Correction: CDKL3 promotes osteosarcoma progression by activating Akt/PKB [0.03%]
关于CDKL3通过激活Akt/PKB促进骨肉瘤发展的更正公告
Aina He,Lanjing Ma,Yujing Huang et al.
Aina He et al.
This study demonstrates that CDKL3 regulates Akt activation and its downstream targets to promote OS progression, creating a therapeutically targetable vulnerability in treatment of OS.
Published Erratum
Life science alliance. 2022 Oct 21;5(11):e202201656. DOI:10.26508/lsa.202201656 2022
MDF is a conserved splicing factor and modulates cell division and stress response in Arabidopsis [0.03%]
MDF是一种保守的剪接因子并调控拟南芥细胞分裂及胁迫响应
Cloe de Luxán-Hernández,Julia Lohmann,Eduardo Tranque et al.
Cloe de Luxán-Hernández et al.
The coordination of cell division with stress response is essential for maintaining genome stability in plant meristems. Proteins involved in pre-mRNA splicing are important for these processes in animal and human cells. Based on its homolo...
Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in the dystrophic muscle in Duchenne muscular dystrophy [0.03%]
Dlk1-Dio3簇miRNA调节杜氏肌营养不良退行性肌肉的线粒体功能
Ai Vu Hong,Nathalie Bourg,Peggy Sanatine et al.
Ai Vu Hong et al.
Duchenne muscular dystrophy (DMD) is a severe muscle disease caused by impaired expression of dystrophin. Whereas mitochondrial dysfunction is thought to play an important role in DMD, the mechanism of this dysfunction remains to be clarifi...
An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65 [0.03%]
诱导性两亲α-螺旋介导RPE65的细胞内定位和膜结合作用
Sheetal Uppal,Tingting Liu,Emily Galvan et al.
Sheetal Uppal et al.
RPE65 retinol isomerase is an indispensable player in the visual cycle between the vertebrate retina and RPE. Although membrane association is critical for RPE65 function, its mechanism is not clear. Residues 107-125 are believed to interac...
A prediction model for COVID-19 liver dysfunction in patients with normal hepatic biochemical parameters [0.03%]
正常肝生化参数冠状病毒病肝损伤预测模型
Jianfeng Bao,Shourong Liu,Xiao Liang et al.
Jianfeng Bao et al.
Coronavirus disease 2019 (COVID-19) patients with liver dysfunction (LD) have a higher chance of developing severe and critical disease. The routine hepatic biochemical parameters ALT, AST, GGT, and TBIL have limitations in reflecting COVID...
Replication-associated inversions are the dominant form of bacterial chromosome structural variation [0.03%]
复制相关倒位是细菌染色体结构变异的主要形式
Matthew D&#x;Iorio,Ken Dewar
Matthew D&#x;Iorio
The structural arrangements of bacterial chromosomes vary widely between closely related species and can result in significant phenotypic outcomes. The appearance of large-scale chromosomal inversions that are symmetric relative to markers ...
Tandemly repeated NBPF HOR copies (Olduvai triplets): Possible impact on human brain evolution [0.03%]
串联重复的NBPF霍乱毒素基因家族成员（ Olduvai三联体）：对人类大脑进化的影响的可能性
Matko Glunčić,Ines Vlahović,Marija Rosandić et al.
Matko Glunčić et al.
Previously it was found that the neuroblastoma breakpoint family (NBPF) gene repeat units of ∼1.6 kb have an important role in human brain evolution and function. The higher order organization of these repeat units has been discovered by b...
Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival [0.03%]
甲硫氨酸通过SLC43A2转运蛋白对于调节性T细胞的存活是必不可少的
Neetu Saini,Afsana Naaz,Shree Padma Metur et al.
Neetu Saini et al.
Cell death, survival, or growth decisions in T-cell subsets depend on interplay between cytokine-dependent and metabolic processes. The metabolic requirements of T-regulatory cells (Tregs) for their survival and how these are satisfied rema...
The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health [0.03%]
L-NAME子痫前期小鼠模型及其对长期心血管健康的影响
Natasha de Alwis,Natalie K Binder,Sally Beard et al.
Natasha de Alwis et al.
Preeclampsia affects ∼2-8% of pregnancies worldwide. It is associated with increased long-term maternal cardiovascular disease risk. This study assesses the effect of the vasoconstrictor N(ω)-nitro-L-arginine methyl ester (L-NAME) in mode...
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments [0.03%]
依托霉素通过抑制蛋白质合成而非靶向Okazaki片段阻断DNA复制
David Lukac,Zuzana Machacova,Pavel Moudry
David Lukac
DNA synthesis of the leading and lagging strands works independently and cells tolerate single-stranded DNA generated during strand uncoupling if it is protected by RPA molecules. Natural alkaloid emetine is used as a specific inhibitor of ...