The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro [0.03%]
RBR E3泛素连接酶HOIL-1可以体外泛素化多种非蛋白底物
Xiangyi S Wang,Jenny Jiou,Anthony Cerra et al.
Xiangyi S Wang et al.
HOIL-1 is a RING-between-RING-family E3 ubiquitin ligase and a component of the linear ubiquitin chain assembly complex. Although most E3 ubiquitin ligases conjugate ubiquitin to protein lysine sidechains, HOIL-1 has also been reported to u...
Efficient identification of de novo mutations in family trios: a consensus-based informatic approach [0.03%]
家系三体中从头突变的高效鉴定:一种基于共识的信息学方法
Mariya Shadrina,Özem Kalay,Sinem Demirkaya-Budak et al.
Mariya Shadrina et al.
Accurate identification of de novo variants (DNVs) remains challenging despite advances in sequencing technologies, often requiring ad hoc filters and manual inspection. Here, we explored a purely informatic, consensus-based approach for id...
A novel human organoid model system reveals requirement of TCF4 for oligodendroglial differentiation [0.03%]
一个新的类人器官模型系统揭示了少突胶质细胞分化对TCF4的需求
Federica Furlanetto,Nicole Flegel,Marco Kremp et al.
Federica Furlanetto et al.
Heterozygous mutations of TCF4 in humans cause Pitt-Hopkins syndrome, a neurodevelopmental disease associated with intellectual disability and brain malformations. Although most studies focus on the role of TCF4 in neural stem cells and neu...
Rheological transition driven by matrix makes cancer spheroids resilient under confinement [0.03%]
基质驱动的流变转变使癌细胞团在受限条件下具有弹性
Tavishi Dutt,Jimpi Langthasa,Monica Umesh et al.
Tavishi Dutt et al.
Cancer metastasis through confining peritoneal microenvironments is mediated by spheroids: clusters of disseminated cells. Ovarian cancer spheroids are frequently cavitated; such blastuloid morphologies possess an outer ECM coat. We investi...
Molecular mechanism of bacteriophage contraction structure of an S-layer-penetrating bacteriophage [0.03%]
S层穿透噬菌体的噬菌体收缩结构的分子机制
Jason S Wilson,Louis-Charles Fortier,Robert P Fagan et al.
Jason S Wilson et al.
The molecular details of phage tail contraction and bacterial cell envelope penetration remain poorly understood and are completely unknown for phages infecting bacteria enveloped by proteinaceous S-layers. Here, we reveal the extended and ...
Antibodies targeting ADAM17 reverse neurite outgrowth inhibition by myelin-associated inhibitors [0.03%]
靶向ADAM17的抗体逆转髓鞘相关抑制因子对神经突起生长的抑制作用
Nayanendu Saha,Eric Chan,Rachelle P Mendoza et al.
Nayanendu Saha et al.
Upon spinal cord injury, axons attempting to regenerate need to overcome the repulsive actions of myelin-associated inhibitors, including the myelin-associated glycoprotein, Nogo-A, and the oligodendrocyte myelin glycoprotein. These inhibit...
Rapid ER remodeling induced by a peptide-lipid complex in dying tumor cells [0.03%]
死亡肿瘤细胞中由肽-脂质复合物快速诱导的内质网重塑
Samudra Sabari,Siddharth Chinchankar,Ines Ambite et al.
Samudra Sabari et al.
The membranous ER spans the entire cell, creating a network for the biosynthesis of proteins and lipids, cell-wide communication, and nuclear delivery of molecules, including therapeutic agents. Here, we identify a novel ER response trigger...
Cytokine storm and vascular leakage in severe dengue: insights from single-cell RNA profiling [0.03%]
重症登革热中的细胞因子风暴和血管渗漏：来自单细胞RNA谱分析的启示
Mohamad Al Kadi,Maika Yamashita,Masayuki Shimojima et al.
Mohamad Al Kadi et al.
Severe dengue is characterized by vascular leakage triggered by a hyperinflammatory response, though the underlying mechanisms remain unclear. Our previous mouse model study highlighted the importance of small intestine in severe disease an...
Divergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis [0.03%]
驱动疟原虫雄性配子体发生中的MTOC、动粒和鞭毛微管组织的分化激酶
Ryuji Yanase,Mohammad Zeeshan,David Jp Ferguson et al.
Ryuji Yanase et al.
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut are initiated by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by th...
TPX2 lactylation is required for the cell cycle regulation and hepatocellular carcinoma progression [0.03%]
TPX2的乳酸化作用对于细胞周期调控和肝细胞癌进程是必要的
Shengzhi Liu,Jin Cai,Xiaoyu Qian et al.
Shengzhi Liu et al.
Targeting protein for Xklp2 (TPX2) is critical for mitosis and spindle assembly because of its control of Aurora kinase A (AURKA). However, the regulation of TPX2 activity and its subsequent effects on mitosis and cancer progression remain ...