Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle [0.03%]
Apicortin定义了疟原虫顶端锥体结构但对寄生虫生活周期是可有可无的蛋白质
Mohammad Zeeshan,Akancha Mishra,Sarah L Pashley et al.
Mohammad Zeeshan et al.
Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical polar rings, which are essential for parasite motility, host cell invasion, and re...
Deconstruction by C. thermocellum-from microbe mediated to dynamic redistribution of cellulosomes [0.03%]
热纤梭菌的解构作用：从微生物介导到纤维素酶复合体的动态重分布
John M Yarbrough,Neal N Hengge,Qi Xu et al.
John M Yarbrough et al.
Clostridium thermocellum is one of the most efficient microorganisms for the deconstruction of cellulosic biomass. To achieve this high level of cellulolytic activity, C. thermocellum uses large multienzyme complexes known as cellulosomes t...
Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia [0.03%]
选择性自噬通过降解Su(var)2-10/PIAS精炼果蝇星形胶质细胞中Stat92E活性
Virág Vincze,Zsombor Esküdt,Erzsébet Fehér-Juhász et al.
Virág Vincze et al.
Glial immunity plays a pivotal role in the maintenance of nervous system homeostasis and in responses to stress conditions, including neural injuries. The transcription factor Stat92E is activated independently of the canonical JAK/STAT pat...
Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side of endothelium [0.03%]
脑血管稳定性依赖于血管内皮细胞基底侧的PAK2-纤毛-PDGF-BB-HSPGs轴
Shubhangi Prabhudesai,Karthikeyan Thirugnanam,Xuehong Song et al.
Shubhangi Prabhudesai et al.
Endothelial cells (ECs) in the brain communicate with mural cells to facilitate vascular stability. Platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor receptor-β (PDGFR-β) signaling mechanism at EC-mural cell inter...
Intravital imaging of the formation and resolution of MHC class II-positive T-cell activation niches [0.03%]
生命成像描绘MHC II分子阳性T细胞活化微环境的形成与消失过程
David Oleksyn,Jim Miller
David Oleksyn
Intravital imaging has revealed many of the cellular interactions that regulate immune responses, but is limited by the number of cells that can be simultaneously identified and often restricted to analysis of a single time point. We have d...
The Janus framework of the integrated stress response: from homeostasis to maladaptation [0.03%]
整合应激反应的Janus框架：从稳态到适应不良
Dogus M Altintas,Marina Cerqua,Paolo M Comoglio et al.
Dogus M Altintas et al.
Every cell must adapt to environmental changes. When nutrients decrease, oxygen levels fall, or protein synthesis outpaces resources, cells activate stress pathways to restore balance. Among these, the integrated stress response (ISR) stand...
In vivo screen reveals specific roles of Hippo pathway components in development and regeneration [0.03%]
体内筛选揭示了Hippo信号通路组分在发育和再生过程中的特异性作用
Susanna E Riley,Michaela Noskova Fairley,Shijia Xia et al.
Susanna E Riley et al.
The Hippo signalling pathway is a major regulator of regeneration and development. However, the comparative importance and functional roles of individual Hippo pathway components in vivo are greatly unknown, particularly within the vertebra...
RB dependent transcriptional regulation at mitotic centromeres preserves genome stability [0.03%]
有丝分裂期着丝粒的RB依赖性转录调控可保持基因组稳定
Elizabeth A Crowley,Amity L Manning
Elizabeth A Crowley
Transcripts derived from centromere repeats play a critical role in the localization and activity of kinetochore components during mitosis such that disruption of RNA polymerase II-dependent transcription compromises the fidelity of chromos...
Multi-omics analysis reveals metabolic diversity underlying endothelial cell functions [0.03%]
多组学分析揭示内皮细胞功能背后的代谢多样性
Stephan Durot,Peter F Doubleday,Lydia Schulla et al.
Stephan Durot et al.
Endothelial cells (ECs) line the vascular system and are key players in vascular homeostasis, yet their metabolic diversity across tissues, vascular beds, and growth states remains poorly understood. This study examines metabolic difference...
Henu Kumar Verma,Carmela Morrone,Salome Rt Rehm et al.
Henu Kumar Verma et al.
Lung transplantation (LTx) offers life-saving therapy for end-stage lung disease, yet primary graft dysfunction (PGD) and bronchiolitis obliterans syndrome remain major complications, which limit long-term outcomes. The risk of PGD increase...