Structure and dynamics of 2x(CENP-A/H4)2 octasome reveal a possible intermediate in centromeric chromatin [0.03%]
二价CENP-A八聚体结构揭示了着丝粒染色质中间态的可能组成形式
Ahmad Ali-Ahmad,Mira Mors,Manuel Carrer et al.
Ahmad Ali-Ahmad et al.
The centromere is a part of the chromosome that is essential for the even segregation of duplicated chromosomes during cell division. It is epigenetically defined by the presence of the histone H3 variant CENP-A. CENP-A associates specifica...
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration [0.03%]
胆碱能神经元昼夜钟在RNA代谢及介导神经退行性疾病发生中的作用
Sharon B Tam,Nathan J Waldeck,Matthew Wright et al.
Sharon B Tam et al.
Circadian clocks are encoded by a transcription-translation feedback loop that aligns physiological processes with the solar cycle. Previous work linking the circadian clock to the regulation of RNA-binding proteins (RBPs) provides a founda...
Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers [0.03%]
阿爾茨海默病患者中Y染色體丢失与CHIP驱动因子之外的体细胞突变共发生
Edyta Rychlicka-Buniowska,Daniil Sarkisyan,Monika Horbacz et al.
Edyta Rychlicka-Buniowska et al.
Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events with implications for aging and Alzheimer disease (AD). LOY is linked to increased AD risk, whereas CHIP may be protective, ...
A step-by-step guide to performing cancer metabolism research using custom-made media [0.03%]
使用定制培养基进行癌症代谢研究的逐步指南
Sophie Seifert,Francisco Yanqui-Rivera,Tim Kühn et al.
Sophie Seifert et al.
The preparation of custom-made media offers precise control over nutrient composition, enabling detailed studies of cellular metabolism. We demonstrate how self-made media formulations enable diverse assay designs and readouts to assess can...
Veysel Oğulcan Kaya,Ogün Adebali,Hanspeter Naegeli et al.
Veysel Oğulcan Kaya et al.
The mammalian genome is hierarchically structured to maintain accessibility and flexibility for essential nuclear processes such as transcription and DNA repair. A recent study using high-throughput 3D genome mapping reveals that nucleotide...
Correction: Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity [0.03%]
纠正：瞬时PU.1低胎儿祖细胞产生淋巴系后代以贡献成人免疫系统
Encarnacion Montecino-Rodriguez,Oscar I Estrada,Kenneth Dorshkind
Encarnacion Montecino-Rodriguez
Transient PU.1low fetal progenitors generate activated and memory T and B cells that colonize and are maintained in secondary lymphoid tissues and make an early and long-term contribution to the adult immune system.
Published Erratum
Life science alliance. 2025 Dec 2;9(2):e202503567. DOI:10.26508/lsa.202503567 2025
GPR88 localization to primary cilia in neurons is cell-type specific [0.03%]
GPR88定位到神经元原纤毛上具有细胞类型特异性
Yenni H Li Guan,Brigitte L Kieffer,Mark von Zastrow et al.
Yenni H Li Guan et al.
GPR88 is an orphan G protein-coupled receptor that regulates dopamine neurotransmission and is a target for neuropsychiatric disorders. In addition to the somatic membrane, GPR88 can localize to the primary cilium, a membrane microdomain kn...
Correction: Proteomic-based stratification of intermediate-risk prostate cancer patients [0.03%]
纠正基于蛋白质组学的中危前列腺癌患者的分层方法
Qing Zhong,Rui Sun,Adel T Aref et al.
Qing Zhong et al.
This study demonstrates the ability of a protein-based signature to risk-stratify prostate cancer patients with Gleason grade groups 2 and 3 and predict the risk of biochemical recurrence.
Published Erratum
Life science alliance. 2025 Dec 1;9(2):e202503547. DOI:10.26508/lsa.202503547 2025
The unfolded protein response in progeria arteries originates from non-endothelial cell types [0.03%]
霍奇金淋巴瘤的免疫疗法响应中的空间可塑性及非细胞自主调节因素的影响
Raquel A Silva,Fatih Sarigol,G Elif Karagöz et al.
Raquel A Silva et al.
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease caused by a mutation in LMNA, leading to the expression of a prelamin A variant called progerin. HGPS hallmarks include accelerated cardiovascular disease and atherosc...
TRPM7 and magnesium orchestrate human CD4 T-cell activation and differentiation [0.03%]
TRPM7和镁调控人CD4T细胞的活化和分化
Anna Madlmayr,Kilian Hoelting,Birgit Karner-Hoeger et al.
Anna Madlmayr et al.
T-lymphocyte activation is a crucial process in the regulation of innate and adaptive immune responses. The ion channel-kinase TRPM7, transient receptor potential cation channel subfamily M, member 7, has previously been implicated in cellu...