Catalytic activity of KMT5B promotes ciliogenesis without affecting global chromatin accessibility [0.03%]
KMT5B的催化活性可促进纤毛生成而不会影响整体染色质可及性
Janet Tait,Carmen Marthen,Barbara Hoelscher et al.
Janet Tait et al.
Multiciliated cells (MCCs) are specialized cells found in the brain, reproductive and respiratory tracts of mammals, and the epidermis of tadpole-stage Xenopus embryos. KMT5B and KMT5C are histone methyltransferases that deposit the dimethy...
Correction: Divergent Plasmodium kinases drive MTOC, kinetochore, and axoneme organisation in male gametogenesis [0.03%]
纠正：分歧的Plasmodium激酶驱动了雄性配子发生中的MTOC、动盘体和轴突组织
Ryuji Yanase,Mohammad Zeeshan,David Jp Ferguson et al.
Ryuji Yanase et al.
This study reveals how Plasmodium kinases regulate MTOC, axoneme and kinetochore organisation in male gametogenesis, providing key insights into potential targets for malaria transmission control.
Published Erratum
Life science alliance. 2026 Mar 30;9(6):e202603692. DOI:10.26508/lsa.202603692 2026
Optimization of systemic AAV9 gene therapy in Niemann-Pick disease, type C1 mice [0.03%]
优化Niemann-Pick病C1型小鼠系统性AAV9基因治疗
Avani V Mylvara,Alana L Gibson,Tansy Gu et al.
Avani V Mylvara et al.
Niemann-Pick disease, type C1 (NPC1), is a rare, fatal neurodegenerative disorder caused by pathological variants in NPC1, which encodes a lysosomal cholesterol transporter. FDA-approved treatments are limited and do not target the underlyi...
TaoChongBao: a large-scale C. elegans missense variant database bridging worm and human genomes [0.03%]
TaoChongBao：连接秀丽隐杆线虫和人类基因组的大型错义变异数据库
Ming Li,Shimin Wang,Yongping Chai et al.
Ming Li et al.
We generated and sequenced 12,069 viable Caenorhabditis elegans strains produced by ethyl methanesulfonate mutagenesis, identifying 20,315,536 variants, including 541,102 unique missense mutations across 20,914 genes. Most strains exhibit r...
Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets [0.03%]
组蛋白甲基转移酶DOT1L影响不同树突状细胞亚群的发育
Rianne G Bouma,Willem-Jan de Leeuw,Aru Z Wang et al.
Rianne G Bouma et al.
Dendritic cells (DCs) orchestrate immune responses. Their development is controlled by transcription factors, but epigenetic mechanisms remain poorly understood. DOT1L emerges as a key epigenetic regulator in immune cells. Mapping DOT1L-med...
Enzymes of physiological amyloidogenesis control pathological amyloid toxicity [0.03%]
生理类淀粉原酶调控病理类淀粉毒性
Michael Bokros,Alex Grunfeld,Nathan C Balukoff et al.
Michael Bokros et al.
Physiological amyloidogenesis drives the formation of functional amyloids involved in various biochemical pathways. We recently showed that the RNA tailing and decay machinery controls the maturation of intracellular amyloid-like aggregates...
Huntingtin (HTT) interactome in regulation of DNA repair/remodeling and RNA processing pathways [0.03%]
亨廷顿蛋白（HTT）在DNA修复/重建和RNA处理通路中的互作组研究
Tamara Ratovitski,Chloe D Holland,Robert N O&#x;Meally et al.
Tamara Ratovitski et al.
Huntington's disease (HD), an uncurable neurodegenerative disorder, is caused by CAG repeat expansion in the HD gene encoding mutant huntingtin protein. DNA damage response is implicated in HD pathogenesis. We used multiple approaches to as...
TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells [0.03%]
TBXA2R激活ERM以促进三阴性乳腺癌细胞的运动、侵袭和转移殖民地形成
Kévin Leguay,Omaima Naffati,Camila Lie Kiyan et al.
Kévin Leguay et al.
Cell migration and invasion are critical for cancer cell metastasis, relying on the ability of cells to adapt their morphology. Proteins of the ezrin, radixin, and moesin (ERM) family are key regulators of cell morphogenesis and essential d...
Dectin-1 epigenetic reprogramming rescues senescent-like Treg function in allergic asthma [0.03%]
Dectin-1表观遗传重编程可修复过敏性哮喘中类衰老Treg功能
Xiangdong Sun,Jiaqi Duan,Le Liu et al.
Xiangdong Sun et al.
Allergic asthma is characterized by immune dysregulation, and deficiencies in regulatory T-cell (Treg) function are a hallmark of the disease. However, mechanisms of Treg impairment for their therapeutic correction remain poorly defined. Th...
Mutual feedback regulation between Poly(A)-specific ribonuclease (PARN) and cognate microRNAs [0.03%]
Poly(A)特异性的核糖核酸酶（PARN）与相应的微小RNA之间的互馈调节关系
Athanasios Kyritsis,Rafailia Aa Beta,Diana Scutelnic et al.
Athanasios Kyritsis et al.
The majority of pri-miRNAs acquire a 5' cap and 3' poly(A) tail. Mature miRNAs recruit deadenylases that shorten poly(Α) tails triggering target mRNA degradation. Poly(A)-specific ribonuclease (PARN) is a deadenylase that also mediates lat...