Cross talk between glucose metabolism and immunosuppression in IFN-γ-primed mesenchymal stem cells [0.03%]
干扰素γ诱导的间充质干细胞中葡萄糖代谢与免疫抑制作用的相互调节关系研究
Mengwei Yao,Zhuo Chen,Xiao He et al.
Mengwei Yao et al.
The immunosuppressive function "licensed" by IFN-γ is a vital attribute of mesenchymal stem cells (MSCs) widely used in the treatment of inflammatory diseases. However, the mechanism and impact of metabolic reprogramming on MSC immunomodul...
The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import [0.03%]
_ubc8通过代谢物调控的泛素连接酶促进线粒体蛋白的输入
Saskia Rödl,Fabian den Brave,Markus Räschle et al.
Saskia Rödl et al.
Mitochondria play a key role in cellular energy metabolism. Transitions between glycolytic and respiratory conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced f...
Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment [0.03%]
针对CD32 T细胞的直接细胞毒性作用：对乳腺癌预后和治疗的意义
Giuseppe Sconocchia,Giulia Lanzilli,Valeriana Cesarini et al.
Giuseppe Sconocchia et al.
The FcγRII (CD32) ligands are IgFc fragments and pentraxins. The existence of additional ligands is unknown. We engineered T cells with human chimeric receptors resulting from the fusion between CD32 extracellular portion and transmembrane...
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication [0.03%]
EXOSC2低表达可防止新冠肺炎并抑制SARS-CoV-2复制
Tobias Moll,Valerie Odon,Calum Harvey et al.
Tobias Moll et al.
New therapeutic targets are a valuable resource for treatment of SARS-CoV-2 viral infection. Genome-wide association studies have identified risk loci associated with COVID-19, but many loci are associated with comorbidities and are not spe...
A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering [0.03%]
一种显性的负向mitofusin导致线粒体出现细胞核周围聚集，这是由于异常附着所致
Stephanie R Sloat,Suzanne Hoppins
Stephanie R Sloat
In vertebrates, mitochondrial outer membrane fusion is mediated by two mitofusin paralogs, Mfn1 and Mfn2, conserved dynamin superfamily proteins. Here, we characterize a variant of mitofusin reported in patients with CMT2A where a serine is...
Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy [0.03%]
差异性铂敏感的卵巢癌全外显子组测序
Viktor Hlaváč,Petr Holý,Radka Václavíková et al.
Viktor Hlaváč et al.
Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected EOC. Compared with s...
Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus [0.03%]
自身免疫RNA异常与癫痫发作：狼疮性神经精神系统的治疗前景
Ilham A Muslimov,Valerio Berardi,Stacy Stephenson et al.
Ilham A Muslimov et al.
Lupus autoimmunity frequently presents with neuropsychiatric manifestations, but underlying etiology remains poorly understood. Human brain cytoplasmic 200 RNA (BC200 RNA) is a translational regulator in neuronal synapto-dendritic domains. ...
High-resolution structure of a fish aquaporin reveals a novel extracellular fold [0.03%]
鱼 aquaporin 的高分辨率结构揭示了一种新的细胞外折叠方式
Jiao Zeng,Florian Schmitz,Simon Isaksson et al.
Jiao Zeng et al.
Aquaporins are protein channels embedded in the lipid bilayer in cells from all organisms on earth that are crucial for water homeostasis. In fish, aquaporins are believed to be important for osmoregulation; however, the molecular mechanism...
Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes [0.03%]
呼吸驱动的肺适应及气细胞分化取决于可变剪切调控机制
Marta F Fidalgo,Catarina G Fonseca,Paulo Caldas et al.
Marta F Fidalgo et al.
Adaptation to breathing is a critical step in lung function and it is crucial for organismal survival. Alveoli are the lung gas exchange units and their development, from late embryonic to early postnatal stages, requires feedbacks between ...
Exploratory meta-analysis of hypoxic transcriptomes using a precise transcript reference sequence set [0.03%]
使用精确的转录参考序列集进行缺氧转录组的探索性元分析研究
Yoko Ono,Hidemasa Bono
Yoko Ono
Gene expression studies are intrinsically biased, with many studies influenced by concomitant information such as gene-disease associations. This limitation can be overcome using a data-driven analysis approach without relying on ancillary ...