NCOA4 initiates ferritinophagy by avidly binding GATE16 using two short linear interaction motifs [0.03%]
NCOA4通过两个短的直线相互作用基元强烈结合GATE16启动铁蛋白自噬
April Lee,Joseph H Davis
April Lee
Cells carefully regulate cytosolic iron, which is a vital enzymatic cofactor, yet is toxic in excess. In mammalian cells, surplus iron is sequestered in ferritin cages that, in iron-limiting conditions, can be degraded through the selective...
TBK1 activity regulates the directionality of axonal transport of signalling endosomes [0.03%]
TBK1活性调节信号小胞体轴浆运输的方向性
David Villarroel-Campos,Jose Norberto S Vargas,Martin Wallace et al.
David Villarroel-Campos et al.
The polarised and complex morphology of neurons poses massive challenges for efficient cargo delivery between the axon and soma, a process termed axonal transport. We have previously shown that the retrograde axonal transport of pro-surviva...
Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation [0.03%]
FcγR介导的吞噬作用过程中Syk活化涉及Syk棕榈酰化和脱磺酰化
Maxime Jansen,Jean-Marc Strub,Laurent Chaloin et al.
Maxime Jansen et al.
The Syk tyrosine kinase acts downstream of several immune receptors such as the FcγR. Syk owns two SH2 domains that interact with biphosphorylated ITAMs of the FcγR upon phagocytosis. This results in the activation of Syk by autophosphory...
wgbstools: a computational suite for DNA methylation sequencing data analysis [0.03%]
WGBSTools：一种DNA甲基化测序数据分析计算工具包
Netanel Loyfer,Jonathan Rosenski,Tommy Kaplan
Netanel Loyfer
Next-generation methylation-aware sequencing of DNA sheds light on the fundamental role of methylation in cellular function in health and disease, increasing the number of covered CpG sites from hundreds of thousands in previous array-based...
Repeated proliferative events ameliorate age-associated accumulation of DNA damage in HSPCs [0.03%]
重复增殖事件可减轻与年龄相关的造血干细胞和祖细胞DNA损伤积累
Shubham Haribhau Mehatre,Harsh Agrawal,Irene Mariam Roy et al.
Shubham Haribhau Mehatre et al.
Upon aging, hematopoietic stem cells show accumulation of DNA damage that has been causally linked with their functional decline, with debatable role of proliferative events. In this study, we sought to enquire the effect of increased proli...
TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry [0.03%]
YAP在心肌细胞周期重新进入中的TEAD非依赖性作用机制
Bing Xie,Jeffrey Steimle,Vaibhav Deshmukh et al.
Bing Xie et al.
Adult mammalian hearts exhibit limited regenerative capacity because of the restricted renewal of cardiomyocytes. Recent studies reveal that mammalian hearts exhibit transient regenerative potential within a short time frame after birth, su...
Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung [0.03%]
诺特定时信号稳定肺多纤毛细胞中运动纤毛的长度
Neenu Joy,Aditya Deshpande,Sai Manoz Lingamallu et al.
Neenu Joy et al.
Airway multiciliated cells (MCs) maintain respiratory health by clearing mucus and trapped particles through coordinated ciliary beating. Although ciliary length progressively decreases along the proximal-distal (P-D) axis of the tracheobro...
Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation [0.03%]
USP15的靶向招募可增强CTLA4表面水平并限制其降解
Francesca Querques,Victoria Ciampani,Pei Yee Tey et al.
Francesca Querques et al.
Induced protein proximity offers powerful new routes to modulate protein fate. Whereas proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle, targeted protein stabilisation or enh...
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization [0.03%]
妊娠高血压综合征胎盘中聚集的淀粉样蛋白-β原纤维可抑制细胞滋养巨噬细胞化
Kaho Nishioka,Midori Ikezaki,Naoyuki Iwahashi et al.
Kaho Nishioka et al.
Cerebral deposition of fibrillar amyloid-β (Aβ) is a pathological hallmark of Alzheimer's disease. Although Aβ is present in human placentas and accumulates in preeclamptic placentas characterized by poor placentation, the production and...
Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons [0.03%]
视皮层轴突损伤后神经元微管动态及轴突生长受reticulon-1合成的调控
Alejandro Luarte,Javiera Gallardo,Daniela Corvalán et al.
Alejandro Luarte et al.
The regenerative potential of developing cortical axons depends on intrinsic mechanisms, such as axon-autonomous protein synthesis, that are still not fully understood. An emerging factor in this regenerative response is the bidirectional i...