A simple, efficient, and scalable method to generate oocyte-like cells in vitro [0.03%]
一种简单高效且可扩展的体外生成卵细胞样细胞的方法
Ami Banno,Kana Mizuno,Mizuki Sakamoto et al.
Ami Banno et al.
Understanding the molecular basis of oocyte identity and function is essential not only for basic biology but also for clinical applications, as it is closely linked to female infertility. However, technical challenges remain in advancing t...
SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mice [0.03%]
SOX2是小鼠NUT癌发生的可有可无的调节因子
Chenxiang Luo,Dejin Zheng,Ahmed Elnegiry et al.
Chenxiang Luo et al.
NUT carcinoma (NC) is an aggressive malignancy driven by BRD4::NUTM1 and other NUTM1 fusion oncogenes. BRD4::NUTM1 aberrantly activates transcription factors (TFs) associated with basal progenitor cells of stratified epithelium, resulting i...
Müller cell glutamine metabolism links photoreceptor and endothelial injury in diabetic retinopathy [0.03%]
Müller细胞谷氨酰胺代谢在糖尿病视网膜病变的感光细胞和内皮细胞损伤中的联系
Katia Corano Scheri,Yi-Wen Hsieh,Thomas Tedeschi et al.
Katia Corano Scheri et al.
We characterized the timeline of molecular dysfunction in diabetic retinopathy (DR) and diabetic retinal disease (DRD) by studying the streptozotocin (STZ)-induced mouse retina over the course of 6 mo of diabetes. We performed bulk RNA-Seq ...
Identifying space-resolved proteins of the murine thymus, by combining MALDI-MSI and proteomics [0.03%]
结合质谱成像和蛋白质组学识别鼠胸腺空间分辨蛋白
Jennifer T Aguilan,Carlos Madrid-Aliste,Joshua Fischer et al.
Jennifer T Aguilan et al.
Identifying spatially resolved proteomes has advanced markedly, yet integrating definitive protein identification with precise spatial localization in a single workflow remains challenging. Matrix-assisted laser desorption/ionization mass s...
Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data [0.03%]
基于机器学习的同源重组缺陷调节物的鉴定及其多组学数据的相关性分析
Renan Valieris,Lucas Rosa,Luan Martins et al.
Renan Valieris et al.
Homologous recombination deficiency (HRD) is a critical biomarker for guiding targeted therapies, yet the full range of somatic alterations driving HRD across cancers remains incompletely characterized. Here, we present a tumor-agnostic mac...
Polyphyletic screen defines distinct classes of plant-derived natural products that oppose tauopathy [0.03%]
多谱系筛选定义了若干类拮抗tau蛋白病的植物来源天然产物类群
Chatrawee D Shepard,Xinmin Chang,Paul M Seidler et al.
Chatrawee D Shepard et al.
Alzheimer's disease (AD) is a debilitating neurodegenerative disease hallmarked by the presence of amyloid-β (Aβ) plaques and tau fibrils but with limited treatment options. Here, we describe two plant-derived natural products with distin...
The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development [0.03%]
VelBIDD促进 velvet蛋白的选择性异二聚体形成以调控真菌发育
Anna M Köhler,Sabine Thieme,Jennifer Gerke et al.
Anna M Köhler et al.
Fungi possess several transcription factors with a characteristic velvet domain for DNA binding and homo- or heterodimerization, which is structurally similar to the mammalian NF-κB Rel homology domain. Velvet dimers control fungal develop...
Group 1 mGluR stimulation rescues APOE4-mediated translation defects in neurons [0.03%]
mGluR1受体激动恢复APOE4介导的神经元翻译缺陷
Bindushree K Radhakrishna,Ahamed P Kaladiyil,Anushree Chakraborty et al.
Bindushree K Radhakrishna et al.
The E4 isoform of apolipoprotein (APOE4) is the most recognized risk factor for Alzheimer's disease, implicated in early neurodegeneration and impaired synaptic plasticity. In neurons, exposure to APOE4 disrupts basal and NMDAR-mediated cal...
Chameau (HBO1) regulates starvation resistance in Drosophila melanogaster in a temperature-dependent manner [0.03%]
体温依赖性调控果蝇禁食耐受的基因CHAMEAU(HBO1)
Anuroop Venkateswaran Venkatasubramani,Toshiharu Ichinose,Ignasi Forne et al.
Anuroop Venkateswaran Venkatasubramani et al.
The body temperature of Drosophila melanogaster depends on the extrinsic temperature. Numerous studies show that environmental temperature influences metabolism, lifespan, and starvation resilience. We have previously shown that Chameau (Ch...
Aberrant NSUN1 activity connects m5C-RNA modification to TDP-43 neurotoxicity in ALS/FTD [0.03%]
异常的NSUN1活性将m5C-RNA修饰与ALS / FTD中的TDP-43神经毒性联系起来
Melissa Parra-Torres,Kumara Dissanayake,James A Gray et al.
Melissa Parra-Torres et al.
In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the nuclear RNA-binding protein TDP-43 mislocalises to the cytoplasm and forms insoluble aggregates, but the mechanisms controlling this remain unclear. We define a n...