VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome [0.03%]
VEGFR3在22q11.2缺失综合征小鼠模型中调节脑微血管分支
Sara Cioffi,Gemma Flore,Stefania Martucciello et al.
Sara Cioffi et al.
The loss of a single copy of <i>TBX1</i> accounts for most of the clinical signs and symptoms of 22q11.2 deletion syndrome, a common genetic disorder that is characterized by multiple congenital anomalies and brain-related clinical problems...
Correction: The intracellular pathogen Francisella escapes from adaptive immunity by metabolic adaptation [0.03%]
Correction：胞内致病菌弗朗西斯菌通过代谢适应逃逸适应性免疫攻击
Kensuke Shibata,Takashi Shimizu,Mashio Nakahara et al.
Kensuke Shibata et al.
This study shows that this metabolic adaptation allows the intracellular bacterial pathogen Francisella tularensis to escape recognition by the host adaptive immunity.
Published Erratum
Life science alliance. 2022 Oct 10;5(11):e202201733. DOI:10.26508/lsa.202201733 2022
Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16 [0.03%]
非规范的miRNA-RNA碱基配对削弱了miR-16的抑癌功能
Anaïs M Quéméner,Laura Bachelot,Marc Aubry et al.
Anaïs M Quéméner et al.
Uveal melanoma (UM), the most common primary intraocular tumor in adults, has been extensively characterized by omics technologies during the last 5 yr. Despite the discovery of gene signatures, the molecular actors driving cancer aggressiv...
Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons [0.03%]
致命家族失眠症中的转录组分析揭示了TOR信号在生长抑素能神经元中的作用
Susanne Bauer,Lars Dittrich,Lech Kaczmarczyk et al.
Susanne Bauer et al.
Selective neuronal vulnerability is common in neurodegenerative diseases but poorly understood. In genetic prion diseases, including fatal familial insomnia (FFI) and Creutzfeldt-Jakob disease (CJD), different mutations in the Prnp gene man...
Nodal and <i>churchill1</i> position the expression of a notch ligand during <i>Xenopus</i> germ layer segregation [0.03%]
结节和churchill1位点的 notch配体基因在非洲爪蟾胚层分化的表达中的作用
María Belén Favarolo,Diego R Revinski,Matías J Garavaglia et al.
María Belén Favarolo et al.
In vertebrates, Nodal signaling plays a major role in endomesoderm induction, but germ layer delimitation is poorly understood. In avian embryos, the neural/mesoderm boundary is controlled by the transcription factor CHURCHILL1, presumably ...
Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor [0.03%]
基于T7 RNA聚合酶的随机DNA碱基编辑器合成进化出除草剂抗性
Haroon Butt,Jose Luis Moreno Ramirez,Magdy Mahfouz
Haroon Butt
Synthetic directed evolution via localized sequence diversification and the simultaneous application of selection pressure is a promising method for producing new, beneficial alleles that affect traits of interest in diverse species; howeve...
Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer's model [0.03%]
口服PGD2受体拮抗剂TIMAPIPRANT改善阿尔茨海默病模型大鼠的病理变化
Charles H Wallace,Giovanni Oliveros,Peter A Serrano et al.
Charles H Wallace et al.
We investigated the relevance of the prostaglandin D2 pathway in Alzheimer's disease, because prostaglandin D2 is a major prostaglandin in the brain. Thus, its contribution to Alzheimer's disease merits attention, given the known impact of ...
Building in vitro models of the brain to understand the role of APOE in Alzheimer's disease [0.03%]
构建脑类器官模型以了解APOE在阿尔茨海默病中的作用
Rebecca L Pinals,Li-Huei Tsai
Rebecca L Pinals
Alzheimer's disease (AD) is a devastating, complex, and incurable disease that represents an increasingly problematic global health issue. The etiology of sporadic AD that accounts for a vast majority of cases remains poorly understood, wit...
miR-329- and miR-495-mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neurons [0.03%]
小胶质细胞活化诱导的微小核糖核酸-329和微小核糖核酸-495通过靶向光周期反应7介导大鼠海马神经元稳态突触抑制所必需
Michiko O Inouye,David Colameo,Irina Ammann et al.
Michiko O Inouye et al.
Homeostatic synaptic depression (HSD) in excitatory neurons is a cell-autonomous mechanism which protects excitatory neurons from over-excitation as a consequence of chronic increases in network activity. In this process, excitatory synapse...
Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain [0.03%]
CASK通过其钙调神经磷酸酶结构域调控Liprin-α的相分离这一过程被该位点的一个突变所破坏
Debora Tibbe,Pia Ferle,Christoph Krisp et al.
Debora Tibbe et al.
CASK is a unique membrane-associated guanylate kinase (MAGUK) because of its Ca2+/calmodulin-dependent kinase (CaMK) domain. We describe four male patients with a severe neurodevelopmental disorder with microcephaly carrying missense varian...