...
Binding stoichiometry and structural model of the HIV-1 Rev/importin β complex [0.03%]
HIV-1 Rev/进口蛋白β复合体的结合比例和结构模型
Didier Spittler,Rose-Laure Indorato,Elisabetta Boeri Erba et al.
Didier Spittler et al.
HIV-1 Rev mediates the nuclear export of intron-containing viral RNA transcripts and is essential for viral replication. Rev is imported into the nucleus by the host protein importin β (Impβ), but how Rev associates with Impβ is poorly u...
Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis [0.03%]
RGS的磷酸化调节MAP激酶定位并促进细胞分裂末期完成
William C Simke,Cory P Johnson,Andrew J Hart et al.
William C Simke et al.
Yeast use the G-protein-coupled receptor signaling pathway to detect and track the mating pheromone. The G-protein-coupled receptor pathway is inhibited by the regulator of G-protein signaling (RGS) Sst2 which induces Gα GTPase activity an...
FKBP4 regulates 5-fluorouracil sensitivity in colon cancer by controlling mitochondrial respiration [0.03%]
FKBP4通过控制线粒体呼吸调节结直肠癌细胞对氟尿嘧啶的敏感性
Zhenyu Zhu,Qingsheng Hou,Bishi Wang et al.
Zhenyu Zhu et al.
Mitochondrial respiration and metabolism play a key role in the pathogenesis and progression of colon adenocarcinoma (COAD). Here, we report a functional pool of FKBP4, a co-chaperone protein, in the mitochondrial intermembrane space (IMS) ...
Mitotic H3K9ac is controlled by phase-specific activity of HDAC2, HDAC3, and SIRT1 [0.03%]
组蛋白脱乙酰酶HDAC2、HDAC3和SIRT1相位特异性活性调控有丝分裂H3K9乙酰化状态
Shashi Gandhi,Raizy Mitterhoff,Rachel Rapoport et al.
Shashi Gandhi et al.
Histone acetylation levels are reduced during mitosis. To study the mitotic regulation of H3K9ac, we used an array of inhibitors targeting specific histone deacetylases. We evaluated the involvement of the targeted enzymes in regulating H3K...
Molecular insights into high-altitude adaption and acclimatisation of Aporrectodea caliginosa [0.03%]
赤红管翅螠适应和习服高海拔环境的分子机制研究
Iain Perry,Szabolcs Balazs Hernadi,Luis Cunha et al.
Iain Perry et al.
Here, we explore the high-altitude adaptions and acclimatisation of Aporrectodea caliginosa Population diversity is assessed through mitochondrial barcoding, identifying closely related populations across the island of Pico (Azores). We pre...
Telescoping bimodal latent Dirichlet allocation to identify expression QTLs across tissues [0.03%]
一种用于识别组织间表达QTL的双模潜在狄利克雷分配方法
Ariel Dh Gewirtz,F William Townes,Barbara E Engelhardt
Ariel Dh Gewirtz
Expression quantitative trait loci (eQTLs), or single-nucleotide polymorphisms that affect average gene expression levels, provide important insights into context-specific gene regulation. Classic eQTL analyses use one-to-one association te...