C-to-U RNA deamination is the driving force accelerating SARS-CoV-2 evolution [0.03%]
C到U的RNA脱氨是推动SARS-CoV-2 进化的驱动力
Yan Li,Fanghua Hou,Meili Zhou et al.
Yan Li et al.
Understanding the molecular mechanism underlying the rampant mutation of SARS-CoV-2 would help us control the COVID-19 pandemic. The APOBEC-mediated C-to-U deamination is a major mutation type in the SARS-CoV-2 genome. However, it is unclea...
The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokine [0.03%]
表达嵌合细胞因子的通用流感病毒样颗粒疫苗的潜力
Kuniaki Nerome,Toshifumi Imagawa,Shigeo Sugita et al.
Kuniaki Nerome et al.
The efficacy of the current influenza vaccines is frequently reduced because of antigenic drift, a trade-off of developing improved vaccines with broad cross-protective activity against influenza A viruses. In this study, we have successful...
Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing [0.03%]
靶向捕获测序在多发性骨髓瘤免疫球蛋白重排及易位检测中的应用
Signy Chow,Olena Kis,David T Mulder et al.
Signy Chow et al.
Multiple myeloma is a plasma cell neoplasm characterized by clonal immunoglobulin V(D)J signatures and oncogenic immunoglobulin gene translocations. Additional subclonal genomic changes are acquired with myeloma progression and therapeutic ...
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis [0.03%]
丹参酮作为辅酶赋予NQO1功能以抑制铁死亡
Tian-Xiang Wang,Kun-Long Duan,Zi-Xuan Huang et al.
Tian-Xiang Wang et al.
Ferroptosis is triggered by the breakdown of cellular iron-dependent redox homeostasis and the abnormal accumulation of lipid ROS. Cells have evolved defense mechanisms to prevent lipid ROS accumulation and ferroptosis. Using a library of m...
CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau [0.03%]
运用 CRISPRi 筛查技术发现调节tau病理的小分子及囊泡体内、体外作用的调控因子
Juan Carlos Polanco,Yevhen Akimov,Avinash Fernandes et al.
Juan Carlos Polanco et al.
The aggregation of the microtubule-associated protein tau is a defining feature of Alzheimer's disease and other tauopathies. Tau pathology is believed to be driven by free tau aggregates and tau carried within exosome-like extracellular ve...
In vivo probing of SECIS-dependent selenocysteine translation in Archaea [0.03%]
古细菌中依赖SECIS的硒半胱氨酸翻译的体内探测
Nils Peiter,Michael Rother
Nils Peiter
Cotranslational insertion of selenocysteine (Sec) proceeds by recoding UGA to a sense codon. This recoding is governed by the Sec insertion sequence (SECIS) element, an RNA structure on the mRNA, but size, location, structure determinants, ...
Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers [0.03%]
棕榈酸通过组蛋白修饰增强子损害肌细胞转录组的昼夜节律性
Nicolas J Pillon,Laura Sardón Puig,Ali Altıntaş et al.
Nicolas J Pillon et al.
Obesity and elevated circulating lipids may impair metabolism by disrupting the molecular circadian clock. We tested the hypothesis that lipid overload may interact with the circadian clock and alter the rhythmicity of gene expression throu...
circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy [0.03%]
环状RNA circEXOC5通过PTBP1/Skp2/Runx2轴激活自噬促进急性肺损伤
Pei Gao,Beirong Wu,Ying Ding et al.
Pei Gao et al.
To understand the pathogenesis of acute lung injury (ALI), we focused on circEXOC5, a significantly up-regulated circular RNA in ALI. Using the in vivo cecal ligation and puncture (CLP)-induced ALI mouse model and in vitro LPS-challenged mo...
Miro GTPase domains regulate the assembly of the mitochondrial motor-adaptor complex [0.03%]
Miro 鞘蛋白结构域调节线粒体马达-适配体复合物的组装
Kayla Davis,Himanish Basu,Ismael Izquierdo-Villalba et al.
Kayla Davis et al.
Mitochondrial transport relies on a motor-adaptor complex containing Miro1, a mitochondrial outer membrane protein with two GTPase domains, and TRAK1/2, kinesin-1, and dynein. Using a peroxisome-directed Miro1, we quantified the ability of ...
Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II [0.03%]
Rng2的肌动蛋白结合域弱结合F-actin并强烈抑制肌球蛋白II对actin的滑动效应
Yuuki Hayakawa,Masak Takaine,Kien Xuan Ngo et al.
Yuuki Hayakawa et al.
We report a case in which sub-stoichiometric binding of an actin-binding protein has profound structural and functional consequences, providing an insight into the fundamental properties of actin regulation. Rng2 is an IQGAP contained in co...