Contribution of the Golgi apparatus in morphogenesis of a virus-induced cytopathic vacuolar system [0.03%]
高尔基体在病毒诱导的细胞病变囊泡系统形态发生中的作用
Ranjan Sengupta,Elaine M Mihelc,Stephanie Angel et al.
Ranjan Sengupta et al.
The Golgi apparatus (GA) in mammalian cells is pericentrosomally anchored and exhibits a stacked architecture. During infections by members of the alphavirus genus, the host cell GA is thought to give rise to distinct mobile pleomorphic vac...
A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2 [0.03%]
CA重复是神经元MeCP2主要靶点假说的批判研究论文
Kashyap Chhatbar,John Connelly,Shaun Webb et al.
Kashyap Chhatbar et al.
The DNA-binding protein MeCP2 is reported to bind methylated cytosine in CG and CA motifs in genomic DNA, but it was recently proposed that arrays of tandemly repeated CA containing either methylated or hydroxymethylated cytosine are the pr...
Alexander Siebert,Vanessa Gattringer,Jochen H Weishaupt et al.
Alexander Siebert et al.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA ...
RSC and GRFs confer promoter directionality by restricting divergent noncoding transcription [0.03%]
RSC和GRF通过限制发散的非编码转录来赋予启动子方向性
Andrew Ck Wu,Claudia Vivori,Harshil Patel et al.
Andrew Ck Wu et al.
The directionality of gene promoters-the ratio of protein-coding over divergent noncoding transcription-is highly variable. How promoter directionality is controlled remains poorly understood. Here, we show that the chromatin remodelling co...
Ataxin-2, Twenty-four, and Dicer-2 are components of a noncanonical cytoplasmic polyadenylation complex [0.03%]
Ataxin-2、ATXN2L 和 Dicer-2 是非经典胞质多聚腺苷酸化复合物的组成部分
Hima Priyanka Nadimpalli,Tanit Guitart,Olga Coll et al.
Hima Priyanka Nadimpalli et al.
Cytoplasmic polyadenylation is a mechanism to promote mRNA translation in a wide variety of biological contexts. A canonical complex centered around the conserved RNA-binding protein family CPEB has been shown to be responsible for this pro...
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions [0.03%]
基于人类细胞的增效遗传筛选鉴定出可克服环境营养限制的SLC转运蛋白
Manuele Rebsamen,Enrico Girardi,Vitaly Sedlyarov et al.
Manuele Rebsamen et al.
Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functiona...
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology [0.03%]
线粒体障碍和细胞内活性氧可改变主要纤毛形态
Noah Moruzzi,Ismael Valladolid-Acebes,Sukanya A Kannabiran et al.
Noah Moruzzi et al.
Primary cilia have recently emerged as cellular signaling organelles. Their homeostasis and function require a high amount of energy. However, how energy depletion and mitochondria impairment affect cilia have barely been addressed. We firs...
Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological aging [0.03%]
来源于早衰综合征患者的间充质干细胞表现出生理衰老的特征
Jean Philippe Trani,Raphaël Chevalier,Leslie Caron et al.
Jean Philippe Trani et al.
Progeroid syndromes are rare genetic diseases with most of autosomal dominant transmission, the prevalence of which is less than 1/10,000,000. These syndromes caused by mutations in the <i>LMNA</i> gene encoding A-type lamins belong to a gr...
Sibling rivalry among the ZBTB transcription factor family: homodimers versus heterodimers [0.03%]
ZBTB转录因子家族的同族竞争：同源二聚体与异源二聚体之间的较量
Sofia Piepoli,Sarah Barakat,Liyne Nogay et al.
Sofia Piepoli et al.
The BTB domain is an oligomerization domain found in over 300 proteins encoded in the human genome. In the family of BTB domain and zinc finger-containing (ZBTB) transcription factors, 49 members share the same protein architecture. The N-t...
α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes [0.03%]
α-actinin-4通过在足细胞中募集Shp2到焦粘着斑来增强ROCK2活化
Chien-Chun Tseng,Ru-Hsuan Zheng,Ting-Wei Lin et al.
Chien-Chun Tseng et al.
Cell-matrix adhesions are mainly provided by integrin-mediated focal adhesions (FAs). We previously found that Shp2 is essential for FA maturation by promoting ROCK2 activation at FAs. In this study, we further delineated the role of α-act...